Research Progress and Direction of Novel Organelle—Migrasomes

SIMPLE SUMMARY: Migrasomes are a new type of organelle. Cells migrate and produce retraction fibers (RFs) with migrasomes on their backsides. When the RFs break, the migrasomes detach from the cell and the contents are taken up by surrounding cells. Migrasomes can integrate and transmit information, thereby regulating the physiological activities of the body. It has been confirmed that migrasomes are related to the occurrence and development of some diseases. In some cancers, the high expression of migrasomes is closely related to the occurrence and development of tumors. This review introduces the research progress of migrasomes and new ideas for research directions. ABSTRACT: Migrasomes are organelles that are similar in structure to pomegranates, up to 3 μm in diameter, and contain small vesicles with a diameter of 50–100 nm. These membranous organelles grow at the intersections or tips of retracting fibers at the back of migrating cells. The process by which cells release migrasomes and their contents outside the cell is called migracytosis. The signal molecules are packaged in the migrasomes and released to the designated location by migrasomes to activate the surrounding cells. Finally, the migrasomes complete the entire process of information transmission. In this sense, migrasomes integrate time, space, and specific chemical information, which are essential for regulating physiological processes such as embryonic development and tumor invasion and migration. In this review, the current research progress of migrasomes, including the discovery of migrasomes and migracytosis, the structure of migrasomes, and the distribution and functions of migrasomes is discussed. The migratory marker protein TSPAN4 is highly expressed in various cancers and is associated with cancer invasion and migration. Therefore, there is still much research space for the pathogenesis of migratory bodies and cancer. This review also makes bold predictions and prospects for the research directions of the combination of migrasomes and clinical applications.