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Remarkable Synergy When Combining EZH2 Inhibitors with YM155 Is H3K27me3-Independent
SIMPLE SUMMARY: Systems biology analysis of gene expression across solid tumors identifies a 27 signature that centers on EZH2, the key component of polycomb repressive complex 2. Our study demonstrates that targeting the 27 gene network by the combination of BIRC5 and EZH2 inhibitors achieves remar...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818370/ https://www.ncbi.nlm.nih.gov/pubmed/36612203 http://dx.doi.org/10.3390/cancers15010208 |