Oxidative Stress and Lipid Accumulation Augments Cell Death in LDLR-Deficient RPE Cells and Ldlr (−/−) Mice

Lipid peroxidation from oxidative stress is considered a major contributor to age-related macular degeneration (AMD). The retina is abundant with circulating low-density lipoproteins (LDL), which are taken up by LDL receptor (LDLR) in the RPE and Müller cells. The purpose of this study is to investi...

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Detalles Bibliográficos
Autores principales: Sreekumar, Parameswaran Gangadharan, Su, Feng, Spee, Christine, Araujo, Eduardo, Nusinowitz, Steven, Reddy, Srinivasa T, Kannan, Ram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818299/
https://www.ncbi.nlm.nih.gov/pubmed/36611838
http://dx.doi.org/10.3390/cells12010043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818299/
https://www.ncbi.nlm.nih.gov/pubmed/36611838
http://dx.doi.org/10.3390/cells12010043

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