Cargando…

Ten-Year Probabilities of Death Due to Cancer and Cardiovascular Disease among Breast Cancer Patients Diagnosed in North-Eastern Spain

Mortality from cardiovascular disease (CVD), second tumours, and other causes is of clinical interest in the long-term follow-up of breast cancer (BC) patients. Using a cohort of BC patients (N = 6758) from the cancer registries of Girona and Tarragona (north-eastern Spain), we studied the 10-year p...

Descripción completa

Detalles Bibliográficos
Autores principales: Clèries, Ramon, Ameijide, Alberto, Buxó, Maria, Vilardell, Mireia, Martínez, José Miguel, Font, Rebeca, Marcos-Gragera, Rafael, Puigdemont, Montse, Viñas, Gemma, Carulla, Marià, Espinàs, Josep Alfons, Galceran, Jaume, Izquierdo, Ángel, Borràs, Josep Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9819018/
https://www.ncbi.nlm.nih.gov/pubmed/36612726
http://dx.doi.org/10.3390/ijerph20010405
_version_ 1784865127884914688
author Clèries, Ramon
Ameijide, Alberto
Buxó, Maria
Vilardell, Mireia
Martínez, José Miguel
Font, Rebeca
Marcos-Gragera, Rafael
Puigdemont, Montse
Viñas, Gemma
Carulla, Marià
Espinàs, Josep Alfons
Galceran, Jaume
Izquierdo, Ángel
Borràs, Josep Maria
author_facet Clèries, Ramon
Ameijide, Alberto
Buxó, Maria
Vilardell, Mireia
Martínez, José Miguel
Font, Rebeca
Marcos-Gragera, Rafael
Puigdemont, Montse
Viñas, Gemma
Carulla, Marià
Espinàs, Josep Alfons
Galceran, Jaume
Izquierdo, Ángel
Borràs, Josep Maria
author_sort Clèries, Ramon
collection PubMed
description Mortality from cardiovascular disease (CVD), second tumours, and other causes is of clinical interest in the long-term follow-up of breast cancer (BC) patients. Using a cohort of BC patients (N = 6758) from the cancer registries of Girona and Tarragona (north-eastern Spain), we studied the 10-year probabilities of death due to BC, other cancers, and CVD according to stage at diagnosis and hormone receptor (HR) status. Among the non-BC causes of death (N = 720), CVD (N = 218) surpassed other cancers (N = 196). The BC cohort presented a significantly higher risk of death due to endometrial and ovarian cancers than the general population. In Stage I, HR− patients showed a 1.72-fold higher probability of all-cause death and a 6.11-fold higher probability of breast cancer death than HR+ patients. In Stages II–III, the probability of CVD death (range 3.11% to 3.86%) surpassed that of other cancers (range 0.54% to 3.11%). In Stage IV patients, the probability of death from any cancer drove the mortality risk. Promoting screening and preventive measures in BC patients are warranted, since long-term control should encompass early detection of second neoplasms, ruling out the possibility of late recurrence. In patients diagnosed in Stages II–III at an older age, surveillance for preventing late cardiotoxicity is crucial.
format Online
Article
Text
id pubmed-9819018
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98190182023-01-07 Ten-Year Probabilities of Death Due to Cancer and Cardiovascular Disease among Breast Cancer Patients Diagnosed in North-Eastern Spain Clèries, Ramon Ameijide, Alberto Buxó, Maria Vilardell, Mireia Martínez, José Miguel Font, Rebeca Marcos-Gragera, Rafael Puigdemont, Montse Viñas, Gemma Carulla, Marià Espinàs, Josep Alfons Galceran, Jaume Izquierdo, Ángel Borràs, Josep Maria Int J Environ Res Public Health Article Mortality from cardiovascular disease (CVD), second tumours, and other causes is of clinical interest in the long-term follow-up of breast cancer (BC) patients. Using a cohort of BC patients (N = 6758) from the cancer registries of Girona and Tarragona (north-eastern Spain), we studied the 10-year probabilities of death due to BC, other cancers, and CVD according to stage at diagnosis and hormone receptor (HR) status. Among the non-BC causes of death (N = 720), CVD (N = 218) surpassed other cancers (N = 196). The BC cohort presented a significantly higher risk of death due to endometrial and ovarian cancers than the general population. In Stage I, HR− patients showed a 1.72-fold higher probability