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Establishing Normative Values to Determine the Prevalence of Biochemical Hyperandrogenism in Premenopausal Women of Different Ethnicities from Eastern Siberia

Androgen assessment is a key element for diagnosing polycystic ovary syndrome (PCOS), and defining a “normal” level of circulating androgens is critical for epidemiological studies. We determined the upper normal limits (UNLs) for androgens in a population-based group of premenopausal “healthy contr...

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Autores principales: Suturina, Larisa, Lizneva, Daria, Atalyan, Alina, Lazareva, Ludmila, Belskikh, Aleksey, Bairova, Tatyana, Sholokhov, Leonid, Rashidova, Maria, Danusevich, Irina, Nadeliaeva, Iana, Belenkaya, Lilia, Darzhaev, Zorikto, Sharifulin, Eldar, Belkova, Natalia, Igumnov, Ilia, Trofimova, Tatyana, Khomyakova, Anastasiya, Ievleva, Kseniia, Babaeva, Natalia, Egorova, Irina, Salimova, Madinabonu, Yildiz, Bulent O., Legro, Richard S., Stanczyk, Frank Z., Azziz, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818891/
https://www.ncbi.nlm.nih.gov/pubmed/36611327
http://dx.doi.org/10.3390/diagnostics13010033
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author Suturina, Larisa
Lizneva, Daria
Atalyan, Alina
Lazareva, Ludmila
Belskikh, Aleksey
Bairova, Tatyana
Sholokhov, Leonid
Rashidova, Maria
Danusevich, Irina
Nadeliaeva, Iana
Belenkaya, Lilia
Darzhaev, Zorikto
Sharifulin, Eldar
Belkova, Natalia
Igumnov, Ilia
Trofimova, Tatyana
Khomyakova, Anastasiya
Ievleva, Kseniia
Babaeva, Natalia
Egorova, Irina
Salimova, Madinabonu
Yildiz, Bulent O.
Legro, Richard S.
Stanczyk, Frank Z.
Azziz, Ricardo
author_facet Suturina, Larisa
Lizneva, Daria
Atalyan, Alina
Lazareva, Ludmila
Belskikh, Aleksey
Bairova, Tatyana
Sholokhov, Leonid
Rashidova, Maria
Danusevich, Irina
Nadeliaeva, Iana
Belenkaya, Lilia
Darzhaev, Zorikto
Sharifulin, Eldar
Belkova, Natalia
Igumnov, Ilia
Trofimova, Tatyana
Khomyakova, Anastasiya
Ievleva, Kseniia
Babaeva, Natalia
Egorova, Irina
Salimova, Madinabonu
Yildiz, Bulent O.
Legro, Richard S.
Stanczyk, Frank Z.
Azziz, Ricardo
author_sort Suturina, Larisa
collection PubMed
description Androgen assessment is a key element for diagnosing polycystic ovary syndrome (PCOS), and defining a “normal” level of circulating androgens is critical for epidemiological studies. We determined the upper normal limits (UNLs) for androgens in a population-based group of premenopausal “healthy control” women, overall and by ethnicity (Caucasian and Asian), in the cross-sectional Eastern Siberia PCOS Epidemiology and Phenotype (ESPEP) Study (ClinicalTrials.gov ID: NCT05194384) conducted in 2016–2019. Overall, we identified a “healthy control” group consisting of 143 healthy premenopausal women without menstrual dysfunction, hirsutism, polycystic ovaries, or medical disorders. We analyzed serum total testosterone (TT) by using liquid chromatography with tandem mass spectrometry (LC-MS/MS), and DHEAS, sex-hormone-binding globulin (SHBG), TSH, prolactin, and 17-hydroxyprogesterone (17OHP) were assessed with an enzyme-linked immunosorbent assay (ELISA). The UNLs for the entire population for the TT, free androgen index (FAI), and DHEAS were determined as the 98th percentiles in healthy controls as follows: 67.3 (95% confidence interval (CI): 48.1, 76.5) ng/dl, 5.4 (3.5, 14.0), and 355 (289, 371) μg/dl, respectively. The study results demonstrated that the UNLs for TT and FAI varied by ethnicity, whereas the DHEAS UNLs were comparable in the ethnicities studied.
