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Emerging Role of MicroRNA-30c in Neurological Disorders
MicroRNAs (miRNAs or miRs) are a class of small non-coding RNAs that negatively regulate the expression of target genes by interacting with 3′ untranslated regions of target mRNAs to induce mRNA degradation and translational repression. The miR-30 family members are involved in the development of ma...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9819962/ https://www.ncbi.nlm.nih.gov/pubmed/36613480 http://dx.doi.org/10.3390/ijms24010037 |
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author | Kumar, Manish Li, Guohong |
author_facet | Kumar, Manish Li, Guohong |
author_sort | Kumar, Manish |
collection | PubMed |
description | MicroRNAs (miRNAs or miRs) are a class of small non-coding RNAs that negatively regulate the expression of target genes by interacting with 3′ untranslated regions of target mRNAs to induce mRNA degradation and translational repression. The miR-30 family members are involved in the development of many tissues and organs and participate in the pathogenesis of human diseases. As a key member of the miR-30 family, miR-30c has been implicated in neurological disorders such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and stroke. Mechanistically, miR-30c may act as a multi-functional regulator of different pathogenic processes such as autophagy, apoptosis, endoplasmic reticulum stress, inflammation, oxidative stress, thrombosis, and neurovascular function, thereby contributing to different disease states. Here, we review and discuss the biogenesis, gene regulation, and the role and mechanisms of action of miR-30c in several neurological disorders and therapeutic potential in clinics. |
format | Online Article Text |
id | pubmed-9819962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98199622023-01-07 Emerging Role of MicroRNA-30c in Neurological Disorders Kumar, Manish Li, Guohong Int J Mol Sci Review MicroRNAs (miRNAs or miRs) are a class of small non-coding RNAs that negatively regulate the expression of target genes by interacting with 3′ untranslated regions of target mRNAs to induce mRNA degradation and translational repression. The miR-30 family members are involved in the development of many tissues and organs and participate in the pathogenesis of human diseases. As a key member of the miR-30 family, miR-30c has been implicated in neurological disorders such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and stroke. Mechanistically, miR-30c may act as a multi-functional regulator of different pathogenic processes such as autophagy, apoptosis, endoplasmic reticulum stress, inflammation, oxidative stress, thrombosis, and neurovascular function, thereby contributing to different disease states. Here, we review and discuss the biogenesis, gene regulation, and the role and mechanisms of action of miR-30c in several neurological disorders and therapeutic potential in clinics. MDPI 2022-12-20 /pmc/articles/PMC9819962/ /pubmed/36613480 http://dx.doi.org/10.3390/ijms24010037 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kumar, Manish Li, Guohong Emerging Role of MicroRNA-30c in Neurological Disorders |
title | Emerging Role of MicroRNA-30c in Neurological Disorders |
title_full | Emerging Role of MicroRNA-30c in Neurological Disorders |
title_fullStr | Emerging Role of MicroRNA-30c in Neurological Disorders |
title_full_unstemmed | Emerging Role of MicroRNA-30c in Neurological Disorders |
title_short | Emerging Role of MicroRNA-30c in Neurological Disorders |
title_sort | emerging role of microrna-30c in neurological disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9819962/ https://www.ncbi.nlm.nih.gov/pubmed/36613480 http://dx.doi.org/10.3390/ijms24010037 |
work_keys_str_mv | AT kumarmanish emergingroleofmicrorna30cinneurologicaldisorders AT liguohong emergingroleofmicrorna30cinneurologicaldisorders |