Cargando…

Low CD8 T Cell Counts Predict Benefit from Hypoxia-Modifying Therapy in Muscle-Invasive Bladder Cancer

SIMPLE SUMMARY: Precision medicine is needed for muscle-invasive bladder cancer to improve survival rates due to high rates of tumour recurrence and poor patient outcomes. Hypoxia and an immunosuppressive tumour microenvironment are both independent poor prognostic factors that are targetable by hyp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Smith, Vicky, Mukherjee, Debayan, Tsakiroglou, Anna Maria, Baker, Alexander, Mistry, Hitesh, Choudhury, Ananya, Hoskin, Peter, Illidge, Timothy, West, Catharine M. L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817934/ https://www.ncbi.nlm.nih.gov/pubmed/36612036 http://dx.doi.org/10.3390/cancers15010041

Ejemplares similares

The effect of hypoxia on PD-L1 expression in bladder cancer
por: Smith, Vicky, et al.
Publicado: (2021)

Hypoxia Is Associated with Increased Immune Infiltrates and Both Anti-Tumour and Immune Suppressive Signalling in Muscle-Invasive Bladder Cancer
por: Smith, Vicky, et al.
Publicado: (2023)

A miRNA signature predicts benefit from addition of hypoxia-modifying therapy to radiation treatment in invasive bladder cancer
por: Khan, Mairah T., et al.
Publicado: (2021)

Necrosis predicts benefit from hypoxia-modifying therapy in patients with high risk bladder cancer enrolled in a phase III randomised trial()
por: Eustace, Amanda, et al.
Publicado: (2013)

Expression of miR-210 in relation to other measures of hypoxia and prediction of benefit from hypoxia modification in patients with bladder cancer
por: Irlam-Jones, J J, et al.
Publicado: (2016)

Expression of hypoxia-inducible factor-1α predicts benefit from hypoxia modification in invasive bladder cancer
por: Hunter, B A, et al.
Publicado: (2014)

Pretreatment Lymphocyte Count Predicts Benefit From Concurrent Chemotherapy With Radiotherapy in Oropharyngeal Cancer
por: Price, James M., et al.
Publicado: (2022)

Development and validation of a hypoxia-associated signature for lung adenocarcinoma
por: Lane, Brian, et al.
Publicado: (2022)

Prediction of prostate tumour hypoxia using pre-treatment MRI-derived radiomics: preliminary findings
por: Zhong, Jim, et al.
Publicado: (2023)

Validation of a hypoxia related gene signature in multiple soft tissue sarcoma cohorts
por: Yang, Lingjian, et al.
Publicado: (2017)

Correction: Validation of a hypoxia related gene signature in multiple soft tissue sarcoma cohorts
por: Yang, Lingjian, et al.
Publicado: (2019)

Technical development and validation of a clinically applicable microenvironment classifier as a biomarker of tumour hypoxia for soft tissue sarcoma
por: Forker, Laura J., et al.
Publicado: (2023)

Hypofractionated radiotherapy in locally advanced bladder cancer: an individual patient data meta-analysis of the BC2001 and BCON trials
por: Choudhury, Ananya, et al.
Publicado: (2021)

Imaging hypoxia in endometrial cancer: How and why should it be done?
por: deSouza, Nandita M., et al.
Publicado: (2022)

Bladder Preservation for Muscle Invasive Bladder Cancer
por: Mirza, Arafat, et al.
Publicado: (2016)

The CD40 agonist HERA-CD40L results in enhanced activation of antigen presenting cells, promoting an anti-tumor effect alone and in combination with radiotherapy
por: Frankish, Jamie, et al.
Publicado: (2023)

The predictive and prognostic value of tumour necrosis in muscle invasive bladder cancer patients receiving radiotherapy with or without chemotherapy in the BC2001 trial (CRUK/01/004)
por: Choudhury, Ananya, et al.
Publicado: (2017)