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spelling pubmed-98188912023-01-07 Establishing Normative Values to Determine the Prevalence of Biochemical Hyperandrogenism in Premenopausal Women of Different Ethnicities from Eastern Siberia Suturina, Larisa Lizneva, Daria Atalyan, Alina Lazareva, Ludmila Belskikh, Aleksey Bairova, Tatyana Sholokhov, Leonid Rashidova, Maria Danusevich, Irina Nadeliaeva, Iana Belenkaya, Lilia Darzhaev, Zorikto Sharifulin, Eldar Belkova, Natalia Igumnov, Ilia Trofimova, Tatyana Khomyakova, Anastasiya Ievleva, Kseniia Babaeva, Natalia Egorova, Irina Salimova, Madinabonu Yildiz, Bulent O. Legro, Richard S. Stanczyk, Frank Z. Azziz, Ricardo Diagnostics (Basel) Article Androgen assessment is a key element for diagnosing polycystic ovary syndrome (PCOS), and defining a “normal” level of circulating androgens is critical for epidemiological studies. We determined the upper normal limits (UNLs) for androgens in a population-based group of premenopausal “healthy control” women, overall and by ethnicity (Caucasian and Asian), in the cross-sectional Eastern Siberia PCOS Epidemiology and Phenotype (ESPEP) Study (ClinicalTrials.gov ID: NCT05194384) conducted in 2016–2019. Overall, we identified a “healthy control” group consisting of 143 healthy premenopausal women without menstrual dysfunction, hirsutism, polycystic ovaries, or medical disorders. We analyzed serum total testosterone (TT) by using liquid chromatography with tandem mass spectrometry (LC-MS/MS), and DHEAS, sex-hormone-binding globulin (SHBG), TSH, prolactin, and 17-hydroxyprogesterone (17OHP) were assessed with an enzyme-linked immunosorbent assay (ELISA). The UNLs for the entire population for the TT, free androgen index (FAI), and DHEAS were determined as the 98th percentiles in healthy controls as follows: 67.3 (95% confidence interval (CI): 48.1, 76.5) ng/dl, 5.4 (3.5, 14.0), and 355 (289, 371) μg/dl, respectively. The study results demonstrated that the UNLs for TT and FAI varied by ethnicity, whereas the DHEAS UNLs were comparable in the ethnicities studied. MDPI 2022-12-22 /pmc/articles/PMC9818891/ /pubmed/36611327 http://dx.doi.org/10.3390/diagnostics13010033 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Suturina, Larisa
Lizneva, Daria
Atalyan, Alina
Lazareva, Ludmila
Belskikh, Aleksey
Bairova, Tatyana
Sholokhov, Leonid
Rashidova, Maria
Danusevich, Irina
Nadeliaeva, Iana
Belenkaya, Lilia
Darzhaev, Zorikto
Sharifulin, Eldar
Belkova, Natalia
Igumnov, Ilia
Trofimova, Tatyana
Khomyakova, Anastasiya
Ievleva, Kseniia
Babaeva, Natalia
Egorova, Irina
Salimova, Madinabonu
Yildiz, Bulent O.
Legro, Richard S.
Stanczyk, Frank Z.
Azziz, Ricardo
Establishing Normative Values to Determine the Prevalence of Biochemical Hyperandrogenism in Premenopausal Women of Different Ethnicities from Eastern Siberia
title Establishing Normative Values to Determine the Prevalence of Biochemical Hyperandrogenism in Premenopausal Women of Different Ethnicities from Eastern Siberia
title_full Establishing Normative Values to Determine the Prevalence of Biochemical Hyperandrogenism in Premenopausal Women of Different Ethnicities from Eastern Siberia
title_fullStr Establishing Normative Values to Determine the Prevalence of Biochemical Hyperandrogenism in Premenopausal Women of Different Ethnicities from Eastern Siberia
title_full_unstemmed Establishing Normative Values to Determine the Prevalence of Biochemical Hyperandrogenism in Premenopausal Women of Different Ethnicities from Eastern Siberia
title_short Establishing Normative Values to Determine the Prevalence of Biochemical Hyperandrogenism in Premenopausal Women of Different Ethnicities from Eastern Siberia
title_sort establishing normative values to determine the prevalence of biochemical hyperandrogenism in premenopausal women of different ethnicities from eastern siberia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818891/
https://www.ncbi.nlm.nih.gov/pubmed/36611327
http://dx.doi.org/10.3390/diagnostics13010033
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