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An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo‐controlled, double blind intervention study

BACKGROUND AND AIMS: Female pattern hair loss affects females of all ages with a trend to increase after menopause. This disorder may have significant psychological impact and lead to anxiety and depression. OBJECTIVE: In a single center, double blind, randomized, placebo‐controlled study, the effec...

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Autores principales: Cai, Carr, Zeng, Bill, Lin, Lydia, Zheng, Miranda, Burki, Carolina, Grether‐Beck, Susanne, Krutmann, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817492/
https://www.ncbi.nlm.nih.gov/pubmed/36620515
http://dx.doi.org/10.1002/hsr2.1045
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author Cai, Carr
Zeng, Bill
Lin, Lydia
Zheng, Miranda
Burki, Carolina
Grether‐Beck, Susanne
Krutmann, Jean
author_facet Cai, Carr
Zeng, Bill
Lin, Lydia
Zheng, Miranda
Burki, Carolina
Grether‐Beck, Susanne
Krutmann, Jean
author_sort Cai, Carr
collection PubMed
description BACKGROUND AND AIMS: Female pattern hair loss affects females of all ages with a trend to increase after menopause. This disorder may have significant psychological impact and lead to anxiety and depression. OBJECTIVE: In a single center, double blind, randomized, placebo‐controlled study, the effects of oral Pycnogenol® intake (3 × 50 mg/day for a total of 6 months) on hair density, scalp microcirculation, and a variety of skin physiological parameters was studied in Han Chinese menopausal women (N = 76) in Shanghai, China. METHODS: Measurements were taken at the beginning and after 2 and 6 months, respectively. Hair density was determined by digital photographs and further evaluated by Trichoscan software. Transepidermal water loss was measured by a humidity sensor in a closed chamber on the skin surface. Changes in microcirculation were detected as resting flux on the scalp by reflection photoplethysmography. RESULTS: Pycnogenol® intake significantly increased hair density by 30% and 23% after 2 and 6 months of treatment, respectively, as detected by Trichoscan® evaluation of digital photographs. Interestingly, photoplethysmography revealed that this beneficial effect was associated with a decrease in resting flux of the scalp skin, which might indicate an improvement of microcirculation. None of these effects were observed in the placebo taking group. In addition, a significant transient decrease of transepidermal water loss was observed in scalp skin under Pycnogenol,® but not placebo treatment. CONCLUSION: Oral intake of Pycnogenol® might have the potential to reduce hair loss in postmenopausal women.
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spelling pubmed-98174922023-01-06 An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo‐controlled, double blind intervention study Cai, Carr Zeng, Bill Lin, Lydia Zheng, Miranda Burki, Carolina Grether‐Beck, Susanne Krutmann, Jean Health Sci Rep Original Research BACKGROUND AND AIMS: Female pattern hair loss affects females of all ages with a trend to increase after menopause. This disorder may have significant psychological impact and lead to anxiety and depression. OBJECTIVE: In a single center, double blind, randomized, placebo‐controlled study, the effects of oral Pycnogenol® intake (3 × 50 mg/day for a total of 6 months) on hair density, scalp microcirculation, and a variety of skin physiological parameters was studied in Han Chinese menopausal women (N = 76) in Shanghai, China. METHODS: Measurements were taken at the beginning and after 2 and 6 months, respectively. Hair density was determined by digital photographs and further evaluated by Trichoscan software. Transepidermal water loss was measured by a humidity sensor in a closed chamber on the skin surface. Changes in microcirculation were detected as resting flux on the scalp by reflection photoplethysmography. RESULTS: Pycnogenol® intake significantly increased hair density by 30% and 23% after 2 and 6 months of treatment, respectively, as detected by Trichoscan® evaluation of digital photographs. Interestingly, photoplethysmography revealed that this beneficial effect was associated with a decrease in resting flux of the scalp skin, which might indicate an improvement of microcirculation. None of these effects were observed in the placebo taking group. In addition, a significant transient decrease of transepidermal water loss was observed in scalp skin under Pycnogenol,® but not placebo treatment. CONCLUSION: Oral intake of Pycnogenol® might have the potential to reduce hair loss in postmenopausal women. John Wiley and Sons Inc. 2023-01-06 /pmc/articles/PMC9817492/ /pubmed/36620515 http://dx.doi.org/10.1002/hsr2.1045 Text en © 2023 The Authors. Health Science Reports published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Cai, Carr
Zeng, Bill
Lin, Lydia
Zheng, Miranda
Burki, Carolina
Grether‐Beck, Susanne
Krutmann, Jean
An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo‐controlled, double blind intervention study
title An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo‐controlled, double blind intervention study
title_full An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo‐controlled, double blind intervention study
title_fullStr An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo‐controlled, double blind intervention study
title_full_unstemmed An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo‐controlled, double blind intervention study
title_short An oral French maritime pine bark extract improves hair density in menopausal women: A randomized, placebo‐controlled, double blind intervention study
title_sort oral french maritime pine bark extract improves hair density in menopausal women: a randomized, placebo‐controlled, double blind intervention study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817492/
https://www.ncbi.nlm.nih.gov/pubmed/36620515
http://dx.doi.org/10.1002/hsr2.1045
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