Targeting Noncanonical Pyroptosis With a Small Molecular Inhibitor Alleviates Inflammation in the LPS-Induced Keratitis Mouse Model

PURPOSE: Pyroptosis, a novel proinflammatory programmed cell death, has been implicated in some ocular diseases. Of special note is the noncanonical pyroptosis that has recently been recognized to play a critical role in microbial keratitis. We previously discovered a new potent small molecular pyro...

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Detalles Bibliográficos
Autores principales: Zhang, Yun, Zhou, Nenghua, Jiao, Yan, Lin, Guifeng, Li, Xun, Gao, Sheng, Zhou, Pei, Liu, Jingming, Nan, Jinshan, Zhang, Meixia, Yang, Shengyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2023
Materias:
Physiology and Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9819737/
https://www.ncbi.nlm.nih.gov/pubmed/36595275
http://dx.doi.org/10.1167/iovs.64.1.1

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