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Circulating MicroRNAs and Extracellular Vesicle-Derived MicroRNAs as Predictors of Functional Recovery in Ischemic Stroke Patients: A Systematic Review and Meta-Analysis

Stroke accounts for the second leading cause of death and a major cause of disability, with limited therapeutic strategy in both the acute and chronic phases. Blood-based biomarkers are intensively researched and widely recognized as useful tools to predict the prognoses of patients confronted with...

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Autores principales: Burlacu, Codrin-Constantin, Ciobanu, Daniela, Badulescu, Andrei-Vlad, Chelaru, Vlad-Florin, Mitre, Andrei-Otto, Capitanescu, Bogdan, Hermann, Dirk M., Popa-Wagner, Aurel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820088/
https://www.ncbi.nlm.nih.gov/pubmed/36613694
http://dx.doi.org/10.3390/ijms24010251
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author Burlacu, Codrin-Constantin
Ciobanu, Daniela
Badulescu, Andrei-Vlad
Chelaru, Vlad-Florin
Mitre, Andrei-Otto
Capitanescu, Bogdan
Hermann, Dirk M.
Popa-Wagner, Aurel
author_facet Burlacu, Codrin-Constantin
Ciobanu, Daniela
Badulescu, Andrei-Vlad
Chelaru, Vlad-Florin
Mitre, Andrei-Otto
Capitanescu, Bogdan
Hermann, Dirk M.
Popa-Wagner, Aurel
author_sort Burlacu, Codrin-Constantin
collection PubMed
description Stroke accounts for the second leading cause of death and a major cause of disability, with limited therapeutic strategy in both the acute and chronic phases. Blood-based biomarkers are intensively researched and widely recognized as useful tools to predict the prognoses of patients confronted with therapeutically limited diseases. We performed a systematic review of the circulating biomarkers in IS patients with prognostic value, with a focus on microRNAs and exosomes as predictive biomarkers of motor and cognitive recovery. We identified 63 studies, totalizing 72 circulating biomarkers with prognostic value in stroke recovery, as follows: 68 miRNAs and exosomal-miRNAs being identified as predictive for motor recovery after stroke, and seven biomarkers being predictive for cognitive recovery. Twelve meta-analyses were performed using effect sizes (random-effects and fixed-effects model). The most significant correlation findings obtained after pooling were with miR-21, miR-29b, miR-125b-5p, miR-126, and miR-335. We identified several miRNAs that were correlated with clinical outcomes of stroke severity and recovery after ischemic stroke, providing predictive information on motor and cognitive recovery. Based on the current state of research, we identified serum miR-9 and neutrophil miR-29b as the most promising biomarkers for in-depth follow-up studies, followed by serum miR-124 and plasma miR-125b.
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spelling pubmed-98200882023-01-07 Circulating MicroRNAs and Extracellular Vesicle-Derived MicroRNAs as Predictors of Functional Recovery in Ischemic Stroke Patients: A Systematic Review and Meta-Analysis Burlacu, Codrin-Constantin Ciobanu, Daniela Badulescu, Andrei-Vlad Chelaru, Vlad-Florin Mitre, Andrei-Otto Capitanescu, Bogdan Hermann, Dirk M. Popa-Wagner, Aurel Int J Mol Sci Review Stroke accounts for the second leading cause of death and a major cause of disability, with limited therapeutic strategy in both the acute and chronic phases. Blood-based biomarkers are intensively researched and widely recognized as useful tools to predict the prognoses of patients confronted with therapeutically limited diseases. We performed a systematic review of the circulating biomarkers in IS patients with prognostic value, with a focus on microRNAs and exosomes as predictive biomarkers of motor and cognitive recovery. We identified 63 studies, totalizing 72 circulating biomarkers with prognostic value in stroke recovery, as follows: 68 miRNAs and exosomal-miRNAs being identified as predictive for motor recovery after stroke, and seven biomarkers being predictive for cognitive recovery. Twelve meta-analyses were performed using effect sizes (random-effects and fixed-effects model). The most significant correlation findings obtained after pooling were with miR-21, miR-29b, miR-125b-5p, miR-126, and miR-335. We identified several miRNAs that were correlated with clinical outcomes of stroke severity and recovery after ischemic stroke, providing predictive information on motor and cognitive recovery. Based on the current state of research, we identified serum miR-9 and neutrophil miR-29b as the most promising biomarkers for in-depth follow-up studies, followed by serum miR-124 and plasma miR-125b. MDPI 2022-12-23 /pmc/articles/PMC9820088/ /pubmed/36613694 http://dx.doi.org/10.3390/ijms24010251 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Burlacu, Codrin-Constantin
Ciobanu, Daniela
Badulescu, Andrei-Vlad
Chelaru, Vlad-Florin
Mitre, Andrei-Otto
Capitanescu, Bogdan
Hermann, Dirk M.
Popa-Wagner, Aurel
Circulating MicroRNAs and Extracellular Vesicle-Derived MicroRNAs as Predictors of Functional Recovery in Ischemic Stroke Patients: A Systematic Review and Meta-Analysis
title Circulating MicroRNAs and Extracellular Vesicle-Derived MicroRNAs as Predictors of Functional Recovery in Ischemic Stroke Patients: A Systematic Review and Meta-Analysis
title_full Circulating MicroRNAs and Extracellular Vesicle-Derived MicroRNAs as Predictors of Functional Recovery in Ischemic Stroke Patients: A Systematic Review and Meta-Analysis
title_fullStr Circulating MicroRNAs and Extracellular Vesicle-Derived MicroRNAs as Predictors of Functional Recovery in Ischemic Stroke Patients: A Systematic Review and Meta-Analysis
title_full_unstemmed Circulating MicroRNAs and Extracellular Vesicle-Derived MicroRNAs as Predictors of Functional Recovery in Ischemic Stroke Patients: A Systematic Review and Meta-Analysis
title_short Circulating MicroRNAs and Extracellular Vesicle-Derived MicroRNAs as Predictors of Functional Recovery in Ischemic Stroke Patients: A Systematic Review and Meta-Analysis
title_sort circulating micrornas and extracellular vesicle-derived micrornas as predictors of functional recovery in ischemic stroke patients: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820088/
https://www.ncbi.nlm.nih.gov/pubmed/36613694
http://dx.doi.org/10.3390/ijms24010251
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