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Organocatalytic chiral polymeric nanoparticles for asymmetric aldol reaction

Chiral polymeric particles (CPPs) were studied extensively in recent years due to their importance in pharmaceutical applications. Here, nanosized CPPs were synthesized and applied as catalysts for direct asymmetric aldol reaction. The CPPs were prepared by miniemulsion or inverse miniemulsion based...

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Detalles Bibliográficos
Autores principales: Abuaf, Meir, Das, Subhomoy, Mastai, Yitzhak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817469/
https://www.ncbi.nlm.nih.gov/pubmed/36688059
http://dx.doi.org/10.1039/d2ra07244k
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author Abuaf, Meir
Das, Subhomoy
Mastai, Yitzhak
author_facet Abuaf, Meir
Das, Subhomoy
Mastai, Yitzhak
author_sort Abuaf, Meir
collection PubMed
description Chiral polymeric particles (CPPs) were studied extensively in recent years due to their importance in pharmaceutical applications. Here, nanosized CPPs were synthesized and applied as catalysts for direct asymmetric aldol reaction. The CPPs were prepared by miniemulsion or inverse miniemulsion based on various chiral amino acid derivatives and characterized by dynamic light scattering and scanning electron microscopy. The nanoparticles with spherical structure between 250 and 400 nm and high chiral surface area were used as catalysts in the aldol reaction at room temperature without additional solvent. l-tryptophan gave the highest enantiomeric excess, >86% with similar catalytic performance four times.
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spelling pubmed-98174692023-01-20 Organocatalytic chiral polymeric nanoparticles for asymmetric aldol reaction Abuaf, Meir Das, Subhomoy Mastai, Yitzhak RSC Adv Chemistry Chiral polymeric particles (CPPs) were studied extensively in recent years due to their importance in pharmaceutical applications. Here, nanosized CPPs were synthesized and applied as catalysts for direct asymmetric aldol reaction. The CPPs were prepared by miniemulsion or inverse miniemulsion based on various chiral amino acid derivatives and characterized by dynamic light scattering and scanning electron microscopy. The nanoparticles with spherical structure between 250 and 400 nm and high chiral surface area were used as catalysts in the aldol reaction at room temperature without additional solvent. l-tryptophan gave the highest enantiomeric excess, >86% with similar catalytic performance four times. The Royal Society of Chemistry 2023-01-06 /pmc/articles/PMC9817469/ /pubmed/36688059 http://dx.doi.org/10.1039/d2ra07244k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Abuaf, Meir
Das, Subhomoy
Mastai, Yitzhak
Organocatalytic chiral polymeric nanoparticles for asymmetric aldol reaction
title Organocatalytic chiral polymeric nanoparticles for asymmetric aldol reaction
title_full Organocatalytic chiral polymeric nanoparticles for asymmetric aldol reaction
title_fullStr Organocatalytic chiral polymeric nanoparticles for asymmetric aldol reaction
title_full_unstemmed Organocatalytic chiral polymeric nanoparticles for asymmetric aldol reaction
title_short Organocatalytic chiral polymeric nanoparticles for asymmetric aldol reaction
title_sort organocatalytic chiral polymeric nanoparticles for asymmetric aldol reaction
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817469/
https://www.ncbi.nlm.nih.gov/pubmed/36688059
http://dx.doi.org/10.1039/d2ra07244k
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