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Ten-Year Probabilities of Death Due to Cancer and Cardiovascular Disease among Breast Cancer Patients Diagnosed in North-Eastern Spain
Mortality from cardiovascular disease (CVD), second tumours, and other causes is of clinical interest in the long-term follow-up of breast cancer (BC) patients. Using a cohort of BC patients (N = 6758) from the cancer registries of Girona and Tarragona (north-eastern Spain), we studied the 10-year p...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9819018/ https://www.ncbi.nlm.nih.gov/pubmed/36612726 http://dx.doi.org/10.3390/ijerph20010405 |
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author | Clèries, Ramon Ameijide, Alberto Buxó, Maria Vilardell, Mireia Martínez, José Miguel Font, Rebeca Marcos-Gragera, Rafael Puigdemont, Montse Viñas, Gemma Carulla, Marià Espinàs, Josep Alfons Galceran, Jaume Izquierdo, Ángel Borràs, Josep Maria |
author_facet | Clèries, Ramon Ameijide, Alberto Buxó, Maria Vilardell, Mireia Martínez, José Miguel Font, Rebeca Marcos-Gragera, Rafael Puigdemont, Montse Viñas, Gemma Carulla, Marià Espinàs, Josep Alfons Galceran, Jaume Izquierdo, Ángel Borràs, Josep Maria |
author_sort | Clèries, Ramon |
collection | PubMed |
description | Mortality from cardiovascular disease (CVD), second tumours, and other causes is of clinical interest in the long-term follow-up of breast cancer (BC) patients. Using a cohort of BC patients (N = 6758) from the cancer registries of Girona and Tarragona (north-eastern Spain), we studied the 10-year probabilities of death due to BC, other cancers, and CVD according to stage at diagnosis and hormone receptor (HR) status. Among the non-BC causes of death (N = 720), CVD (N = 218) surpassed other cancers (N = 196). The BC cohort presented a significantly higher risk of death due to endometrial and ovarian cancers than the general population. In Stage I, HR− patients showed a 1.72-fold higher probability of all-cause death and a 6.11-fold higher probability of breast cancer death than HR+ patients. In Stages II–III, the probability of CVD death (range 3.11% to 3.86%) surpassed that of other cancers (range 0.54% to 3.11%). In Stage IV patients, the probability of death from any cancer drove the mortality risk. Promoting screening and preventive measures in BC patients are warranted, since long-term control should encompass early detection of second neoplasms, ruling out the possibility of late recurrence. In patients diagnosed in Stages II–III at an older age, surveillance for preventing late cardiotoxicity is crucial. |
format | Online Article Text |
id | pubmed-9819018 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98190182023-01-07 Ten-Year Probabilities of Death Due to Cancer and Cardiovascular Disease among Breast Cancer Patients Diagnosed in North-Eastern Spain Clèries, Ramon Ameijide, Alberto Buxó, Maria Vilardell, Mireia Martínez, José Miguel Font, Rebeca Marcos-Gragera, Rafael Puigdemont, Montse Viñas, Gemma Carulla, Marià Espinàs, Josep Alfons Galceran, Jaume Izquierdo, Ángel Borràs, Josep Maria Int J Environ Res Public Health Article Mortality from cardiovascular disease (CVD), second tumours, and other causes is of clinical interest in the long-term follow-up of breast cancer (BC) patients. Using a cohort of BC patients (N = 6758) from the cancer registries of Girona and Tarragona (north-eastern Spain), we studied the 10-year probabilities of death due to BC, other cancers, and CVD according to stage at diagnosis and hormone receptor (HR) status. Among the non-BC causes of death (N = 720), CVD (N = 218) surpassed other cancers (N = 196). The BC cohort presented a significantly higher risk of death due to endometrial and ovarian cancers than the general population. In Stage I, HR− patients showed a 1.72-fold higher probability of all-cause death and a 6.11-fold higher probability of breast cancer death than HR+ patients. In Stages II–III, the probability of CVD death (range 3.11% to 3.86%) surpassed that of other cancers (range 0.54% to 3.11%). In Stage IV patients, the probability of death from any cancer drove the mortality risk. Promoting screening and preventive measures in BC patients are warranted, since long-term control should encompass early detection of second neoplasms, ruling out the possibility of late recurrence. In patients diagnosed in Stages II–III at an older age, surveillance for preventing late cardiotoxicity is crucial. MDPI 2022-12-27 /pmc/articles/PMC9819018/ /pubmed/36612726 http://dx.doi.org/10.3390/ijerph20010405 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Clèries, Ramon Ameijide, Alberto Buxó, Maria Vilardell, Mireia Martínez, José Miguel Font, Rebeca Marcos-Gragera, Rafael Puigdemont, Montse Viñas, Gemma Carulla, Marià Espinàs, Josep Alfons Galceran, Jaume Izquierdo, Ángel Borràs, Josep Maria Ten-Year Probabilities of Death Due to Cancer and Cardiovascular Disease among Breast Cancer Patients Diagnosed in North-Eastern Spain |
title | Ten-Year Probabilities of Death Due to Cancer and Cardiovascular Disease among Breast Cancer Patients Diagnosed in North-Eastern Spain |
title_full | Ten-Year Probabilities of Death Due to Cancer and Cardiovascular Disease among Breast Cancer Patients Diagnosed in North-Eastern Spain |
title_fullStr | Ten-Year Probabilities of Death Due to Cancer and Cardiovascular Disease among Breast Cancer Patients Diagnosed in North-Eastern Spain |
title_full_unstemmed | Ten-Year Probabilities of Death Due to Cancer and Cardiovascular Disease among Breast Cancer Patients Diagnosed in North-Eastern Spain |
title_short | Ten-Year Probabilities of Death Due to Cancer and Cardiovascular Disease among Breast Cancer Patients Diagnosed in North-Eastern Spain |
title_sort | ten-year probabilities of death due to cancer and cardiovascular disease among breast cancer patients diagnosed in north-eastern spain |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9819018/ https://www.ncbi.nlm.nih.gov/pubmed/36612726 http://dx.doi.org/10.3390/ijerph20010405 |
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