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Lung Damage in Rheumatoid Arthritis—A Retrospective Study
The current study aimed to evaluate rheumatoid arthritis (RA) patients with interstitial lung disease (ILD) in clinical practice and whether disease characteristics are associated with X-ray and high-resolution computed tomography (HR-CT) findings. Medical history of RA patients from a tertiary rheu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820047/ https://www.ncbi.nlm.nih.gov/pubmed/36613472 http://dx.doi.org/10.3390/ijms24010028 |
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author | Dinache, Georgiana Popescu, Claudiu Costinel Mogoșan, Corina Enache, Luminita Agache, Mihaela Codreanu, Cătălin |
author_facet | Dinache, Georgiana Popescu, Claudiu Costinel Mogoșan, Corina Enache, Luminita Agache, Mihaela Codreanu, Cătălin |
author_sort | Dinache, Georgiana |
collection | PubMed |
description | The current study aimed to evaluate rheumatoid arthritis (RA) patients with interstitial lung disease (ILD) in clinical practice and whether disease characteristics are associated with X-ray and high-resolution computed tomography (HR-CT) findings. Medical history of RA patients from a tertiary rheumatology clinic was retrieved from its electronic database starting from 1 January 2019 until the study date (8 August 2022) using International Classification of Disease version 10 codes for RA, ILD and exclusion criteria. The study included 78 RA patients (75.6% women, 15.4% active smokers), with average time from RA to ILD of 5.6 years. Regarding chest X-ray findings, men had a higher prevalence of nodules, combined fibrosis and nodules and combined bronchiectasis and nodules, rheumatoid factor (RF)-positive patients had a higher prevalence of fibrosis and anti-cyclic citrullinated peptide antibodies (ACPA)-positive patients had a higher prevalence of bronchiectasis. Regarding HR-CT findings, patients actively treated with methotrexate had a higher prevalence of nodules; a combination of fibrosis and nodules; combination of emphysema and nodules; and combination of fibrosis, emphysema and nodules. ILD develops within approximately 5 years from RA diagnosis, and ILD-associated imaging findings on chest X-rays and HR-CT are more prevalent among men with RA, among patients with positive RA serology (RF and/or ACPA) and RA patients on methotrexate. |
format | Online Article Text |
id | pubmed-9820047 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98200472023-01-07 Lung Damage in Rheumatoid Arthritis—A Retrospective Study Dinache, Georgiana Popescu, Claudiu Costinel Mogoșan, Corina Enache, Luminita Agache, Mihaela Codreanu, Cătălin Int J Mol Sci Article The current study aimed to evaluate rheumatoid arthritis (RA) patients with interstitial lung disease (ILD) in clinical practice and whether disease characteristics are associated with X-ray and high-resolution computed tomography (HR-CT) findings. Medical history of RA patients from a tertiary rheumatology clinic was retrieved from its electronic database starting from 1 January 2019 until the study date (8 August 2022) using International Classification of Disease version 10 codes for RA, ILD and exclusion criteria. The study included 78 RA patients (75.6% women, 15.4% active smokers), with average time from RA to ILD of 5.6 years. Regarding chest X-ray findings, men had a higher prevalence of nodules, combined fibrosis and nodules and combined bronchiectasis and nodules, rheumatoid factor (RF)-positive patients had a higher prevalence of fibrosis and anti-cyclic citrullinated peptide antibodies (ACPA)-positive patients had a higher prevalence of bronchiectasis. Regarding HR-CT findings, patients actively treated with methotrexate had a higher prevalence of nodules; a combination of fibrosis and nodules; combination of emphysema and nodules; and combination of fibrosis, emphysema and nodules. ILD develops within approximately 5 years from RA diagnosis, and ILD-associated imaging findings on chest X-rays and HR-CT are more prevalent among men with RA, among patients with positive RA serology (RF and/or ACPA) and RA patients on methotrexate. MDPI 2022-12-20 /pmc/articles/PMC9820047/ /pubmed/36613472 http://dx.doi.org/10.3390/ijms24010028 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Dinache, Georgiana Popescu, Claudiu Costinel Mogoșan, Corina Enache, Luminita Agache, Mihaela Codreanu, Cătălin Lung Damage in Rheumatoid Arthritis—A Retrospective Study |
title | Lung Damage in Rheumatoid Arthritis—A Retrospective Study |
title_full | Lung Damage in Rheumatoid Arthritis—A Retrospective Study |
title_fullStr | Lung Damage in Rheumatoid Arthritis—A Retrospective Study |
title_full_unstemmed | Lung Damage in Rheumatoid Arthritis—A Retrospective Study |
title_short | Lung Damage in Rheumatoid Arthritis—A Retrospective Study |
title_sort | lung damage in rheumatoid arthritis—a retrospective study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820047/ https://www.ncbi.nlm.nih.gov/pubmed/36613472 http://dx.doi.org/10.3390/ijms24010028 |
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