Blocking Muscarinic Receptor 3 Attenuates Tumor Growth and Decreases Immunosuppressive and Cholinergic Markers in an Orthotopic Mouse Model of Colorectal Cancer

Tumor cells have evolved to express immunosuppressive molecules allowing their evasion from the host’s immune system. These molecules include programmed death ligands 1 and 2 (PD-L1 and PD-L2). Cancer cells can also produce acetylcholine (ACh), which plays a role in tumor development. Moreover, tumo...

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Detalles Bibliográficos
Autores principales: Kuol, Nyanbol, Davidson, Majid, Karakkat, Jimsheena, Filippone, Rhiannon T., Veale, Margaret, Luwor, Rodney, Fraser, Sarah, Apostolopoulos, Vasso, Nurgali, Kulmira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820315/
https://www.ncbi.nlm.nih.gov/pubmed/36614038
http://dx.doi.org/10.3390/ijms24010596

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