Cargando…

Increasing Stress to Induce Apoptosis in Pancreatic Cancer via the Unfolded Protein Response (UPR)

High rates of cell proliferation and protein synthesis in pancreatic cancer are among many factors leading to endoplasmic reticulum (ER) stress. To restore cellular homeostasis, the unfolded protein response (UPR) activates as an adaptive mechanism through either the IRE1 [Formula: see text] , PERK,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Botrus, Gehan, Miller, Richard M., Uson Junior, Pedro Luiz Serrano, Kannan, Geoffrey, Han, Haiyong, Von Hoff, Daniel D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Hypothesis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820188/ https://www.ncbi.nlm.nih.gov/pubmed/36614019 http://dx.doi.org/10.3390/ijms24010577

Ejemplares similares

Precision Medicine Targeting FGFR2 Genomic Alterations in Advanced Cholangiocarcinoma: Current State and Future Perspectives
por: Zugman, Miguel, et al.
Publicado: (2022)

Mitomycin C in Homologous Recombination Deficient Metastatic Pancreatic Cancer after Disease Progression on Platinum-Based Chemotherapy and Olaparib
por: Botrus, Gehan, et al.
Publicado: (2022)

Hypothesis: The unfolding power of protein dielectricity
por: Uversky, Vladimir N
Publicado: (2013)

High temperature unfolding of Bacillus anthracis amidase-03 by molecular dynamics simulations
por: Sharma, Ravi Datta, et al.
Publicado: (2009)

mtDNA, Metastasis, and the Mitochondrial Unfolded Protein Response (UPR(mt))
por: Kenny, Timothy C., et al.
Publicado: (2017)

The Role of the Hypoxia-Related Unfolded Protein Response (UPR) in the Tumor Microenvironment
por: Bartoszewska, Sylwia, et al.
Publicado: (2022)

The mitochondrial unfolded protein response (UPR(mt)) protects against osteoarthritis
por: Zhou, Zhibin, et al.
Publicado: (2022)

Autophagy and unfolded protein response (UPR) regulate mammary gland involution by restraining apoptosis-driven irreversible changes
por: Wärri, Anni, et al.
Publicado: (2018)

Editorial: Unfolded protein response (UPR): An impending target for multiple neurological disorders
por: Jan, Arif Tasleem, et al.
Publicado: (2022)

Response to Abemaciclib and Immunotherapy Rechallenge with Nivolumab and Ipilimumab in a Heavily Pretreated TMB-H Metastatic Squamous Cell Lung Cancer with CDKN2A Mutation, PIK3CA Amplification and TPS 80%: A Case Report
por: Dias e Silva, Douglas, et al.
Publicado: (2023)

Apoptosis and signalling in acid sphingomyelinase deficient cells
por: Sillence, Dan J
Publicado: (2001)

Does Apoptosis Regulate the Function of Retinal Photoreceptors?
por: Halaby, Reginald
Publicado: (2012)

Development of a less toxic dichloroacetate analogue by docking and descriptor analysis
por: Subramanian, Kannan, et al.
Publicado: (2010)

Myofibroblasts and their resistance to apoptosis: a possible mechanism of osteoradionecrosis
por: Tian, Lei, et al.
Publicado: (2012)

Circulating Cell-Free Tumor DNA in Advanced Pancreatic Adenocarcinoma Identifies Patients With Worse Overall Survival
por: Botrus, Gehan, et al.
Publicado: (2022)

The human placenta releases substances that drive lung cancer into apoptosis
por: Marwitz, Sebastian, et al.
Publicado: (2009)

A Role for the Unfolded Protein Response (UPR) in Virulence and Antifungal Susceptibility in Aspergillus fumigatus
por: Richie, Daryl L., et al.
Publicado: (2009)

PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR)
por: Kranz, Philip, et al.
Publicado: (2017)

Unfolded Protein Response (UPR) in Survival, Dormancy, Immunosuppression, Metastasis, and Treatments of Cancer Cells
por: Hsu, Sheng-Kai, et al.
Publicado: (2019)

