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Contemporary Trends in Malignant Peritoneal Mesothelioma: Incidence and Survival in the United States

SIMPLE SUMMARY: This contemporary epidemiological analysis revealed a stable overall incidence of malignant peritoneal mesothelioma (MPM), but improved recognition of epithelioid histology. Survival improved over time and was associated with cancer-directed surgery, suggesting that accurate diagnosi...

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Autores principales: Calthorpe, Lucia, Romero-Hernandez, Fernanda, Miller, Phoebe, Conroy, Patricia C., Hirose, Kenzo, Kim, Alex, Kirkwood, Kimberly, Nakakura, Eric, Corvera, Carlos, Maker, Ajay V., Alseidi, Adnan, Adam, Mohamed Abdelgadir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818958/
https://www.ncbi.nlm.nih.gov/pubmed/36612225
http://dx.doi.org/10.3390/cancers15010229
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author Calthorpe, Lucia
Romero-Hernandez, Fernanda
Miller, Phoebe
Conroy, Patricia C.
Hirose, Kenzo
Kim, Alex
Kirkwood, Kimberly
Nakakura, Eric
Corvera, Carlos
Maker, Ajay V.
Alseidi, Adnan
Adam, Mohamed Abdelgadir
author_facet Calthorpe, Lucia
Romero-Hernandez, Fernanda
Miller, Phoebe
Conroy, Patricia C.
Hirose, Kenzo
Kim, Alex
Kirkwood, Kimberly
Nakakura, Eric
Corvera, Carlos
Maker, Ajay V.
Alseidi, Adnan
Adam, Mohamed Abdelgadir
author_sort Calthorpe, Lucia
collection PubMed
description SIMPLE SUMMARY: This contemporary epidemiological analysis revealed a stable overall incidence of malignant peritoneal mesothelioma (MPM), but improved recognition of epithelioid histology. Survival improved over time and was associated with cancer-directed surgery, suggesting that accurate diagnosis of epithelioid histology may lead to more patients being considered for appropriate multimodal treatment and contribute to improved overall survival. ABSTRACT: Background: Malignant peritoneal mesothelioma (MPM) is a rare disease with a historically poor prognosis. Given the emergence of effective therapies, a contemporary analysis of MPM incidence and survival is warranted. Methods: The SEER-18 registry dataset was analyzed (2000–2018). Age-adjusted annual incidence was stratified by sex and histology. Joinpoint regression was used to estimate annual percent change (APC) in incidence. Multivariable cox proportional hazards models were used to investigate survival trends. Results: Of 1689 MPM cases, most were male (55.4%), >50 years (80.0%), and white (75.2%). Age-adjusted incidence of MPM remained stable over time, with an average annual incidence of 1.02 cases/million. Epithelioid histology increased by 240% (APC 2.6; 95% CI: 0.7, 4.5), while incidence of undefined histology decreased significantly (APC −2.1; 95% CI: −3.1, −1.1). Cases treated with cancer-directed surgery increased from 27% to 43%. Overall median age-standardized survival was 11.6 months. Median age-standardized survival was 16.6 months for epithelioid histology but 2.0 months for sarcomatoid histology. Diagnosis in recent years (2015–2018 HR 0.51; 95% CI: 0.38, 0.67) and receipt of cancer-directed surgery (HR 0.84; 95% CI: 0.72, 0.98) were associated with improved survival. Conclusions: Although the overall incidence of MPM remained stable, recognition of epithelioid histology increased. Concurrent with an increase in cancer-directed surgery, MPM survival has improved.
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spelling pubmed-98189582023-01-07 Contemporary Trends in Malignant Peritoneal Mesothelioma: Incidence and Survival in the United States Calthorpe, Lucia Romero-Hernandez, Fernanda Miller, Phoebe Conroy, Patricia C. Hirose, Kenzo Kim, Alex Kirkwood, Kimberly Nakakura, Eric Corvera, Carlos Maker, Ajay V. Alseidi, Adnan Adam, Mohamed Abdelgadir Cancers (Basel) Article SIMPLE SUMMARY: This contemporary epidemiological analysis revealed a stable overall incidence of malignant peritoneal mesothelioma (MPM), but improved recognition of epithelioid histology. Survival improved over time and was associated with cancer-directed surgery, suggesting that accurate diagnosis of epithelioid histology may lead to more patients being considered for appropriate multimodal treatment and contribute to improved overall survival. ABSTRACT: Background: Malignant peritoneal mesothelioma (MPM) is a rare disease with a historically poor prognosis. Given the emergence of effective therapies, a contemporary analysis of MPM incidence and survival is warranted. Methods: The SEER-18 registry dataset was analyzed (2000–2018). Age-adjusted annual incidence was stratified by sex and histology. Joinpoint regression was used to estimate annual percent change (APC) in incidence. Multivariable cox proportional hazards models were used to investigate survival trends. Results: Of 1689 MPM cases, most were male (55.4%), >50 years (80.0%), and white (75.2%). Age-adjusted incidence of MPM remained stable over time, with an average annual incidence of 1.02 cases/million. Epithelioid histology increased by 240% (APC 2.6; 95% CI: 0.7, 4.5), while incidence of undefined histology decreased significantly (APC −2.1; 95% CI: −3.1, −1.1). Cases treated with cancer-directed surgery increased from 27% to 43%. Overall median age-standardized survival was 11.6 months. Median age-standardized survival was 16.6 months for epithelioid histology but 2.0 months for sarcomatoid histology. Diagnosis in recent years (2015–2018 HR 0.51; 95% CI: 0.38, 0.67) and receipt of cancer-directed surgery (HR 0.84; 95% CI: 0.72, 0.98) were associated with improved survival. Conclusions: Although the overall incidence of MPM remained stable, recognition of epithelioid histology increased. Concurrent with an increase in cancer-directed surgery, MPM survival has improved. MDPI 2022-12-30 /pmc/articles/PMC9818958/ /pubmed/36612225 http://dx.doi.org/10.3390/cancers15010229 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Calthorpe, Lucia
Romero-Hernandez, Fernanda
Miller, Phoebe
Conroy, Patricia C.
Hirose, Kenzo
Kim, Alex
Kirkwood, Kimberly
Nakakura, Eric
Corvera, Carlos
Maker, Ajay V.
Alseidi, Adnan
Adam, Mohamed Abdelgadir
Contemporary Trends in Malignant Peritoneal Mesothelioma: Incidence and Survival in the United States
title Contemporary Trends in Malignant Peritoneal Mesothelioma: Incidence and Survival in the United States
title_full Contemporary Trends in Malignant Peritoneal Mesothelioma: Incidence and Survival in the United States
title_fullStr Contemporary Trends in Malignant Peritoneal Mesothelioma: Incidence and Survival in the United States
title_full_unstemmed Contemporary Trends in Malignant Peritoneal Mesothelioma: Incidence and Survival in the United States
title_short Contemporary Trends in Malignant Peritoneal Mesothelioma: Incidence and Survival in the United States
title_sort contemporary trends in malignant peritoneal mesothelioma: incidence and survival in the united states
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818958/
https://www.ncbi.nlm.nih.gov/pubmed/36612225
http://dx.doi.org/10.3390/cancers15010229
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