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Lung Damage in Rheumatoid Arthritis—A Retrospective Study

The current study aimed to evaluate rheumatoid arthritis (RA) patients with interstitial lung disease (ILD) in clinical practice and whether disease characteristics are associated with X-ray and high-resolution computed tomography (HR-CT) findings. Medical history of RA patients from a tertiary rheu...

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Autores principales: Dinache, Georgiana, Popescu, Claudiu Costinel, Mogoșan, Corina, Enache, Luminita, Agache, Mihaela, Codreanu, Cătălin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820047/
https://www.ncbi.nlm.nih.gov/pubmed/36613472
http://dx.doi.org/10.3390/ijms24010028
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author Dinache, Georgiana
Popescu, Claudiu Costinel
Mogoșan, Corina
Enache, Luminita
Agache, Mihaela
Codreanu, Cătălin
author_facet Dinache, Georgiana
Popescu, Claudiu Costinel
Mogoșan, Corina
Enache, Luminita
Agache, Mihaela
Codreanu, Cătălin
author_sort Dinache, Georgiana
collection PubMed
description The current study aimed to evaluate rheumatoid arthritis (RA) patients with interstitial lung disease (ILD) in clinical practice and whether disease characteristics are associated with X-ray and high-resolution computed tomography (HR-CT) findings. Medical history of RA patients from a tertiary rheumatology clinic was retrieved from its electronic database starting from 1 January 2019 until the study date (8 August 2022) using International Classification of Disease version 10 codes for RA, ILD and exclusion criteria. The study included 78 RA patients (75.6% women, 15.4% active smokers), with average time from RA to ILD of 5.6 years. Regarding chest X-ray findings, men had a higher prevalence of nodules, combined fibrosis and nodules and combined bronchiectasis and nodules, rheumatoid factor (RF)-positive patients had a higher prevalence of fibrosis and anti-cyclic citrullinated peptide antibodies (ACPA)-positive patients had a higher prevalence of bronchiectasis. Regarding HR-CT findings, patients actively treated with methotrexate had a higher prevalence of nodules; a combination of fibrosis and nodules; combination of emphysema and nodules; and combination of fibrosis, emphysema and nodules. ILD develops within approximately 5 years from RA diagnosis, and ILD-associated imaging findings on chest X-rays and HR-CT are more prevalent among men with RA, among patients with positive RA serology (RF and/or ACPA) and RA patients on methotrexate.
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spelling pubmed-98200472023-01-07 Lung Damage in Rheumatoid Arthritis—A Retrospective Study Dinache, Georgiana Popescu, Claudiu Costinel Mogoșan, Corina Enache, Luminita Agache, Mihaela Codreanu, Cătălin Int J Mol Sci Article The current study aimed to evaluate rheumatoid arthritis (RA) patients with interstitial lung disease (ILD) in clinical practice and whether disease characteristics are associated with X-ray and high-resolution computed tomography (HR-CT) findings. Medical history of RA patients from a tertiary rheumatology clinic was retrieved from its electronic database starting from 1 January 2019 until the study date (8 August 2022) using International Classification of Disease version 10 codes for RA, ILD and exclusion criteria. The study included 78 RA patients (75.6% women, 15.4% active smokers), with average time from RA to ILD of 5.6 years. Regarding chest X-ray findings, men had a higher prevalence of nodules, combined fibrosis and nodules and combined bronchiectasis and nodules, rheumatoid factor (RF)-positive patients had a higher prevalence of fibrosis and anti-cyclic citrullinated peptide antibodies (ACPA)-positive patients had a higher prevalence of bronchiectasis. Regarding HR-CT findings, patients actively treated with methotrexate had a higher prevalence of nodules; a combination of fibrosis and nodules; combination of emphysema and nodules; and combination of fibrosis, emphysema and nodules. ILD develops within approximately 5 years from RA diagnosis, and ILD-associated imaging findings on chest X-rays and HR-CT are more prevalent among men with RA, among patients with positive RA serology (RF and/or ACPA) and RA patients on methotrexate. MDPI 2022-12-20 /pmc/articles/PMC9820047/ /pubmed/36613472 http://dx.doi.org/10.3390/ijms24010028 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dinache, Georgiana
Popescu, Claudiu Costinel
Mogoșan, Corina
Enache, Luminita
Agache, Mihaela
Codreanu, Cătălin
Lung Damage in Rheumatoid Arthritis—A Retrospective Study
title Lung Damage in Rheumatoid Arthritis—A Retrospective Study
title_full Lung Damage in Rheumatoid Arthritis—A Retrospective Study
title_fullStr Lung Damage in Rheumatoid Arthritis—A Retrospective Study
title_full_unstemmed Lung Damage in Rheumatoid Arthritis—A Retrospective Study
title_short Lung Damage in Rheumatoid Arthritis—A Retrospective Study
title_sort lung damage in rheumatoid arthritis—a retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820047/
https://www.ncbi.nlm.nih.gov/pubmed/36613472
http://dx.doi.org/10.3390/ijms24010028
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