Effects of Kadsura coccinea L. Fruit Extract on Growth Performance, Meat Quality, Immunity, Antioxidant, Intestinal Morphology and Flora of White-Feathered Broilers

SIMPLE SUMMARY: Kadsura coccinea was planted in large quantities in south China in recent years, and its functions and effects need to be further studied and discovered. We had previously found that Kadsura coccinea fruit extract has anti-diarrhea effects on mice, so we want to explore its influence on broiler breeding. The result showed that added 200 mg/kg Kadsura coccinea fruit extract to basic feed can replace traditional antibiotics as a growth promoter. It can improve the growth, slaughter performance, and antioxidant and regulate intestinal microorganisms of broilers, which indicated that the Kadsura coccinea fruit extract is feasible as a feed additive. ABSTRACT: This study aimed to determine whether adding Kadsura coccinea fruit extract to the diet of broilers could replace antibiotics. For this study, 300 one-day-old AA white feathered broilers were divided into five groups (no sex separated), with six repetitions per group (n = 10), as follows: blank control group (basal feed, CK group), positive drug (basal feed + 300 mg/kg aureomycin, PD group), and Kadsura coccinea low-dose, medium-dose, and high-dose groups (basal feed + 100 mg/kg, 200 mg/kg, and 300 mg/kg of Kadsura coccinea fruit extract, LD group, MD group and HD group). The experiment period was divided into early (1–21 days) and late (22–42 days) stage. We found that supplementation with Kadsura coccinea fruit extract in the diet significantly improved the growth performance of broilers (p < 0.05), reduced the feed to meat ratio (p < 0.05), reduced the fat percentage (p < 0.05), while had no significant effect on meat quality (p > 0.05) and Kadsura coccinea fruit extract could promote the development of immune organs to different extents, enhance antioxidant capacity, the contents of SOD and GSH-Px in serum were significantly increased (p < 0.05), improve the ratio of villus height to crypt depth. Finally, Kadsura coccinea fruit extract increased the relative abundance of probiotics and beneficial bacteria (Bacteroidales, NK4A214, Subdoligranulum and Eubacterium hallii) (p < 0.05) and reduced the relative abundance of harmful bacteria (Erysipelatoclostridium) (p < 0.05) in the gut of broilers. Compared with positive drug group, most of the indexes in the medium-dose group were better or had similar effects. We believe that Kadsura coccinea fruit extract can be used as a potential natural antibiotic substitute in livestock and poultry breeding programs.