Cargando…

Skin-Derived ABCB5(+) Mesenchymal Stem Cells for High-Medical-Need Inflammatory Diseases: From Discovery to Entering Clinical Routine

The ATP-binding cassette superfamily member ABCB5 identifies a subset of skin-resident mesenchymal stem cells (MSCs) that exhibit potent immunomodulatory and wound healing-promoting capacities along with superior homing ability. The ABCB5(+) MSCs can be easily accessed from discarded skin samples, e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Niebergall-Roth, Elke, Frank, Natasha Y., Ganss, Christoph, Frank, Markus H., Kluth, Mark A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820160/ https://www.ncbi.nlm.nih.gov/pubmed/36613507 http://dx.doi.org/10.3390/ijms24010066

Ejemplares similares

Kinetics of Wound Development and Healing Suggests a Skin-Stabilizing Effect of Allogeneic ABCB5(+) Mesenchymal Stromal Cell Treatment in Recessive Dystrophic Epidermolysis Bullosa
por: Niebergall-Roth, Elke, et al.
Publicado: (2023)

Corrigendum to ABCB5+ mesenchymal stromal cells facilitate complete and durable wound closure in recessive dystrophic epidermolysis bullosa [Cytotherapy 25 (2023) 782–788/1562]
por: Dieter, Kathrin, et al.
Publicado: (2023)

In vivo safety profile and biodistribution of GMP-manufactured human skin-derived ABCB5-positive mesenchymal stromal cells for use in clinical trials
por: TAPPENBECK, NILS, et al.
Publicado: (2019)

Process data of allogeneic ex vivo-expanded ABCB5(+) mesenchymal stromal cells for human use: off-the-shelf GMP-manufactured donor-independent ATMP
por: Ballikaya, Seda, et al.
Publicado: (2020)

Clinical trial of ABCB5(+) mesenchymal stem cells for recessive dystrophic epidermolysis bullosa
por: Kiritsi, Dimitra, et al.
Publicado: (2021)

Translational development of ABCB5(+) dermal mesenchymal stem cells for therapeutic induction of angiogenesis in non-healing diabetic foot ulcers
por: Kerstan, Andreas, et al.
Publicado: (2022)

Drug Regulatory-Compliant Validation of a qPCR Assay for Bioanalysis Studies of a Cell Therapy Product with a Special Focus on Matrix Interferences in a Wide Range of Organ Tissues
por: Schröder, Hannes M., et al.
Publicado: (2023)

ABCB5(+) mesenchymal stromal cells therapy protects from hypoxia by restoring Ca(2+) homeostasis in vitro and in vivo
por: Yan, Kaixuan, et al.
Publicado: (2023)

ABCB5+ Limbal Epithelial Stem Cells Inhibit Developmental but Promote Inflammatory (Lymph) Angiogenesis While Preventing Corneal Inflammation
por: Meshko, Berbang, et al.
Publicado: (2023)

Process development and safety evaluation of ABCB5(+) limbal stem cells as advanced-therapy medicinal product to treat limbal stem cell deficiency
por: Norrick, Alexandra, et al.
Publicado: (2021)

Allogeneic ABCB5(+) Mesenchymal Stem Cells for Treatment-Refractory Chronic Venous Ulcers: A Phase I/IIa Clinical Trial
por: Kerstan, Andreas, et al.
Publicado: (2021)

Ex vivo-expanded highly pure ABCB5(+) mesenchymal stromal cells as Good Manufacturing Practice-compliant autologous advanced therapy medicinal product for clinical use: process validation and first in-human data
por: Kerstan, Andreas, et al.
Publicado: (2020)

Consecutive dosing of UVB irradiation induces loss of ABCB5 expression and activation of EMT and fibrosis proteins in limbal epithelial cells similar to pterygium epithelium
por: Domdey, M., et al.
Publicado: (2022)

Suppression of Neutrophil-Mediated Tissue Damage—A Novel Skill of Mesenchymal Stem Cells
por: Jiang, Dongsheng, et al.
Publicado: (2016)

ABCB1 in dermatology: roles in skin diseases and their treatment
por: Weng, H. J., et al.
Publicado: (2021)

Rapid generation of Col7a1(−/−) mouse model of recessive dystrophic epidermolysis bullosa and partial rescue via immunosuppressive dermal mesenchymal stem cells
por: Webber, Beau R., et al.
Publicado: (2017)

