Fullerenols Prevent Neuron Death and Reduce Oxidative Stress in Drosophila Huntington’s Disease Model

Huntington’s disease (HD) is one of the human neurodegenerative diseases for which there is no effective treatment. Therefore, there is a strong demand for a novel neuroprotective agent that can alleviate its course. Fullerene derivatives are considered to be such agents; however, they need to be co...

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Autores principales: Bolshakova, Olga I., Borisenkova, Alina A., Golomidov, Ilya M., Komissarov, Artem E., Slobodina, Alexandra D., Ryabova, Elena V., Ryabokon, Irina S., Latypova, Evgenia M., Slepneva, Elizaveta E., Sarantseva, Svetlana V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818496/
https://www.ncbi.nlm.nih.gov/pubmed/36611963
http://dx.doi.org/10.3390/cells12010170
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author Bolshakova, Olga I.
Borisenkova, Alina A.
Golomidov, Ilya M.
Komissarov, Artem E.
Slobodina, Alexandra D.
Ryabova, Elena V.
Ryabokon, Irina S.
Latypova, Evgenia M.
Slepneva, Elizaveta E.
Sarantseva, Svetlana V.
author_facet Bolshakova, Olga I.
Borisenkova, Alina A.
Golomidov, Ilya M.
Komissarov, Artem E.
Slobodina, Alexandra D.
Ryabova, Elena V.
Ryabokon, Irina S.
Latypova, Evgenia M.
Slepneva, Elizaveta E.
Sarantseva, Svetlana V.
author_sort Bolshakova, Olga I.
collection PubMed
description Huntington’s disease (HD) is one of the human neurodegenerative diseases for which there is no effective treatment. Therefore, there is a strong demand for a novel neuroprotective agent that can alleviate its course. Fullerene derivatives are considered to be such agents; however, they need to be comprehensively investigated in model organisms. In this work, neuroprotective activity of C(60)(OH)(30) and C(120)O(OH)(44) fullerenols was analyzed for the first time in a Drosophila transgenic model of HD. Lifespan, behavior, oxidative stress level and age-related neurodegeneration were assessed in flies with the pathogenic Huntingtin protein expression in nerve cells. Feed supplementation with hydroxylated C(60) fullerene and C(120)O dimer oxide molecules was shown to diminish the oxidative stress level and neurodegenerative processes in the flies’ brains. Thus, fullerenes displayed neuroprotective activity in this model.
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spelling pubmed-98184962023-01-07 Fullerenols Prevent Neuron Death and Reduce Oxidative Stress in Drosophila Huntington’s Disease Model Bolshakova, Olga I. Borisenkova, Alina A. Golomidov, Ilya M. Komissarov, Artem E. Slobodina, Alexandra D. Ryabova, Elena V. Ryabokon, Irina S. Latypova, Evgenia M. Slepneva, Elizaveta E. Sarantseva, Svetlana V. Cells Article Huntington’s disease (HD) is one of the human neurodegenerative diseases for which there is no effective treatment. Therefore, there is a strong demand for a novel neuroprotective agent that can alleviate its course. Fullerene derivatives are considered to be such agents; however, they need to be comprehensively investigated in model organisms. In this work, neuroprotective activity of C(60)(OH)(30) and C(120)O(OH)(44) fullerenols was analyzed for the first time in a Drosophila transgenic model of HD. Lifespan, behavior, oxidative stress level and age-related neurodegeneration were assessed in flies with the pathogenic Huntingtin protein expression in nerve cells. Feed supplementation with hydroxylated C(60) fullerene and C(120)O dimer oxide molecules was shown to diminish the oxidative stress level and neurodegenerative processes in the flies’ brains. Thus, fullerenes displayed neuroprotective activity in this model. MDPI 2022-12-31 /pmc/articles/PMC9818496/ /pubmed/36611963 http://dx.doi.org/10.3390/cells12010170 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bolshakova, Olga I.
Borisenkova, Alina A.
Golomidov, Ilya M.
Komissarov, Artem E.
Slobodina, Alexandra D.
Ryabova, Elena V.
Ryabokon, Irina S.
Latypova, Evgenia M.
Slepneva, Elizaveta E.
Sarantseva, Svetlana V.
Fullerenols Prevent Neuron Death and Reduce Oxidative Stress in Drosophila Huntington’s Disease Model
title Fullerenols Prevent Neuron Death and Reduce Oxidative Stress in Drosophila Huntington’s Disease Model
title_full Fullerenols Prevent Neuron Death and Reduce Oxidative Stress in Drosophila Huntington’s Disease Model
title_fullStr Fullerenols Prevent Neuron Death and Reduce Oxidative Stress in Drosophila Huntington’s Disease Model
title_full_unstemmed Fullerenols Prevent Neuron Death and Reduce Oxidative Stress in Drosophila Huntington’s Disease Model
title_short Fullerenols Prevent Neuron Death and Reduce Oxidative Stress in Drosophila Huntington’s Disease Model
title_sort fullerenols prevent neuron death and reduce oxidative stress in drosophila huntington’s disease model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818496/
https://www.ncbi.nlm.nih.gov/pubmed/36611963
http://dx.doi.org/10.3390/cells12010170
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