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Risk of Fractures, Repeated Fractures and Osteoporotic Fractures among Patients with Hemophilia in Taiwan: A 14-Year Population-Based Cohort Study

The world is aging, and hemophilia patients are as well. The association between patients with hemophilia (PWH) and low bone mineral density is clear. However, the incidence of fractures in patients with hemophilia is inconclusive, and no research has yet explored repeated fractures among PWH. In th...

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Autores principales: Pai, Yuan-Yi, Wang, Jiaan-Der, Ho, Hsin-En, Chou, Yi-Jung, Ho, Wen-Chao, Chan, Wei-Cheng, Chu, Wei-Min, Tsan, Yu-Tse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9819339/
https://www.ncbi.nlm.nih.gov/pubmed/36612847
http://dx.doi.org/10.3390/ijerph20010525
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author Pai, Yuan-Yi
Wang, Jiaan-Der
Ho, Hsin-En
Chou, Yi-Jung
Ho, Wen-Chao
Chan, Wei-Cheng
Chu, Wei-Min
Tsan, Yu-Tse
author_facet Pai, Yuan-Yi
Wang, Jiaan-Der
Ho, Hsin-En
Chou, Yi-Jung
Ho, Wen-Chao
Chan, Wei-Cheng
Chu, Wei-Min
Tsan, Yu-Tse
author_sort Pai, Yuan-Yi
collection PubMed
description The world is aging, and hemophilia patients are as well. The association between patients with hemophilia (PWH) and low bone mineral density is clear. However, the incidence of fractures in patients with hemophilia is inconclusive, and no research has yet explored repeated fractures among PWH. In this study, we investigated the incidence of all-site fractures, repeated fractures and osteoporotic fractures amongst PWH. The study compared the incidence of all-site fractures, repeated fractures and osteoporotic fractures occurring in all PWH who were enrolled in Taiwan’s National Health Insurance Research Database between 1997 and 2013 with an age- and gender-matched group from the general population. Eight-hundred thirty-two PWH, along with 8320 members of the general population, were included in the final analysis. After multivariate COX regression analysis with an adjustment for confounding factors, it was found that PWH experienced a higher risk of osteoporotic fracture (HR: 1.25 with 95% CI of 1.03–2.52) but only saw a neutral effect with regards to both all-sites of fracture (HR: 1.00 with 95% CI of 0.92–1.09) and repeated fractures (HR: 1.01 with 95% CI of 0.92–1.10), when compared with the general population. This 14-year population-based cohort study showed that PWH had a higher risk of osteoporotic fracture, but that hemophilia only had a neutral effect in all-sites of fracture and repeated fractures. Screening, prevention and treatment for osteoporosis and further osteoporotic fractures among PWH, in order to improve quality of life and achieve healthy aging in this particular population, remain essential.
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spelling pubmed-98193392023-01-07 Risk of Fractures, Repeated Fractures and Osteoporotic Fractures among Patients with Hemophilia in Taiwan: A 14-Year Population-Based Cohort Study Pai, Yuan-Yi Wang, Jiaan-Der Ho, Hsin-En Chou, Yi-Jung Ho, Wen-Chao Chan, Wei-Cheng Chu, Wei-Min Tsan, Yu-Tse Int J Environ Res Public Health Article The world is aging, and hemophilia patients are as well. The association between patients with hemophilia (PWH) and low bone mineral density is clear. However, the incidence of fractures in patients with hemophilia is inconclusive, and no research has yet explored repeated fractures among PWH. In this study, we investigated the incidence of all-site fractures, repeated fractures and osteoporotic fractures amongst PWH. The study compared the incidence of all-site fractures, repeated fractures and osteoporotic fractures occurring in all PWH who were enrolled in Taiwan’s National Health Insurance Research Database between 1997 and 2013 with an age- and gender-matched group from the general population. Eight-hundred thirty-two PWH, along with 8320 members of the general population, were included in the final analysis. After multivariate COX regression analysis with an adjustment for confounding factors, it was found that PWH experienced a higher risk of osteoporotic fracture (HR: 1.25 with 95% CI of 1.03–2.52) but only saw a neutral effect with regards to both all-sites of fracture (HR: 1.00 with 95% CI of 0.92–1.09) and repeated fractures (HR: 1.01 with 95% CI of 0.92–1.10), when compared with the general population. This 14-year population-based cohort study showed that PWH had a higher risk of osteoporotic fracture, but that hemophilia only had a neutral effect in all-sites of fracture and repeated fractures. Screening, prevention and treatment for osteoporosis and further osteoporotic fractures among PWH, in order to improve quality of life and achieve healthy aging in this particular population, remain essential. MDPI 2022-12-28 /pmc/articles/PMC9819339/ /pubmed/36612847 http://dx.doi.org/10.3390/ijerph20010525 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pai, Yuan-Yi
Wang, Jiaan-Der
Ho, Hsin-En
Chou, Yi-Jung
Ho, Wen-Chao
Chan, Wei-Cheng
Chu, Wei-Min
Tsan, Yu-Tse
Risk of Fractures, Repeated Fractures and Osteoporotic Fractures among Patients with Hemophilia in Taiwan: A 14-Year Population-Based Cohort Study
title Risk of Fractures, Repeated Fractures and Osteoporotic Fractures among Patients with Hemophilia in Taiwan: A 14-Year Population-Based Cohort Study
title_full Risk of Fractures, Repeated Fractures and Osteoporotic Fractures among Patients with Hemophilia in Taiwan: A 14-Year Population-Based Cohort Study
title_fullStr Risk of Fractures, Repeated Fractures and Osteoporotic Fractures among Patients with Hemophilia in Taiwan: A 14-Year Population-Based Cohort Study
title_full_unstemmed Risk of Fractures, Repeated Fractures and Osteoporotic Fractures among Patients with Hemophilia in Taiwan: A 14-Year Population-Based Cohort Study
title_short Risk of Fractures, Repeated Fractures and Osteoporotic Fractures among Patients with Hemophilia in Taiwan: A 14-Year Population-Based Cohort Study
title_sort risk of fractures, repeated fractures and osteoporotic fractures among patients with hemophilia in taiwan: a 14-year population-based cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9819339/
https://www.ncbi.nlm.nih.gov/pubmed/36612847
http://dx.doi.org/10.3390/ijerph20010525
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