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Primary Tumor Radiomic Model for Identifying Extrahepatic Metastasis of Hepatocellular Carcinoma Based on Contrast Enhanced Computed Tomography

This study aimed to identify radiomic features of primary tumor and develop a model for indicating extrahepatic metastasis of hepatocellular carcinoma (HCC). Contrast-enhanced computed tomographic (CT) images of 177 HCC cases, including 26 metastatic (MET) and 151 non-metastatic (non-MET), were retr...

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Autores principales: Chan, Lawrence Wing Chi, Wong, Sze Chuen Cesar, Cho, William Chi Shing, Huang, Mohan, Zhang, Fei, Chui, Man Lik, Lai, Una Ngo Yin, Chan, Tiffany Yuen Kwan, Cheung, Zoe Hoi Ching, Cheung, Jerry Chun Yin, Tang, Kin Fu, Tse, Man Long, Wong, Hung Kit, Kwok, Hugo Man Fung, Shen, Xinping, Zhang, Sailong, Chiu, Keith Wan Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818425/
https://www.ncbi.nlm.nih.gov/pubmed/36611394
http://dx.doi.org/10.3390/diagnostics13010102
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author Chan, Lawrence Wing Chi
Wong, Sze Chuen Cesar
Cho, William Chi Shing
Huang, Mohan
Zhang, Fei
Chui, Man Lik
Lai, Una Ngo Yin
Chan, Tiffany Yuen Kwan
Cheung, Zoe Hoi Ching
Cheung, Jerry Chun Yin
Tang, Kin Fu
Tse, Man Long
Wong, Hung Kit
Kwok, Hugo Man Fung
Shen, Xinping
Zhang, Sailong
Chiu, Keith Wan Hang
author_facet Chan, Lawrence Wing Chi
Wong, Sze Chuen Cesar
Cho, William Chi Shing
Huang, Mohan
Zhang, Fei
Chui, Man Lik
Lai, Una Ngo Yin
Chan, Tiffany Yuen Kwan
Cheung, Zoe Hoi Ching
Cheung, Jerry Chun Yin
Tang, Kin Fu
Tse, Man Long
Wong, Hung Kit
Kwok, Hugo Man Fung
Shen, Xinping
Zhang, Sailong
Chiu, Keith Wan Hang
author_sort Chan, Lawrence Wing Chi
collection PubMed
description This study aimed to identify radiomic features of primary tumor and develop a model for indicating extrahepatic metastasis of hepatocellular carcinoma (HCC). Contrast-enhanced computed tomographic (CT) images of 177 HCC cases, including 26 metastatic (MET) and 151 non-metastatic (non-MET), were retrospectively collected and analyzed. For each case, 851 radiomic features, which quantify shape, intensity, texture, and heterogeneity within the segmented volume of the largest HCC tumor in arterial phase, were extracted using Pyradiomics. The dataset was randomly split into training and test sets. Synthetic Minority Oversampling Technique (SMOTE) was performed to augment the training set to 145 MET and 145 non-MET cases. The test set consists of six MET and six non-MET cases. The external validation set is comprised of 20 MET and 25 non-MET cases collected from an independent clinical unit. Logistic regression and support vector machine (SVM) models were identified based on the features selected using the stepwise forward method while the deep convolution neural network, visual geometry group 16 (VGG16), was trained using CT images directly. Grey-level size zone matrix (GLSZM) features constitute four of eight selected predictors of metastasis due to their perceptiveness to the tumor heterogeneity. The radiomic logistic regression model yielded an area under receiver operating characteristic curve (AUROC) of 0.944 on the test set and an AUROC of 0.744 on the external validation set. Logistic regression revealed no significant difference with SVM in the performance and outperformed VGG16 significantly. As extrahepatic metastasis workups, such as chest CT and bone scintigraphy, are standard but exhaustive, radiomic model facilitates a cost-effective method for stratifying HCC patients into eligibility groups of these workups.
