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Prevalence and Associated Factors of Post-COVID-19 Syndrome in a Brazilian Cohort after 3 and 6 Months of Hospital Discharge

(1) Objectives: To evaluate the frequency and factors associated with the Post-COVID-19 Syndrome (PCS) in COVID-19 survivors after 3 and 6 months of hospital discharge; (2) Methods: We conducted a cohort study with patients who were hospitalized with COVID-19 in a referral public hospital in Brasíli...

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Autores principales: Lapa, Juliana, Rosa, Davi, Mendes, João Pedro Lima, Deusdará, Rodolfo, Romero, Gustavo Adolfo Sierra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820092/
https://www.ncbi.nlm.nih.gov/pubmed/36613170
http://dx.doi.org/10.3390/ijerph20010848
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author Lapa, Juliana
Rosa, Davi
Mendes, João Pedro Lima
Deusdará, Rodolfo
Romero, Gustavo Adolfo Sierra
author_facet Lapa, Juliana
Rosa, Davi
Mendes, João Pedro Lima
Deusdará, Rodolfo
Romero, Gustavo Adolfo Sierra
author_sort Lapa, Juliana
collection PubMed
description (1) Objectives: To evaluate the frequency and factors associated with the Post-COVID-19 Syndrome (PCS) in COVID-19 survivors after 3 and 6 months of hospital discharge; (2) Methods: We conducted a cohort study with patients who were hospitalized with COVID-19 in a referral public hospital in Brasília, Federal District, Brazil. After 3 and 6 months of discharge, patients answered a questionnaire about PCS symptoms. Poisson regression with robust variance was used to estimate the crude and adjusted prevalence ratios (PR and aPR) of PCS. (3) Results: The prevalence of PCS was 81% and 61% after 3 and 6 months of hospital discharge, respectively. The main symptoms after 3 months of discharge were hair loss (44%), fatigue (42%), and memory loss (39%); while after 6 months, they were memory loss (29%) and fatigue (27%). In the multivariate analysis, the main factor associated with PCS was female gender (aPR): 1.28 (1.16–1.41) and 1.60 (1.34–1.90), 3 and 6 months after hospital discharge, respectively. Hypercholesterolemia was also associated with PCS after 3 months aPR of 1.15 (1.04–1.27). After 6 months of discharge, obesity [aPR: 1.22 (1.03–1.45)] and pronation [aPR: 1.15 (1.06–1.25)] were relevant associated factors. (4) Conclusions: The prevalence of PCS was high in COVID-19 survivors who had the moderate and severe forms of the disease. Memory loss was the most persistent symptom. Our data pointed to female gender, hypercholesterolemia, obesity, and pronation during hospitalization as relevant PCS-associated risk factors.
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spelling pubmed-98200922023-01-07 Prevalence and Associated Factors of Post-COVID-19 Syndrome in a Brazilian Cohort after 3 and 6 Months of Hospital Discharge Lapa, Juliana Rosa, Davi Mendes, João Pedro Lima Deusdará, Rodolfo Romero, Gustavo Adolfo Sierra Int J Environ Res Public Health Article (1) Objectives: To evaluate the frequency and factors associated with the Post-COVID-19 Syndrome (PCS) in COVID-19 survivors after 3 and 6 months of hospital discharge; (2) Methods: We conducted a cohort study with patients who were hospitalized with COVID-19 in a referral public hospital in Brasília, Federal District, Brazil. After 3 and 6 months of discharge, patients answered a questionnaire about PCS symptoms. Poisson regression with robust variance was used to estimate the crude and adjusted prevalence ratios (PR and aPR) of PCS. (3) Results: The prevalence of PCS was 81% and 61% after 3 and 6 months of hospital discharge, respectively. The main symptoms after 3 months of discharge were hair loss (44%), fatigue (42%), and memory loss (39%); while after 6 months, they were memory loss (29%) and fatigue (27%). In the multivariate analysis, the main factor associated with PCS was female gender (aPR): 1.28 (1.16–1.41) and 1.60 (1.34–1.90), 3 and 6 months after hospital discharge, respectively. Hypercholesterolemia was also associated with PCS after 3 months aPR of 1.15 (1.04–1.27). After 6 months of discharge, obesity [aPR: 1.22 (1.03–1.45)] and pronation [aPR: 1.15 (1.06–1.25)] were relevant associated factors. (4) Conclusions: The prevalence of PCS was high in COVID-19 survivors who had the moderate and severe forms of the disease. Memory loss was the most persistent symptom. Our data pointed to female gender, hypercholesterolemia, obesity, and pronation during hospitalization as relevant PCS-associated risk factors. MDPI 2023-01-02 /pmc/articles/PMC9820092/ /pubmed/36613170 http://dx.doi.org/10.3390/ijerph20010848 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lapa, Juliana
Rosa, Davi
Mendes, João Pedro Lima
Deusdará, Rodolfo
Romero, Gustavo Adolfo Sierra
Prevalence and Associated Factors of Post-COVID-19 Syndrome in a Brazilian Cohort after 3 and 6 Months of Hospital Discharge
title Prevalence and Associated Factors of Post-COVID-19 Syndrome in a Brazilian Cohort after 3 and 6 Months of Hospital Discharge
title_full Prevalence and Associated Factors of Post-COVID-19 Syndrome in a Brazilian Cohort after 3 and 6 Months of Hospital Discharge
title_fullStr Prevalence and Associated Factors of Post-COVID-19 Syndrome in a Brazilian Cohort after 3 and 6 Months of Hospital Discharge
title_full_unstemmed Prevalence and Associated Factors of Post-COVID-19 Syndrome in a Brazilian Cohort after 3 and 6 Months of Hospital Discharge
title_short Prevalence and Associated Factors of Post-COVID-19 Syndrome in a Brazilian Cohort after 3 and 6 Months of Hospital Discharge
title_sort prevalence and associated factors of post-covid-19 syndrome in a brazilian cohort after 3 and 6 months of hospital discharge
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820092/
https://www.ncbi.nlm.nih.gov/pubmed/36613170
http://dx.doi.org/10.3390/ijerph20010848
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