Design and Synthesis of Conformationally Flexible Scaffold as Bitopic Ligands for Potent D(3)-Selective Antagonists

Previous studies have confirmed that the binding of D(3) receptor antagonists is competitively inhibited by endogenous dopamine despite excellent binding affinity for D(3) receptors. This result urges the development of an alternative scaffold that is capable of competing with dopamine for binding t...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Ho Young, Lee, Ji Youn, Hsieh, Chia-Ju, Taylor, Michelle, Luedtke, Robert R., Mach, Robert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820167/
https://www.ncbi.nlm.nih.gov/pubmed/36613875
http://dx.doi.org/10.3390/ijms24010432

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820167/
https://www.ncbi.nlm.nih.gov/pubmed/36613875
http://dx.doi.org/10.3390/ijms24010432

Ejemplares similares