Targeted Therapy with PI3K, PARP, and WEE1 Inhibitors and Radiotherapy in HPV Positive and Negative Tonsillar Squamous Cell Carcinoma Cell Lines Reveals Synergy while Effects with APR-246 Are Limited

SIMPLE SUMMARY: Human papillomavirus positive tonsillar and base of tongue cancers are rising in incidence but chemoradiotherapy has not improved survival, so novel treatments are needed. Therefore, targeted therapy with phosphoinositide 3-kinase, poly-ADP-ribose-polymerase, and WEE1 inhibitors was...

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Detalles Bibliográficos
Autores principales: Byskata, Karin, Lukoseviciute, Monika, Tuti, Filippo, Zupancic, Mark, Kostopoulou, Ourania N., Holzhauser, Stefan, Dalianis, Tina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818008/
https://www.ncbi.nlm.nih.gov/pubmed/36612094
http://dx.doi.org/10.3390/cancers15010093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818008/
https://www.ncbi.nlm.nih.gov/pubmed/36612094
http://dx.doi.org/10.3390/cancers15010093

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