The Role of Deubiquitinating Enzyme in Head and Neck Squamous Cell Carcinoma

Ubiquitination and deubiquitination are two popular ways for the post-translational modification of proteins. These two modifications affect intracellular localization, stability, and function of target proteins. The process of deubiquitination is involved in histone modification, cell cycle regulat...

Descripción completa

Detalles Bibliográficos
Autores principales: Jin, Shengjian, Kudo, Yasusei, Horiguchi, Taigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820089/
https://www.ncbi.nlm.nih.gov/pubmed/36613989
http://dx.doi.org/10.3390/ijms24010552
_version_ 1784865385276768256
author Jin, Shengjian
Kudo, Yasusei
Horiguchi, Taigo
author_facet Jin, Shengjian
Kudo, Yasusei
Horiguchi, Taigo
author_sort Jin, Shengjian
collection PubMed
description Ubiquitination and deubiquitination are two popular ways for the post-translational modification of proteins. These two modifications affect intracellular localization, stability, and function of target proteins. The process of deubiquitination is involved in histone modification, cell cycle regulation, cell differentiation, apoptosis, endocytosis, autophagy, and DNA repair after damage. Moreover, it is involved in the processes of carcinogenesis and cancer development. In this review, we discuss these issues in understanding deubiquitinating enzyme (DUB) function in head and neck squamous cell carcinoma (HNSCC), and their potential therapeutic strategies for HNSCC patients are also discussed.
format Online
Article
Text
id pubmed-9820089
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98200892023-01-07 The Role of Deubiquitinating Enzyme in Head and Neck Squamous Cell Carcinoma Jin, Shengjian Kudo, Yasusei Horiguchi, Taigo Int J Mol Sci Review Ubiquitination and deubiquitination are two popular ways for the post-translational modification of proteins. These two modifications affect intracellular localization, stability, and function of target proteins. The process of deubiquitination is involved in histone modification, cell cycle regulation, cell differentiation, apoptosis, endocytosis, autophagy, and DNA repair after damage. Moreover, it is involved in the processes of carcinogenesis and cancer development. In this review, we discuss these issues in understanding deubiquitinating enzyme (DUB) function in head and neck squamous cell carcinoma (HNSCC), and their potential therapeutic strategies for HNSCC patients are also discussed. MDPI 2022-12-29 /pmc/articles/PMC9820089/ /pubmed/36613989 http://dx.doi.org/10.3390/ijms24010552 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jin, Shengjian
Kudo, Yasusei
Horiguchi, Taigo
The Role of Deubiquitinating Enzyme in Head and Neck Squamous Cell Carcinoma
title The Role of Deubiquitinating Enzyme in Head and Neck Squamous Cell Carcinoma
title_full The Role of Deubiquitinating Enzyme in Head and Neck Squamous Cell Carcinoma
title_fullStr The Role of Deubiquitinating Enzyme in Head and Neck Squamous Cell Carcinoma
title_full_unstemmed The Role of Deubiquitinating Enzyme in Head and Neck Squamous Cell Carcinoma
title_short The Role of Deubiquitinating Enzyme in Head and Neck Squamous Cell Carcinoma
title_sort role of deubiquitinating enzyme in head and neck squamous cell carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820089/
https://www.ncbi.nlm.nih.gov/pubmed/36613989
http://dx.doi.org/10.3390/ijms24010552
work_keys_str_mv AT jinshengjian theroleofdeubiquitinatingenzymeinheadandnecksquamouscellcarcinoma
AT kudoyasusei theroleofdeubiquitinatingenzymeinheadandnecksquamouscellcarcinoma
AT horiguchitaigo theroleofdeubiquitinatingenzymeinheadandnecksquamouscellcarcinoma
AT jinshengjian roleofdeubiquitinatingenzymeinheadandnecksquamouscellcarcinoma
AT kudoyasusei roleofdeubiquitinatingenzymeinheadandnecksquamouscellcarcinoma
AT horiguchitaigo roleofdeubiquitinatingenzymeinheadandnecksquamouscellcarcinoma

Ejemplares similares