Cargando…

Low Expression of Phosphodiesterase 2 (PDE2A) Promotes the Progression by Regulating Mitochondrial Morphology and ATP Content and Predicts Poor Prognosis in Hepatocellular Carcinoma

Phosphodiesterase 2 (PDE2A) modulates the levels of cAMP/cGMP and was recently found to be involved in mitochondria function regulation, closely related to multiple types of tumor progression. This study aimed to estimate the prognostic significance and biological effects of PDE2A on hepatocellular...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Lin, Zhou, Jinchi, Zhao, Zifeng, Zhu, Yuhan, Xing, Jinliang, An, Jiaze, Guo, Xu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818237/ https://www.ncbi.nlm.nih.gov/pubmed/36611861 http://dx.doi.org/10.3390/cells12010068

Ejemplares similares

Phosphodiesterase (PDE)-4 Inhibitors and COPD Correlation with Cancer
por: Organtzis, John, et al.
Publicado: (2014)

Expression of Phosphodiesterase (PDE) Isoenzymes in the Human Male and Female Urethra
por: Rahardjo, Harrina E, et al.
Publicado: (2021)

Upregulation of histamine receptor H1 promotes tumor progression and contributes to poor prognosis in hepatocellular carcinoma
por: Zhao, Jing, et al.
Publicado: (2019)

Calcium/Calpain mediated regulation of cyclic nucleotide phosphodiesterases, PDE3A and PDE5, in human platelets
por: Rybalkina, Irina G, et al.
Publicado: (2011)

Mitochondrial Complex I Core Protein Regulates cAMP Signaling via Phosphodiesterase Pde2 and NAD Homeostasis in Candida albicans
por: She, Xiaodong, et al.
Publicado: (2020)

Identification of cytosolic phosphodiesterases in the erythrocyte: A possible role for PDE5
por: Adderley, Shaquria P., et al.
Publicado: (2011)

Expression of phosphodiesterase 6 (PDE6) in human breast cancer cells
por: Dong, Hongli, et al.
Publicado: (2013)

Inhaled Phosphodiesterase 4 (PDE4) Inhibitors for Inflammatory Respiratory Diseases
por: Phillips, Jonathan E.
Publicado: (2020)

Treatment of Experimental Autoimmune Encephalomyelitis with an Inhibitor of Phosphodiesterase-8 (PDE8)
por: Basole, Chaitali P., et al.
Publicado: (2022)

Determination of Phosphodiesterase Type-5 Inhibitors (PDE-5) in Dietary Supplements
por: Gheorghiu, Oana Ramona Cătălina, et al.
Publicado: (2023)

Role of Phosphodiesterase 7 (PDE7) in T Cell Activity. Effects of Selective PDE7 Inhibitors and Dual PDE4/7 Inhibitors on T Cell Functions
por: Szczypka, Marianna
Publicado: (2020)

PDE4a predicts poor prognosis and promotes metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma
por: Peng, Yanghong, et al.
Publicado: (2018)

Reversal of neurobehavioral social deficits in dystrophic mice using inhibitors of phosphodiesterases PDE5A and PDE9A
por: Alexander, M S, et al.
Publicado: (2016)

The Delta Subunit of Rod-Specific Photoreceptor cGMP Phosphodiesterase (PDE6D) Contributes to Hepatocellular Carcinoma Progression
por: Dietrich, Peter, et al.
Publicado: (2019)

Acute effects of phosphodiesterase 5 (PDE5) inhibition, ANP and NO on epididymal contractility are preserved despite chronic PDE5 exposure
por: Mietens, Andrea, et al.
Publicado: (2011)

Phosphodiesterase 9 (PDE9) regulates bovine tracheal smooth muscle relaxation
por: TAJIMA, Tsuyoshi, et al.
Publicado: (2018)

Meta-Analysis of the Association Between Phosphodiesterase Inhibitors (PDE5Is) and Risk of Melanoma
por: Loeb, Stacy, et al.
Publicado: (2017)

Inhibition of calcium-calmodulin-dependent phosphodiesterase (PDE1) suppresses inflammatory responses
por: O'Brien, Jennifer J., et al.
Publicado: (2019)

