Delivery of CRISPR/Cas9 Plasmid DNA by Hyperbranched Polymeric Nanoparticles Enables Efficient Gene Editing

Gene editing nucleases such as CRISPR/Cas9 have enabled efficient and precise gene editing in vitro and hold promise of eventually achieving in vivo gene editing based therapy. However, a major challenge for their use is the lack of a safe and effective virus-free system to deliver gene editing nucl...

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Detalles Bibliográficos
Autores principales: Xiu, Kemao, Saunders, Laura, Wen, Luan, Ruan, Jinxue, Dong, Ruonan, Song, Jun, Yang, Dongshan, Zhang, Jifeng, Xu, Jie, Chen, Y. Eugene, Ma, Peter X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818138/
https://www.ncbi.nlm.nih.gov/pubmed/36611948
http://dx.doi.org/10.3390/cells12010156

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