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spelling pubmed-98184252023-01-07 Primary Tumor Radiomic Model for Identifying Extrahepatic Metastasis of Hepatocellular Carcinoma Based on Contrast Enhanced Computed Tomography Chan, Lawrence Wing Chi Wong, Sze Chuen Cesar Cho, William Chi Shing Huang, Mohan Zhang, Fei Chui, Man Lik Lai, Una Ngo Yin Chan, Tiffany Yuen Kwan Cheung, Zoe Hoi Ching Cheung, Jerry Chun Yin Tang, Kin Fu Tse, Man Long Wong, Hung Kit Kwok, Hugo Man Fung Shen, Xinping Zhang, Sailong Chiu, Keith Wan Hang Diagnostics (Basel) Article This study aimed to identify radiomic features of primary tumor and develop a model for indicating extrahepatic metastasis of hepatocellular carcinoma (HCC). Contrast-enhanced computed tomographic (CT) images of 177 HCC cases, including 26 metastatic (MET) and 151 non-metastatic (non-MET), were retrospectively collected and analyzed. For each case, 851 radiomic features, which quantify shape, intensity, texture, and heterogeneity within the segmented volume of the largest HCC tumor in arterial phase, were extracted using Pyradiomics. The dataset was randomly split into training and test sets. Synthetic Minority Oversampling Technique (SMOTE) was performed to augment the training set to 145 MET and 145 non-MET cases. The test set consists of six MET and six non-MET cases. The external validation set is comprised of 20 MET and 25 non-MET cases collected from an independent clinical unit. Logistic regression and support vector machine (SVM) models were identified based on the features selected using the stepwise forward method while the deep convolution neural network, visual geometry group 16 (VGG16), was trained using CT images directly. Grey-level size zone matrix (GLSZM) features constitute four of eight selected predictors of metastasis due to their perceptiveness to the tumor heterogeneity. The radiomic logistic regression model yielded an area under receiver operating characteristic curve (AUROC) of 0.944 on the test set and an AUROC of 0.744 on the external validation set. Logistic regression revealed no significant difference with SVM in the performance and outperformed VGG16 significantly. As extrahepatic metastasis workups, such as chest CT and bone scintigraphy, are standard but exhaustive, radiomic model facilitates a cost-effective method for stratifying HCC patients into eligibility groups of these workups. MDPI 2022-12-29 /pmc/articles/PMC9818425/ /pubmed/36611394 http://dx.doi.org/10.3390/diagnostics13010102 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chan, Lawrence Wing Chi
Wong, Sze Chuen Cesar
Cho, William Chi Shing
Huang, Mohan
Zhang, Fei
Chui, Man Lik
Lai, Una Ngo Yin
Chan, Tiffany Yuen Kwan
Cheung, Zoe Hoi Ching
Cheung, Jerry Chun Yin
Tang, Kin Fu
Tse, Man Long
Wong, Hung Kit
Kwok, Hugo Man Fung
Shen, Xinping
Zhang, Sailong
Chiu, Keith Wan Hang
Primary Tumor Radiomic Model for Identifying Extrahepatic Metastasis of Hepatocellular Carcinoma Based on Contrast Enhanced Computed Tomography
title Primary Tumor Radiomic Model for Identifying Extrahepatic Metastasis of Hepatocellular Carcinoma Based on Contrast Enhanced Computed Tomography
title_full Primary Tumor Radiomic Model for Identifying Extrahepatic Metastasis of Hepatocellular Carcinoma Based on Contrast Enhanced Computed Tomography
title_fullStr Primary Tumor Radiomic Model for Identifying Extrahepatic Metastasis of Hepatocellular Carcinoma Based on Contrast Enhanced Computed Tomography
title_full_unstemmed Primary Tumor Radiomic Model for Identifying Extrahepatic Metastasis of Hepatocellular Carcinoma Based on Contrast Enhanced Computed Tomography
title_short Primary Tumor Radiomic Model for Identifying Extrahepatic Metastasis of Hepatocellular Carcinoma Based on Contrast Enhanced Computed Tomography
title_sort primary tumor radiomic model for identifying extrahepatic metastasis of hepatocellular carcinoma based on contrast enhanced computed tomography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818425/
https://www.ncbi.nlm.nih.gov/pubmed/36611394
http://dx.doi.org/10.3390/diagnostics13010102
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