Remarkable Synergy When Combining EZH2 Inhibitors with YM155 Is H3K27me3-Independent

SIMPLE SUMMARY: Systems biology analysis of gene expression across solid tumors identifies a 27 signature that centers on EZH2, the key component of polycomb repressive complex 2. Our study demonstrates that targeting the 27 gene network by the combination of BIRC5 and EZH2 inhibitors achieves remar...

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Detalles Bibliográficos
Autores principales: Yang, Jun, Davidoff, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818370/
https://www.ncbi.nlm.nih.gov/pubmed/36612203
http://dx.doi.org/10.3390/cancers15010208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818370/
https://www.ncbi.nlm.nih.gov/pubmed/36612203
http://dx.doi.org/10.3390/cancers15010208

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