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Postoperative Survival and Clinical Outcomes for Uterine Leiomyosarcoma Spinal Bone Metastasis: A Case Series and Systematic Literature Review

Spinal bone metastases from uterine leiomyosarcoma (LMS) are relatively uncommon and few data are present in the literature. In this study, cases of nine consecutive patients who underwent spinal surgery for metastatic uterine LMS between 2012 and 2022 at a single institution were retrospectively re...

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Autores principales: Contartese, Deyanira, Bandiera, Stefano, Giavaresi, Gianluca, Borsari, Veronica, Griffoni, Cristiana, Gasbarrini, Alessandro, Fini, Milena, Salamanna, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818380/
https://www.ncbi.nlm.nih.gov/pubmed/36611309
http://dx.doi.org/10.3390/diagnostics13010015
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author Contartese, Deyanira
Bandiera, Stefano
Giavaresi, Gianluca
Borsari, Veronica
Griffoni, Cristiana
Gasbarrini, Alessandro
Fini, Milena
Salamanna, Francesca
author_facet Contartese, Deyanira
Bandiera, Stefano
Giavaresi, Gianluca
Borsari, Veronica
Griffoni, Cristiana
Gasbarrini, Alessandro
Fini, Milena
Salamanna, Francesca
author_sort Contartese, Deyanira
collection PubMed
description Spinal bone metastases from uterine leiomyosarcoma (LMS) are relatively uncommon and few data are present in the literature. In this study, cases of nine consecutive patients who underwent spinal surgery for metastatic uterine LMS between 2012 and 2022 at a single institution were retrospectively reviewed. The recorded demographic, operative, and postoperative factors were reviewed, and the functional outcomes were determined by changes in Frankel grade classification during follow-up. A systematic review of the literature was also performed to evaluate operative and postoperative factors and outcomes for patients with the same gynecological metastases to the spine. For our cases, the mean time between primary tumors to bone metastases diagnosis was 5.2 years, and the thoracic vertebrae were the most affected segment. Overall, median survival after diagnosis of metastatic spine lesions was 46 months. For the systematic review, the mean time between primary tumors to bone metastases was 4.9 years, with the lumbar spine as the most involved site of metastasis. Overall, median survival after diagnosis was 102 months. Once a spinal bone lesion from LMS is identified, surgical treatment can be beneficial and successful in alleviating symptoms. Further efforts will be crucial to identify prognostic markers as well as therapeutic targets to improve survival in these patients.
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spelling pubmed-98183802023-01-07 Postoperative Survival and Clinical Outcomes for Uterine Leiomyosarcoma Spinal Bone Metastasis: A Case Series and Systematic Literature Review Contartese, Deyanira Bandiera, Stefano Giavaresi, Gianluca Borsari, Veronica Griffoni, Cristiana Gasbarrini, Alessandro Fini, Milena Salamanna, Francesca Diagnostics (Basel) Article Spinal bone metastases from uterine leiomyosarcoma (LMS) are relatively uncommon and few data are present in the literature. In this study, cases of nine consecutive patients who underwent spinal surgery for metastatic uterine LMS between 2012 and 2022 at a single institution were retrospectively reviewed. The recorded demographic, operative, and postoperative factors were reviewed, and the functional outcomes were determined by changes in Frankel grade classification during follow-up. A systematic review of the literature was also performed to evaluate operative and postoperative factors and outcomes for patients with the same gynecological metastases to the spine. For our cases, the mean time between primary tumors to bone metastases diagnosis was 5.2 years, and the thoracic vertebrae were the most affected segment. Overall, median survival after diagnosis of metastatic spine lesions was 46 months. For the systematic review, the mean time between primary tumors to bone metastases was 4.9 years, with the lumbar spine as the most involved site of metastasis. Overall, median survival after diagnosis was 102 months. Once a spinal bone lesion from LMS is identified, surgical treatment can be beneficial and successful in alleviating symptoms. Further efforts will be crucial to identify prognostic markers as well as therapeutic targets to improve survival in these patients. MDPI 2022-12-21 /pmc/articles/PMC9818380/ /pubmed/36611309 http://dx.doi.org/10.3390/diagnostics13010015 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Contartese, Deyanira
Bandiera, Stefano
Giavaresi, Gianluca
Borsari, Veronica
Griffoni, Cristiana
Gasbarrini, Alessandro
Fini, Milena
Salamanna, Francesca
Postoperative Survival and Clinical Outcomes for Uterine Leiomyosarcoma Spinal Bone Metastasis: A Case Series and Systematic Literature Review
title Postoperative Survival and Clinical Outcomes for Uterine Leiomyosarcoma Spinal Bone Metastasis: A Case Series and Systematic Literature Review
title_full Postoperative Survival and Clinical Outcomes for Uterine Leiomyosarcoma Spinal Bone Metastasis: A Case Series and Systematic Literature Review
title_fullStr Postoperative Survival and Clinical Outcomes for Uterine Leiomyosarcoma Spinal Bone Metastasis: A Case Series and Systematic Literature Review
title_full_unstemmed Postoperative Survival and Clinical Outcomes for Uterine Leiomyosarcoma Spinal Bone Metastasis: A Case Series and Systematic Literature Review
title_short Postoperative Survival and Clinical Outcomes for Uterine Leiomyosarcoma Spinal Bone Metastasis: A Case Series and Systematic Literature Review
title_sort postoperative survival and clinical outcomes for uterine leiomyosarcoma spinal bone metastasis: a case series and systematic literature review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818380/
https://www.ncbi.nlm.nih.gov/pubmed/36611309
http://dx.doi.org/10.3390/diagnostics13010015
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