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Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease

The kidney contains many mitochondria that generate ATP to provide energy for cellular processes. Oxidative stress injury can be caused by impaired mitochondria with excessive levels of reactive oxygen species. Accumulating evidence has indicated a relationship between oxidative stress and kidney di...

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Autores principales: Ho, Hsin-Jung, Shirakawa, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818928/
https://www.ncbi.nlm.nih.gov/pubmed/36611880
http://dx.doi.org/10.3390/cells12010088
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author Ho, Hsin-Jung
Shirakawa, Hitoshi
author_facet Ho, Hsin-Jung
Shirakawa, Hitoshi
author_sort Ho, Hsin-Jung
collection PubMed
description The kidney contains many mitochondria that generate ATP to provide energy for cellular processes. Oxidative stress injury can be caused by impaired mitochondria with excessive levels of reactive oxygen species. Accumulating evidence has indicated a relationship between oxidative stress and kidney diseases, and revealed new insights into mitochondria-targeted therapeutics for renal injury. Improving mitochondrial homeostasis, increasing mitochondrial biogenesis, and balancing mitochondrial turnover has the potential to protect renal function against oxidative stress. Although there are some reviews that addressed this issue, the articles summarizing the relationship between mitochondria-targeted effects and the risk factors of renal failure are still few. In this review, we integrate recent studies on oxidative stress and mitochondrial function in kidney diseases, especially chronic kidney disease. We organized the causes and risk factors of oxidative stress in the kidneys based in their mitochondria-targeted effects. This review also listed the possible candidates for clinical therapeutics of kidney diseases by modulating mitochondrial function.
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spelling pubmed-98189282023-01-07 Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease Ho, Hsin-Jung Shirakawa, Hitoshi Cells Review The kidney contains many mitochondria that generate ATP to provide energy for cellular processes. Oxidative stress injury can be caused by impaired mitochondria with excessive levels of reactive oxygen species. Accumulating evidence has indicated a relationship between oxidative stress and kidney diseases, and revealed new insights into mitochondria-targeted therapeutics for renal injury. Improving mitochondrial homeostasis, increasing mitochondrial biogenesis, and balancing mitochondrial turnover has the potential to protect renal function against oxidative stress. Although there are some reviews that addressed this issue, the articles summarizing the relationship between mitochondria-targeted effects and the risk factors of renal failure are still few. In this review, we integrate recent studies on oxidative stress and mitochondrial function in kidney diseases, especially chronic kidney disease. We organized the causes and risk factors of oxidative stress in the kidneys based in their mitochondria-targeted effects. This review also listed the possible candidates for clinical therapeutics of kidney diseases by modulating mitochondrial function. MDPI 2022-12-25 /pmc/articles/PMC9818928/ /pubmed/36611880 http://dx.doi.org/10.3390/cells12010088 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ho, Hsin-Jung
Shirakawa, Hitoshi
Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease
title Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease
title_full Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease
title_fullStr Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease
title_full_unstemmed Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease
title_short Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease
title_sort oxidative stress and mitochondrial dysfunction in chronic kidney disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818928/
https://www.ncbi.nlm.nih.gov/pubmed/36611880
http://dx.doi.org/10.3390/cells12010088
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