One Health: Animal Models of Heritable Human Bleeding Diseases

SIMPLE SUMMARY: Animal models of human and animal diseases have been studied for decades in both experimental and clinical research with the findings applied to their management and therapy. Today, molecular and genomic research has led to the gene editing and gene therapies of an increasing number of these disorders. This review summarizes current knowledge about the molecular genetics and therapeutic approaches applied to the heritable human and animal bleeding diseases. ABSTRACT: Animal models of human and animal diseases have long been used as the lynchpin of experimental and clinical research. With the discovery and implementation of novel molecular and nano-technologies, cellular research now has advanced to assessing signal transduction pathways, gene editing, and gene therapies. The contribution of heritable animal models to human and animal health as related to hemostasis is reviewed and updated with the advent of gene editing, recombinant and gene therapies.