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Galectin-2 in Health and Diseases

Galectin-2 is a prototype member of the galactoside-binding galectin family. It is predominately expressed in the gastrointestinal tract but is also detected in several other tissues such as the placenta and in the cardiovascular system. Galectin-2 expression and secretion by epithelial cells has be...

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Detalles Bibliográficos
Autores principales: Negedu, Muhammed N., Duckworth, Carrie A., Yu, Lu-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820181/
https://www.ncbi.nlm.nih.gov/pubmed/36613785
http://dx.doi.org/10.3390/ijms24010341
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author Negedu, Muhammed N.
Duckworth, Carrie A.
Yu, Lu-Gang
author_facet Negedu, Muhammed N.
Duckworth, Carrie A.
Yu, Lu-Gang
author_sort Negedu, Muhammed N.
collection PubMed
description Galectin-2 is a prototype member of the galactoside-binding galectin family. It is predominately expressed in the gastrointestinal tract but is also detected in several other tissues such as the placenta and in the cardiovascular system. Galectin-2 expression and secretion by epithelial cells has been reported to contribute to the strength of the mucus layer, protect the integrity of epithelia. A number of studies have also suggested the involvement of galectin-2 in tissue inflammation, immune response and cell apoptosis. Alteration of galectin-2 expression occurs in inflammatory bowel disease, coronary artery diseases, rheumatoid arthritis, cancer, and pregnancy disorders and has been shown to be involved in disease pathogenesis. This review discusses our current understanding of the role and actions of galectin-2 in regulation of these pathophysiological conditions.
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spelling pubmed-98201812023-01-07 Galectin-2 in Health and Diseases Negedu, Muhammed N. Duckworth, Carrie A. Yu, Lu-Gang Int J Mol Sci Review Galectin-2 is a prototype member of the galactoside-binding galectin family. It is predominately expressed in the gastrointestinal tract but is also detected in several other tissues such as the placenta and in the cardiovascular system. Galectin-2 expression and secretion by epithelial cells has been reported to contribute to the strength of the mucus layer, protect the integrity of epithelia. A number of studies have also suggested the involvement of galectin-2 in tissue inflammation, immune response and cell apoptosis. Alteration of galectin-2 expression occurs in inflammatory bowel disease, coronary artery diseases, rheumatoid arthritis, cancer, and pregnancy disorders and has been shown to be involved in disease pathogenesis. This review discusses our current understanding of the role and actions of galectin-2 in regulation of these pathophysiological conditions. MDPI 2022-12-25 /pmc/articles/PMC9820181/ /pubmed/36613785 http://dx.doi.org/10.3390/ijms24010341 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Negedu, Muhammed N.
Duckworth, Carrie A.
Yu, Lu-Gang
Galectin-2 in Health and Diseases
title Galectin-2 in Health and Diseases
title_full Galectin-2 in Health and Diseases
title_fullStr Galectin-2 in Health and Diseases
title_full_unstemmed Galectin-2 in Health and Diseases
title_short Galectin-2 in Health and Diseases
title_sort galectin-2 in health and diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820181/
https://www.ncbi.nlm.nih.gov/pubmed/36613785
http://dx.doi.org/10.3390/ijms24010341
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