Cargando…

Impact on the Clinical Evolution of Patients with COVID-19 Pneumonia and the Participation of the NFE2L2/KEAP1 Polymorphisms in Regulating SARS-CoV-2 Infection

In patients with severe pneumonia due to COVID-19, the deregulation of oxidative stress is present. Nuclear erythroid factor 2 (NRF2) is regulated by KEAP1, and NRF2 regulates the expression of genes such as NFE2L2-KEAP1, which are involved in cellular defense against oxidative stress. In this study...

Descripción completa

Detalles Bibliográficos
Autores principales: Soto, María Elena, Fuentevilla-Álvarez, Giovanny, Palacios-Chavarría, Adrián, Vázquez, Rafael Ricardo Valdez, Herrera-Bello, Héctor, Moreno-Castañeda, Lidia, Torres-Paz, Yazmín Estela, González-Moyotl, Nadia Janet, Pérez-Torres, Idalia, Aisa-Alvarez, Alfredo, Manzano-Pech, Linaloe, Pérez-Torres, Israel, Huesca-Gómez, Claudia, Gamboa, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820269/
https://www.ncbi.nlm.nih.gov/pubmed/36613859
http://dx.doi.org/10.3390/ijms24010415
_version_ 1784865426129289216
author Soto, María Elena
Fuentevilla-Álvarez, Giovanny
Palacios-Chavarría, Adrián
Vázquez, Rafael Ricardo Valdez
Herrera-Bello, Héctor
Moreno-Castañeda, Lidia
Torres-Paz, Yazmín Estela
González-Moyotl, Nadia Janet
Pérez-Torres, Idalia
Aisa-Alvarez, Alfredo
Manzano-Pech, Linaloe
Pérez-Torres, Israel
Huesca-Gómez, Claudia
Gamboa, Ricardo
author_facet Soto, María Elena
Fuentevilla-Álvarez, Giovanny
Palacios-Chavarría, Adrián
Vázquez, Rafael Ricardo Valdez
Herrera-Bello, Héctor
Moreno-Castañeda, Lidia
Torres-Paz, Yazmín Estela
González-Moyotl, Nadia Janet
Pérez-Torres, Idalia
Aisa-Alvarez, Alfredo
Manzano-Pech, Linaloe
Pérez-Torres, Israel
Huesca-Gómez, Claudia
Gamboa, Ricardo
author_sort Soto, María Elena
collection PubMed
description In patients with severe pneumonia due to COVID-19, the deregulation of oxidative stress is present. Nuclear erythroid factor 2 (NRF2) is regulated by KEAP1, and NRF2 regulates the expression of genes such as NFE2L2-KEAP1, which are involved in cellular defense against oxidative stress. In this study, we analyzed the participation of the polymorphisms of NFE2L2 and KEAP1 genes in the mechanisms of damage in lung disease patients with SARS-CoV-2 infection. Patients with COVID-19 and a control group were included. Organ dysfunction was evaluated using SOFA. SARS-CoV-2 infection was confirmed and classified as moderate or severe by ventilatory status and by the Berlin criteria for acute respiratory distress syndrome. SNPs in the gene locus for NFE2L2, rs2364723C>G, and KEAP1, rs9676881A>G, and rs34197572C>T were determined by qPCR. We analyzed 110 individuals with SARS-CoV-2 infection: 51 with severe evolution and 59 with moderate evolution. We also analyzed 111 controls. Significant differences were found for rs2364723 allele G in severe cases vs. controls (p = 0.02); for the rs9676881 allele G in moderate cases vs. controls (p = 0.04); for the rs34197572 allele T in severe cases vs. controls (p = 0.001); and in severe vs. moderate cases (p = 0.004). Our results showed that NFE2L2 rs2364723C>G allele G had a protective effect against severe COVID-19, while KEAP1 rs9676881A>G allele G and rs34197572C>T minor allele T were associated with more aggressive stages of COVID-19.
format Online
Article
Text
id pubmed-9820269
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98202692023-01-07 Impact on the Clinical Evolution of Patients with COVID-19 Pneumonia and the Participation of the NFE2L2/KEAP1 Polymorphisms in Regulating SARS-CoV-2 Infection Soto, María Elena Fuentevilla-Álvarez, Giovanny Palacios-Chavarría, Adrián Vázquez, Rafael Ricardo Valdez Herrera-Bello, Héctor Moreno-Castañeda, Lidia Torres-Paz, Yazmín Estela González-Moyotl, Nadia Janet Pérez-Torres, Idalia Aisa-Alvarez, Alfredo Manzano-Pech, Linaloe Pérez-Torres, Israel Huesca-Gómez, Claudia Gamboa, Ricardo Int J Mol Sci Article In patients with severe pneumonia due to COVID-19, the deregulation of oxidative stress is present. Nuclear erythroid factor 2 (NRF2) is regulated by KEAP1, and NRF2 regulates the expression of genes such as NFE2L2-KEAP1, which are involved in cellular defense against oxidative stress. In this study, we analyzed the participation of the polymorphisms of NFE2L2 and KEAP1 genes in the mechanisms of damage in lung disease patients with SARS-CoV-2 infection. Patients with COVID-19 and a control group were included. Organ dysfunction was evaluated using SOFA. SARS-CoV-2 infection was confirmed and classified as moderate or severe by ventilatory status and by the Berlin criteria for acute respiratory distress syndrome. SNPs in the gene locus for NFE2L2, rs2364723C>G, and KEAP1, rs9676881A>G, and rs34197572C>T were