Beneficial Effect of ACI-24 Vaccination on Aβ Plaque Pathology and Microglial Phenotypes in an Amyloidosis Mouse Model

Amyloid-β (Aβ) deposition is an initiating factor in Alzheimer’s disease (AD). Microglia are the brain immune cells that surround and phagocytose Aβ plaques, but their phagocytic capacity declines in AD. This is in agreement with studies that associate AD risk loci with genes regulating the phagocyt...

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Detalles Bibliográficos
Autores principales: Rudan Njavro, Jasenka, Vukicevic, Marija, Fiorini, Emma, Dinkel, Lina, Müller, Stephan A., Berghofer, Anna, Bordier, Chiara, Kozlov, Stanislav, Halle, Annett, Buschmann, Katrin, Capell, Anja, Giudici, Camilla, Willem, Michael, Feederle, Regina, Lichtenthaler, Stefan F., Babolin, Chiara, Montanari, Paolo, Pfeifer, Andrea, Kosco-Vilbois, Marie, Tahirovic, Sabina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818422/
https://www.ncbi.nlm.nih.gov/pubmed/36611872
http://dx.doi.org/10.3390/cells12010079

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