Type-4 Phosphodiesterase (PDE4) Blockade Reduces NETosis in Cystic Fibrosis
por: Totani, Licia, et al.
Publicado: (2021)

Impact of phosphodiesterases PDE3 and PDE4 on 5-hydroxytryptamine receptor4-mediated increase of cAMP in human atrial fibrillation
por: Dolce, Bernardo, et al.
Publicado: (2020)

Radiosynthesis and Preclinical Evaluation of an (18)F-Labeled Triazolopyridopyrazine-Based Inhibitor for Neuroimaging of the Phosphodiesterase 2A (PDE2A)
por: Wenzel, Barbara, et al.
Publicado: (2022)

Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases
por: Omar, Faisa, et al.
Publicado: (2019)

Phosphodiesterase 1b (PDE1B) Regulates Spatial and Contextual Memory in Hippocampus
por: McQuown, Susan, et al.
Publicado: (2019)

Type 5 phosphodiesterase (PDE5) and the vascular tree: From embryogenesis to aging and disease
por: Cesarini, Valeriana, et al.
Publicado: (2020)

The High-Affinity Phosphodiesterase BcPde2 Has Impact on Growth, Differentiation and Virulence of the Phytopathogenic Ascomycete Botrytis cinerea
por: Harren, Karin, et al.
Publicado: (2013)

PDE2 Inhibits PKA-Mediated Phosphorylation of TFAM to Promote Mitochondrial Ca(2+)-Induced Colorectal Cancer Growth
por: Zhao, Yilin, et al.
Publicado: (2021)

High leukocyte mtDNA content contributes to poor prognosis through ROS-mediated immunosuppression in hepatocellular carcinoma patients
por: He, Xianli, et al.
Publicado: (2016)

Sex-differential genetic effect of phosphodiesterase 4D (PDE4D) on carotid atherosclerosis
por: Liao, Yi-Chu, et al.
Publicado: (2010)

Asymmetric properties of rod cGMP Phosphodiesterase 6 (PDE6): structural and functional analysis
por: Qureshi, Bilal M, et al.
Publicado: (2015)

Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue
por: Ahmad, Faiyaz, et al.
Publicado: (2016)

Emerging Potential of the Phosphodiesterase (PDE) Inhibitor Ibudilast for Neurodegenerative Diseases: An Update on Preclinical and Clinical Evidence
por: Angelopoulou, Efthalia, et al.
Publicado: (2022)

The evolution and structure of snake venom phosphodiesterase (svPDE) highlight its importance in venom actions
por: Pan, Cheng-Tsung, et al.
Publicado: (2023)

Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis
por: Egbert, Jeremy R., et al.
Publicado: (2016)

High expression of PDE4D correlates with poor prognosis and clinical progression in pancreaticductal adenocarcinoma
por: Liu, Fude, et al.
Publicado: (2019)

The ARL2 GTPase Is Required for Mitochondrial Morphology, Motility, and Maintenance of ATP Levels
por: Newman, Laura E., et al.
Publicado: (2014)

Functional Analysis of a c-di-AMP-specific Phosphodiesterase MsPDE from Mycobacterium smegmatis
por: Tang, Qing, et al.
Publicado: (2015)

Transmembrane redox control and proteolysis of PdeC, a novel type of c‐di‐GMP phosphodiesterase
por: Herbst, Susanne, et al.
Publicado: (2018)

Development of a New Radiofluorinated Quinoline Analog for PET Imaging of Phosphodiesterase 5 (PDE5) in Brain
por: Liu, Jianrong, et al.
Publicado: (2016)

Roflumilast, a Phosphodiesterases-4 (PDE4) Inhibitor, Alleviates Sepsis-induced Acute Kidney Injury
por: Xu, Xingkai, et al.
Publicado: (2020)

Phosphodiesterase 5 (PDE5) Is Highly Expressed in Cancer-Associated Fibroblasts and Enhances Breast Tumor Progression
por: Catalano, Stefania, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_46s762imjfa33rp7mmh4r9k2r6