Cargando…

Cancer Cells Upregulate Tau to Gain Resistance to DNA Damaging Agents

SIMPLE SUMMARY: The role of Tau in genome protection and/or repair in neurons suggests that Tau expression in cancer cells could be involved in resistance to conventional anti-cancer treatments, in particular those inducing DNA damage. Knockdown of Tau in breast cancer cell lines improved the cellul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rico, Thomas, Denechaud, Marine, Caillierez, Raphaelle, Comptdaer, Thomas, Adriaenssens, Eric, Buée, Luc, Lefebvre, Bruno
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817522/ https://www.ncbi.nlm.nih.gov/pubmed/36612113 http://dx.doi.org/10.3390/cancers15010116

Ejemplares similares

Tau Stabilizes Chromatin Compaction
por: Rico, Thomas, et al.
Publicado: (2021)

A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions
por: Violet, Marie, et al.
Publicado: (2014)

Different tau species lead to heterogeneous tau pathology propagation and misfolding
por: Dujardin, Simon, et al.
Publicado: (2018)

Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody
por: Albert, Marie, et al.
Publicado: (2019)

Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment
por: Danis, Clément, et al.
Publicado: (2022)

Ectosomes: A New Mechanism for Non-Exosomal Secretion of Tau Protein
por: Dujardin, Simon, et al.
Publicado: (2014)

Extracellular vesicles: Major actors of heterogeneity in tau spreading among human tauopathies
por: Leroux, Elodie, et al.
Publicado: (2022)

Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies
por: Dujardin, Simon, et al.
Publicado: (2014)

Chronic Sodium Selenate Treatment Restores Deficits in Cognition and Synaptic Plasticity in a Murine Model of Tauopathy
por: Ahmed, Tariq, et al.
Publicado: (2020)

Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy
por: Zheng, Jin, et al.
Publicado: (2020)

MicroRNAs and the Regulation of Tau Metabolism
por: Hébert, Sébastien S., et al.
Publicado: (2012)

The Chemokine MIP-1α/CCL3 impairs mouse hippocampal synaptic transmission, plasticity and memory
por: Marciniak, Elodie, et al.
Publicado: (2015)

EuroTau: towing scientists to tau without tautology
por: Mudher, Amrit, et al.
Publicado: (2017)

Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?
por: Laurent, Cyril, et al.
Publicado: (2018)

Genome-wide identification of genic and intergenic neuronal DNA regions bound by Tau protein under physiological and stress conditions
por: Benhelli-Mokrani, Houda, et al.
Publicado: (2018)

Tau and DNA Damage in Neurodegeneration
por: Colnaghi, Luca, et al.
Publicado: (2020)

Tau mRNA Metabolism in Neurodegenerative Diseases: A Tangle Journey
por: da Costa, Paulo J., et al.
Publicado: (2022)

AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo
por: Domise, Manon, et al.
Publicado: (2016)

Tau- but not Aß -pathology enhances NMDAR-dependent depotentiation in AD-mouse models
por: Faldini, Enrico, et al.
Publicado: (2019)

Regulation of human MAPT gene expression
por: Caillet-Boudin, Marie-Laure, et al.
Publicado: (2015)

Detrimental Effects of Diet-Induced Obesity on τ Pathology Are Independent of Insulin Resistance in τ Transgenic Mice
por: Leboucher, Antoine, et al.
Publicado: (2013)

Two-Dimensional Electrophoresis of Tau Mutants Reveals Specific Phosphorylation Pattern Likely Linked to Early Tau Conformational Changes
por: Bretteville, Alexis, et al.
Publicado: (2009)

Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies
por: Tardivel, Meryem, et al.
Publicado: (2016)

Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin
por: Mansuroglu, Zeyni, et al.
Publicado: (2016)

From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy
por: Colin, Morvane, et al.
Publicado: (2019)

Combating resistance to DNA damaging agents
por: Choi, Jung-Suk, et al.
Publicado: (2018)

DNA damaging agents in ovarian cancer
por: Barretina-Ginesta, Maria-Pilar
Publicado: (2020)

Reduced Tau protein expression is associated with frontotemporal degeneration with progranulin mutation
por: Papegaey, Anthony, et al.
Publicado: (2016)

Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms
por: Derisbourg, Maxime, et al.
Publicado: (2015)

A Novel Tau Antibody Detecting the First Amino-Terminal Insert Reveals Conformational Differences Among Tau Isoforms
por: Verelst, Joke, et al.
Publicado: (2020)

Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate
por: Lam, Suzanne, et al.
Publicado: (2021)

Tau Isoforms: Gaining Insight into MAPT Alternative Splicing
por: Corsi, Andrea, et al.
Publicado: (2022)

A walk through tau therapeutic strategies
por: Jadhav, Santosh, et al.
Publicado: (2019)

Immunodetection of Tau microtubule-associated protein in human sperm and testis
por: Sigala, Julien, et al.
Publicado: (2014)

Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology
por: Dourlen, P, et al.
Publicado: (2017)

Encephalopathy induced by Alzheimer brain inoculation in a non-human primate
por: Gary, Charlotte, et al.
Publicado: (2019)

Neurogenesis and cell cycle-reactivated neuronal death during pathogenic tau aggregation
por: Schindowski, K, et al.
Publicado: (2008)

The organization of microtubules and Tau in oligodendrocytes: Tau pathology in damaged oligodendrocytes
por: Torii, Tomohiro, et al.
Publicado: (2022)

Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology
por: Sierksma, Annerieke, et al.
Publicado: (2018)

Upregulated DNA Damage-Linked Biomarkers in Parkinson's Disease Model Mice
por: Zeng, Fei, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_itvlk5641lgqgv44qirpvdonh3