determined by qPCR. We analyzed 110 individuals with SARS-CoV-2 infection: 51 with severe evolution and 59 with moderate evolution. We also analyzed 111 controls. Significant differences were found for rs2364723 allele G in severe cases vs. controls (p = 0.02); for the rs9676881 allele G in moderate cases vs. controls (p = 0.04); for the rs34197572 allele T in severe cases vs. controls (p = 0.001); and in severe vs. moderate cases (p = 0.004). Our results showed that NFE2L2 rs2364723C>G allele G had a protective effect against severe COVID-19, while KEAP1 rs9676881A>G allele G and rs34197572C>T minor allele T were associated with more aggressive stages of COVID-19. MDPI 2022-12-27 /pmc/articles/PMC9820269/ /pubmed/36613859 http://dx.doi.org/10.3390/ijms24010415 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Soto, María Elena
Fuentevilla-Álvarez, Giovanny
Palacios-Chavarría, Adrián
Vázquez, Rafael Ricardo Valdez
Herrera-Bello, Héctor
Moreno-Castañeda, Lidia
Torres-Paz, Yazmín Estela
González-Moyotl, Nadia Janet
Pérez-Torres, Idalia
Aisa-Alvarez, Alfredo
Manzano-Pech, Linaloe
Pérez-Torres, Israel
Huesca-Gómez, Claudia
Gamboa, Ricardo
Impact on the Clinical Evolution of Patients with COVID-19 Pneumonia and the Participation of the NFE2L2/KEAP1 Polymorphisms in Regulating SARS-CoV-2 Infection
title Impact on the Clinical Evolution of Patients with COVID-19 Pneumonia and the Participation of the NFE2L2/KEAP1 Polymorphisms in Regulating SARS-CoV-2 Infection
title_full Impact on the Clinical Evolution of Patients with COVID-19 Pneumonia and the Participation of the NFE2L2/KEAP1 Polymorphisms in Regulating SARS-CoV-2 Infection
title_fullStr Impact on the Clinical Evolution of Patients with COVID-19 Pneumonia and the Participation of the NFE2L2/KEAP1 Polymorphisms in Regulating SARS-CoV-2 Infection
title_full_unstemmed Impact on the Clinical Evolution of Patients with COVID-19 Pneumonia and the Participation of the NFE2L2/KEAP1 Polymorphisms in Regulating SARS-CoV-2 Infection
title_short Impact on the Clinical Evolution of Patients with COVID-19 Pneumonia and the Participation of the NFE2L2/KEAP1 Polymorphisms in Regulating SARS-CoV-2 Infection
title_sort impact on the clinical evolution of patients with covid-19 pneumonia and the participation of the nfe2l2/keap1 polymorphisms in regulating sars-cov-2 infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820269/
https://www.ncbi.nlm.nih.gov/pubmed/36613859
http://dx.doi.org/10.3390/ijms24010415
work_keys_str_mv AT sotomariaelena impactontheclinicalevolutionofpatientswithcovid19pneumoniaandtheparticipationofthenfe2l2keap1polymorphismsinregulatingsarscov2infection
AT fuentevillaalvarezgiovanny impactontheclinicalevolutionofpatientswithcovid19pneumoniaandtheparticipationofthenfe2l2keap1polymorphismsinregulatingsarscov2infection
AT palacioschavarriaadrian impactontheclinicalevolutionofpatientswithcovid19pneumoniaandtheparticipationofthenfe2l2keap1polymorphismsinregulatingsarscov2infection
AT vazquezrafaelricardovaldez impactontheclinicalevolutionofpatientswithcovid19pneumoniaandtheparticipationofthenfe2l2keap1polymorphismsinregulatingsarscov2infection
AT herrerabellohector impactontheclinicalevolutionofpatientswithcovid19pneumoniaandtheparticipationofthenfe2l2keap1polymorphismsinregulatingsarscov2infection
AT morenocastanedalidia impactontheclinicalevolutionofpatientswithcovid19pneumoniaandtheparticipationofthenfe2l2keap1polymorphismsinregulatingsarscov2infection
AT torrespazyazminestela impactontheclinicalevolutionofpatientswithcovid19pneumoniaandtheparticipationofthenfe2l2keap1polymorphismsinregulatingsarscov2infection
AT gonzalezmoyotlnadiajanet impactontheclinicalevolutionofpatientswithcovid19pneumoniaandtheparticipationofthenfe2l2keap1polymorphismsinregulatingsarscov2infection
AT pereztorresidalia impactontheclinicalevolutionofpatientswithcovid19pneumoniaandtheparticipationofthenfe2l2keap1polymorphismsinregulatingsarscov2infection
AT aisaalvarezalfredo impactontheclinicalevolutionofpatientswithcovid19pneumoniaandtheparticipationofthenfe2l2keap1polymorphismsinregulatingsarscov2infection
AT manzanopechlinaloe impactontheclinicalevolutionofpatientswithcovid19pneumoniaandtheparticipationofthenfe2l2keap1polymorphismsinregulatingsarscov2infection
AT pereztorresisrael impactontheclinicalevolutionofpatientswithcovid19pneumoniaandtheparticipationofthenfe2l2keap1polymorphismsinregulatingsarscov2infection
AT huescagomezclaudia impactontheclinicalevolutionofpatientswithcovid19pneumoniaandtheparticipationofthenfe2l2keap1polymorphismsinregulatingsarscov2infection
AT gamboaricardo impactontheclinicalevolutionofpatientswithcovid19pneumoniaandtheparticipationofthenfe2l2keap1polymorphismsinregulatingsarscov2infection