Contribution of the Unfolded Protein Response (UPR) to the Pathogenesis of Proteasome-Associated Autoinflammatory Syndromes (PRAAS)
por: Ebstein, Frédéric, et al.
Publicado: (2019)

Diclofenac Diminished the Unfolded Protein Response (UPR) Induced by Tunicamycin in Human Endothelial Cells
por: Sokołowska, Paulina, et al.
Publicado: (2022)

The mitochondrial unfolded protein response (UPR(mt)): shielding against toxicity to mitochondria in cancer
por: Inigo, Joseph R., et al.
Publicado: (2022)

Homology modeling, simulation and molecular docking studies of catechol-2, 3-Dioxygenase from Burkholderia cepacia: Involved in degradation of Petroleum hydrocarbons
por: Ajao, AT, et al.
Publicado: (2012)

Targeting the Stromal Pro-Tumoral Hyaluronan-CD44 Pathway in Pancreatic Cancer
por: Koltai, Tomas, et al.
Publicado: (2021)

in silico identification of cross affinity towards Cry1Ac pesticidal protein with receptor enzyme in Bos taurus and sequence, structure analysis of crystal proteins for stability
por: Ebenezer, King Solomon, et al.
Publicado: (2013)

Neoadjuvant chemotherapy or upfront surgery in localized pancreatic cancer: a contemporary analysis
por: Uson Junior, Pedro Luiz Serrano, et al.
Publicado: (2022)

Analysis of gene expression on ngn3 gene signaling pathway in endocrine pancreatic cancer
por: Nagaraja, Prashantha, et al.
Publicado: (2013)

CXCL12 in Pancreatic Cancer: Its Function and Potential as a Therapeutic Drug Target
por: Malik, Shivani, et al.
Publicado: (2021)

Effect of Hexadecyl Azelaoyl Phosphatidylcholine on Cardiomyocyte Apoptosis in Myocardial Ischemia-Reperfusion Injury: A Hypothesis
por: Feng, Limin, et al.
Publicado: (2018)

Insights from the analysis of conserved motifs and permitted amino acid exchanges in the human, the fly and the worm GPCR clusters
por: Nagarathnam, Balasubramanian, et al.
Publicado: (2011)

Disrupting the Balance between Tumor Epithelia and Stroma is a Possible Therapeutic Approach for Pancreatic Cancer
por: Wang, Zheng, et al.
Publicado: (2014)

Nonalcoholic fatty pancreatic disease and cardio-metabolic risk: is there is a place for obstructive sleep apnea?
por: Mirrakhimov, Aibek E
Publicado: (2014)

Shape based virtual screening and molecular docking towards designing novel pancreatic lipase inhibitors
por: Veeramachaneni, Ganesh Kumar, et al.
Publicado: (2015)

Discovery of Genes Activated by the Mitochondrial Unfolded Protein Response (mtUPR) and Cognate Promoter Elements
por: Aldridge, Jonathan E., et al.
Publicado: (2007)

Evidence against upstream regulation of the unfolded protein response (UPR) by pro-apoptotic BIM and PUMA
por: Herold, M J, et al.
Publicado: (2014)

Evolutionarily Conserved and Divergent Roles of Unfolded Protein Response (UPR) in the Pathogenic Cryptococcus Species Complex
por: Jung, Kwang-Woo, et al.
Publicado: (2018)

Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia
por: Bartoszewska, Sylwia, et al.
Publicado: (2020)

Modeling and structural analysis of cellulases using Clostridium thermocellum as template
por: Kumar, Nathan Vinod, et al.
Publicado: (2012)

The necessity of an observational study on the interactions between allergic history and citrus fruit intake for the prevention of pancreatic cancer
por: Bae, Jong-Myon
Publicado: (2015)

Genome increase as a clock for the origin and evolution of life
por: Sharov, Alexei A
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_ktm74a4dev4drub40jf1k9vsvd