of all-cause death and a 6.11-fold higher probability of breast cancer death than HR+ patients. In Stages II–III, the probability of CVD death (range 3.11% to 3.86%) surpassed that of other cancers (range 0.54% to 3.11%). In Stage IV patients, the probability of death from any cancer drove the mortality risk. Promoting screening and preventive measures in BC patients are warranted, since long-term control should encompass early detection of second neoplasms, ruling out the possibility of late recurrence. In patients diagnosed in Stages II–III at an older age, surveillance for preventing late cardiotoxicity is crucial. MDPI 2022-12-27 /pmc/articles/PMC9819018/ /pubmed/36612726 http://dx.doi.org/10.3390/ijerph20010405 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Clèries, Ramon
Ameijide, Alberto
Buxó, Maria
Vilardell, Mireia
Martínez, José Miguel
Font, Rebeca
Marcos-Gragera, Rafael
Puigdemont, Montse
Viñas, Gemma
Carulla, Marià
Espinàs, Josep Alfons
Galceran, Jaume
Izquierdo, Ángel
Borràs, Josep Maria
Ten-Year Probabilities of Death Due to Cancer and Cardiovascular Disease among Breast Cancer Patients Diagnosed in North-Eastern Spain
title Ten-Year Probabilities of Death Due to Cancer and Cardiovascular Disease among Breast Cancer Patients Diagnosed in North-Eastern Spain
title_full Ten-Year Probabilities of Death Due to Cancer and Cardiovascular Disease among Breast Cancer Patients Diagnosed in North-Eastern Spain
title_fullStr Ten-Year Probabilities of Death Due to Cancer and Cardiovascular Disease among Breast Cancer Patients Diagnosed in North-Eastern Spain
title_full_unstemmed Ten-Year Probabilities of Death Due to Cancer and Cardiovascular Disease among Breast Cancer Patients Diagnosed in North-Eastern Spain
title_short Ten-Year Probabilities of Death Due to Cancer and Cardiovascular Disease among Breast Cancer Patients Diagnosed in North-Eastern Spain
title_sort ten-year probabilities of death due to cancer and cardiovascular disease among breast cancer patients diagnosed in north-eastern spain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9819018/
https://www.ncbi.nlm.nih.gov/pubmed/36612726
http://dx.doi.org/10.3390/ijerph20010405
work_keys_str_mv AT cleriesramon tenyearprobabilitiesofdeathduetocancerandcardiovasculardiseaseamongbreastcancerpatientsdiagnosedinnortheasternspain
AT ameijidealberto tenyearprobabilitiesofdeathduetocancerandcardiovasculardiseaseamongbreastcancerpatientsdiagnosedinnortheasternspain
AT buxomaria tenyearprobabilitiesofdeathduetocancerandcardiovasculardiseaseamongbreastcancerpatientsdiagnosedinnortheasternspain
AT vilardellmireia tenyearprobabilitiesofdeathduetocancerandcardiovasculardiseaseamongbreastcancerpatientsdiagnosedinnortheasternspain
AT martinezjosemiguel tenyearprobabilitiesofdeathduetocancerandcardiovasculardiseaseamongbreastcancerpatientsdiagnosedinnortheasternspain
AT fontrebeca tenyearprobabilitiesofdeathduetocancerandcardiovasculardiseaseamongbreastcancerpatientsdiagnosedinnortheasternspain
AT marcosgragerarafael tenyearprobabilitiesofdeathduetocancerandcardiovasculardiseaseamongbreastcancerpatientsdiagnosedinnortheasternspain
AT puigdemontmontse tenyearprobabilitiesofdeathduetocancerandcardiovasculardiseaseamongbreastcancerpatientsdiagnosedinnortheasternspain
AT vinasgemma tenyearprobabilitiesofdeathduetocancerandcardiovasculardiseaseamongbreastcancerpatientsdiagnosedinnortheasternspain
AT carullamaria tenyearprobabilitiesofdeathduetocancerandcardiovasculardiseaseamongbreastcancerpatientsdiagnosedinnortheasternspain
AT espinasjosepalfons tenyearprobabilitiesofdeathduetocancerandcardiovasculardiseaseamongbreastcancerpatientsdiagnosedinnortheasternspain
AT galceranjaume tenyearprobabilitiesofdeathduetocancerandcardiovasculardiseaseamongbreastcancerpatientsdiagnosedinnortheasternspain
AT izquierdoangel tenyearprobabilitiesofdeathduetocancerandcardiovasculardiseaseamongbreastcancerpatientsdiagnosedinnortheasternspain
AT borrasjosepmaria tenyearprobabilitiesofdeathduetocancerandcardiovasculardiseaseamongbreastcancerpatientsdiagnosedinnortheasternspain