Pharmacodynamic Modeling to Evaluate the Impact of Cimetidine, an OCT2 Inhibitor, on the Anticancer Effects of Cisplatin

Despite potent anticancer activity, the clinical utilization of cisplatin is limited due to nephrotoxicity. As Organic Cation Transporter 2 (OCT2) has been shown to be one of the key transporters involved in the uptake of cisplatin into renal proximal tubules, OCT2 inhibitors such as cimetidine have...

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Detalles Bibliográficos
Autores principales: Mody, Hardik, Vaidya, Tanaya R., Lesko, Lawrence J., Ait-Oudhia, Sihem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818342/
https://www.ncbi.nlm.nih.gov/pubmed/36611850
http://dx.doi.org/10.3390/cells12010057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818342/
https://www.ncbi.nlm.nih.gov/pubmed/36611850
http://dx.doi.org/10.3390/cells12010057

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