GLUT1 and CAIX as intrinsic markers of hypoxia in bladder cancer: relationship with vascularity and proliferation as predictors of outcome of ARCON
por: Hoskin, P J, et al.
Publicado: (2003)

Clinical trials targeting hypoxia
por: Tharmalingham, Hannah, et al.
Publicado: (2019)

Metastatic Bladder Cancer: A Review of Current Management
por: Fletcher, Andrew, et al.
Publicado: (2011)

Exploring trends in advanced bladder cancer using the NCDB: turning data into information and information into insight
por: Thiruthaneeswaran, Niluja, et al.
Publicado: (2018)

Akt inhibition improves long‐term tumour control following radiotherapy by altering the microenvironment
por: Searle, Emma J, et al.
Publicado: (2017)

The hypoxia marker CAIX is prognostic in the UK phase III VorteX-Biobank cohort: an important resource for translational research in soft tissue sarcoma
por: Forker, Laura, et al.
Publicado: (2018)

A practical approach to bladder preservation with hypofractionated radiotherapy for localised muscle-invasive bladder cancer
por: Portner, R., et al.
Publicado: (2021)

Immune infiltrate diversity confers a good prognosis in follicular lymphoma
por: Tsakiroglou, Anna-Maria, et al.
Publicado: (2021)

MRE11 as a Predictive Biomarker of Outcome After Radiation Therapy in Bladder Cancer
por: Walker, Alexandra K., et al.
Publicado: (2019)

Spatial proximity between T and PD-L1 expressing cells as a prognostic biomarker for oropharyngeal squamous cell carcinoma
por: Tsakiroglou, Anna Maria, et al.
Publicado: (2019)

Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer
por: Yang, Lingjian, et al.
Publicado: (2018)

Effect of Environmental Exposure on the Pore Structure and Transport Properties of Carbon Nanotube-Modified Mortars
por: Alafogianni, Panagiota, et al.
Publicado: (2020)

Two years CD4 count follow-up of rural patients on antiretroviral therapy: A study in Government Hospital
por: Dravid, Mrudula N, et al.
Publicado: (2011)

Sarcopenia in cancer: Risking more than muscle loss
por: Anjanappa, Milan, et al.
Publicado: (2020)

Long terms trends in CD4(+) cell counts, CD8(+) cell counts, and the CD4(+) : CD8(+) ratio
por: Hughes, Rachael A., et al.
Publicado: (2018)

A Modified Method of Reticulocyte Count
por: Bose, A. N., et al.
Publicado: (1942)

Technical Basics and Clinical Benefits of Photon-Counting CT
por: Flohr, Thomas, et al.
Publicado: (2023)

The impact of bladder preparation protocols on post treatment toxicity in radiotherapy for localised prostate cancer patients
por: Tsang, Yat Man, et al.
Publicado: (2017)

Analysis of variants in DNA damage signalling genes in bladder cancer
por: Choudhury, Ananya, et al.
Publicado: (2008)

Radical External-Beam Radiotherapy in Combination With Intracavitary Brachytherapy for Localized Carcinoma of the Cervix in Sri Lanka: Is Treatment Delayed Treatment Denied?
por: Joseph, Nuradh, et al.
Publicado: (2020)

Defining Oligometastatic Bladder Cancer: A Systematic Review
por: Bamias, Aristotelis, et al.
Publicado: (2023)

Peripheral blood CD4+ cell counts but not CD3+ and CD8+ cell counts are reduced in SARS-CoV-2 infection
por: Huang, Zhi-Xin, et al.
Publicado: (2020)

Reirradiation Options for Previously Irradiated Prostate cancer (RO-PIP): Feasibility study investigating toxicity outcomes following reirradiation with stereotactic body radiotherapy (SBRT) versus high-dose-rate brachytherapy (HDR-BT)
por: Zhong, Jim, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1h36f87hac1f52qnojll25hg2o