Detergent Screening and Purification of the Human Liver ABC Transporters BSEP (ABCB11) and MDR3 (ABCB4) Expressed in the Yeast Pichia pastoris
por: Ellinger, Philipp, et al.
Publicado: (2013)

A transportome-scale amiRNA-based screen identifies redundant roles of Arabidopsis ABCB6 and ABCB20 in auxin transport
por: Zhang, Yuqin, et al.
Publicado: (2018)

ABCB1 polymorphism predicts escitalopram dose needed for remission in major depression
por: Singh, A B, et al.
Publicado: (2012)

Should Asian inflammatory bowel disease patients need routine thromboprophylaxis?
por: Weng, Meng-Tzu, et al.
Publicado: (2018)

In vitro and in vivo identification of ABCB1 as an efflux transporter of bosutinib
por: Redaelli, Sara, et al.
Publicado: (2015)

Vitamin D modulates biliary fibrosis in ABCB4-deficient mice
por: Hochrath, Katrin, et al.
Publicado: (2014)

Genetics of ABCB1 in Cancer
por: Skinner, Katie T., et al.
Publicado: (2023)

Upregulation of cellular glutathione levels in human ABCB5- and murine Abcb5-transfected cells
por: Kondo, Shingo, et al.
Publicado: (2015)

Influence of the Bile Acid Transporter Genes ABCB4, ABCB8, and ABCB11 and the Farnesoid X Receptor on the Response to Ursodeoxycholic Acid in Patients with Nonalcoholic Steatohepatitis
por: Kreimeyer, Henriette, et al.
Publicado: (2023)

A novel spheroid-based co-culture model mimics loss of keratinocyte differentiation, melanoma cell invasion, and drug-induced selection of ABCB5-expressing cells
por: Klicks, Julia, et al.
Publicado: (2019)

Phenotypic spectrum and diagnostic pitfalls of ABCB4 deficiency depending on age of onset
por: Schatz, Stephanie Barbara, et al.
Publicado: (2018)

IL-13 as Target to Reduce Cholestasis and Dysbiosis in Abcb4 Knockout Mice
por: Hahn, Luisa, et al.
Publicado: (2020)

Plant Lessons: Exploring ABCB Functionality Through Structural Modeling
por: Bailly, Aurélien, et al.
Publicado: (2012)

Machine learning: from radiomics to discovery and routine
por: Langs, G., et al.
Publicado: (2018)

Basic Erosive Wear Examination (BEWE): a new scoring system for scientific and clinical needs
por: Bartlett, D., et al.
Publicado: (2008)

A frequent variant in the human bile salt export pump gene ABCB11 is associated with hepatitis C virus infection, but not liver stiffness in a German population
por: Müllenbach, Roman, et al.
Publicado: (2012)

Teaching an old dog new tricks: reactivated developmental signaling pathways regulate ABCB1 and chemoresistance in cancer
por: Lee, Wing-Kee, et al.
Publicado: (2021)

Pharmacologic Antagonization of Cannabinoid Receptor 1 Improves Cholestasis in Abcb4(-/-) Mice
por: Helmrich, Nora, et al.
Publicado: (2021)

Abcb1a and Abcb1b genes function differentially in blood–testis barrier dynamics in the rat
por: Su, Linlin, et al.
Publicado: (2017)

UV light-blocking contact lenses protect against short-term UVB-induced limbal stem cell niche damage and inflammation
por: Notara, M., et al.
Publicado: (2018)

Activated Eosinophils in Association with Enteric Nerves in Inflammatory Bowel Disease
por: Smyth, Claire M., et al.
Publicado: (2013)

Comment on: Routine practice needs shifting from linear to purse-string skin closure in closure of stoma sites
por: Neumann, Philipp-Alexander, et al.
Publicado: (2020)

Exploring Natural Product Activity and Species Source Candidates for Hunting ABCB1 Transporter Inhibitors: An In Silico Drug Discovery Study
por: Ibrahim, Mahmoud A. A., et al.
Publicado: (2022)

Role of Transferrin Receptor and the ABC Transporters ABCB6 and ABCB7 for Resistance and Differentiation of Tumor Cells towards Artesunate
por: Kelter, Gerhard, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_7skmo51j8vq400kct2bqip9ddu