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Evolutionary Analysis of TCGA Data Using Over- and Under- Mutated Genes Identify Key Molecular Pathways and Cellular Functions in Lung Cancer Subtypes

SIMPLE SUMMARY: Evolution drives the initiation and progression of cancer. This is apparent in the concept of “driver mutations” that initiate cancer and observed in cells of the lineage. Less appreciated is natural selection’s role in conserving genes that are necessary for optimal cancer cell fitn...

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Detalles Bibliográficos
Autores principales:	Freischel, Audrey R., Teer, Jamie K., Luddy, Kimberly, Cunningham, Jessica, Artzy-Randrup, Yael, Epstein, Tamir, Tsai, Kenneth Y., Berglund, Anders, Cleveland, John L., Gillies, Robert J., Brown, Joel S., Gatenby, Robert A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9817988/ https://www.ncbi.nlm.nih.gov/pubmed/36612014 http://dx.doi.org/10.3390/cancers15010018

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