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Underdiagnosis in Background of Emerging Public Health Challenges Related to Peri-Implant Diseases: An Interventional Split-Mouth Study

Peri-implant diseases are an emerging public health problem, and it’s considered that limitations of standard diagnostics play the role herein. The study objective was the estimation of pathological bone resorption at clinical and biological level in patients with peri-implant mucositis (PIM) and pe...

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Autores principales: Djuran, Boris, Tatic, Zoran, Perunovic, Neda, Pejcic, Natasa, Vukovic, Jovana, Petkovic-Curcin, Aleksandra, Vojvodic, Danilo, Rakic, Mia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9819861/
https://www.ncbi.nlm.nih.gov/pubmed/36612810
http://dx.doi.org/10.3390/ijerph20010477
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author Djuran, Boris
Tatic, Zoran
Perunovic, Neda
Pejcic, Natasa
Vukovic, Jovana
Petkovic-Curcin, Aleksandra
Vojvodic, Danilo
Rakic, Mia
author_facet Djuran, Boris
Tatic, Zoran
Perunovic, Neda
Pejcic, Natasa
Vukovic, Jovana
Petkovic-Curcin, Aleksandra
Vojvodic, Danilo
Rakic, Mia
author_sort Djuran, Boris
collection PubMed
description Peri-implant diseases are an emerging public health problem, and it’s considered that limitations of standard diagnostics play the role herein. The study objective was the estimation of pathological bone resorption at clinical and biological level in patients with peri-implant mucositis (PIM) and peri-implantitis (PI) before and 6 months after standard treatment and to compare them with healthy controls (HC). The split-mouth interventional study included 60 patients affected with PIM or PI. Patients that also presented at least one more HC were enrolled in the study and underwent standard non-surgical and surgical treatment, respectively. Standard clinical parameters and soluble levels of RANKL were measured in peri-implant crevicular fluid baseline and 6 months following treatment. Clinical parameters and RANKL significantly decreased following treatment in PIM and PI. However, bleeding on probing and probing depth remained significantly increased when compared to HC. RANKL answered requests for biomarker of peri-implant diseases, its baseline levels were significantly increased in PIM and PI, they decreased following treatment and reached HC in peri-implantitis, while in PIM RANKL remained significantly increased. Presence of pathological bone resorption in patients lacked its clinical signs, and respective persistence following treatment suggest the need for biomarker-supported diagnosis for timely diagnosis of peri-implantitis and appropriate orientation of respective management strategies.
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spelling pubmed-98198612023-01-07 Underdiagnosis in Background of Emerging Public Health Challenges Related to Peri-Implant Diseases: An Interventional Split-Mouth Study Djuran, Boris Tatic, Zoran Perunovic, Neda Pejcic, Natasa Vukovic, Jovana Petkovic-Curcin, Aleksandra Vojvodic, Danilo Rakic, Mia Int J Environ Res Public Health Article Peri-implant diseases are an emerging public health problem, and it’s considered that limitations of standard diagnostics play the role herein. The study objective was the estimation of pathological bone resorption at clinical and biological level in patients with peri-implant mucositis (PIM) and peri-implantitis (PI) before and 6 months after standard treatment and to compare them with healthy controls (HC). The split-mouth interventional study included 60 patients affected with PIM or PI. Patients that also presented at least one more HC were enrolled in the study and underwent standard non-surgical and surgical treatment, respectively. Standard clinical parameters and soluble levels of RANKL were measured in peri-implant crevicular fluid baseline and 6 months following treatment. Clinical parameters and RANKL significantly decreased following treatment in PIM and PI. However, bleeding on probing and probing depth remained significantly increased when compared to HC. RANKL answered requests for biomarker of peri-implant diseases, its baseline levels were significantly increased in PIM and PI, they decreased following treatment and reached HC in peri-implantitis, while in PIM RANKL remained significantly increased. Presence of pathological bone resorption in patients lacked its clinical signs, and respective persistence following treatment suggest the need for biomarker-supported diagnosis for timely diagnosis of peri-implantitis and appropriate orientation of respective management strategies. MDPI 2022-12-28 /pmc/articles/PMC9819861/ /pubmed/36612810 http://dx.doi.org/10.3390/ijerph20010477 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Djuran, Boris
Tatic, Zoran
Perunovic, Neda
Pejcic, Natasa
Vukovic, Jovana
Petkovic-Curcin, Aleksandra
Vojvodic, Danilo
Rakic, Mia
Underdiagnosis in Background of Emerging Public Health Challenges Related to Peri-Implant Diseases: An Interventional Split-Mouth Study
title Underdiagnosis in Background of Emerging Public Health Challenges Related to Peri-Implant Diseases: An Interventional Split-Mouth Study
title_full Underdiagnosis in Background of Emerging Public Health Challenges Related to Peri-Implant Diseases: An Interventional Split-Mouth Study
title_fullStr Underdiagnosis in Background of Emerging Public Health Challenges Related to Peri-Implant Diseases: An Interventional Split-Mouth Study
title_full_unstemmed Underdiagnosis in Background of Emerging Public Health Challenges Related to Peri-Implant Diseases: An Interventional Split-Mouth Study
title_short Underdiagnosis in Background of Emerging Public Health Challenges Related to Peri-Implant Diseases: An Interventional Split-Mouth Study
title_sort underdiagnosis in background of emerging public health challenges related to peri-implant diseases: an interventional split-mouth study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9819861/
https://www.ncbi.nlm.nih.gov/pubmed/36612810
http://dx.doi.org/10.3390/ijerph20010477
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