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Impact of Mitochondrial A3243G Heteroplasmy on Mitochondrial Bioenergetics and Dynamics of Directly Reprogrammed MELAS Neurons

The MELAS syndrome primarily affecting the CNS is mainly caused by the m.A3243G mutation. The heteroplasmy in different tissues affects the phenotypic spectrum, yet the impact of various levels of m.A3243G heteroplasmy on CNS remains elusive due to the lack of a proper neuronal model harboring m.A32...

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Detalles Bibliográficos
Autores principales: Lin, Dar-Shong, Huang, Yu-Wen, Ho, Che-Sheng, Huang, Tung-Sun, Lee, Tsung-Han, Wu, Tsu-Yen, Huang, Zon-Darr, Wang, Tuan-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818214/
https://www.ncbi.nlm.nih.gov/pubmed/36611807
http://dx.doi.org/10.3390/cells12010015

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