Cargando…

Autophagy and Apoptosis: Current Challenges of Treatment and Drug Resistance in Multiple Myeloma

Over the past two decades, the natural history of multiple myeloma (MM) has evolved dramatically, owing primarily to novel agents targeting MM in the bone marrow microenvironment (BMM) pathways. However, the mechanisms of resistance acquisition remain a mystery and are poorly understood. Autophagy a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Al-Odat, Omar S., Guirguis, Daniel A., Schmalbach, Nicole K., Yao, Gabriella, Budak-Alpdogan, Tulin, Jonnalagadda, Subash C., Pandey, Manoj K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820338/ https://www.ncbi.nlm.nih.gov/pubmed/36614089 http://dx.doi.org/10.3390/ijms24010644

Ejemplares similares

Past, Present, and a Glance into the Future of Multiple Myeloma Treatment
por: Elbezanti, Weam Othman, et al.
Publicado: (2023)

Bruton’s Tyrosine Kinase Targeting in Multiple Myeloma
por: Von Suskil, Max, et al.
Publicado: (2021)

Mcl-1 Inhibition: Managing Malignancy in Multiple Myeloma
por: Al-Odat, Omar S., et al.
Publicado: (2021)

Development of a novel Bruton’s tyrosine kinase inhibitor that exerts anti-cancer activities potentiates response of chemotherapeutic agents in multiple myeloma stem cell-like cells
por: Elbezanti, Weam Othman, et al.
Publicado: (2022)

Promyelocytic Blast Crisis of Chronic Myeloid Leukemia in a Patient Undergoing Therapy with a Tyrosine Kinase Inhibitor
por: Parsi, Meghana, et al.
Publicado: (2020)

Current Role of Radiation Therapy for Multiple Myeloma
por: Talamo, Giampaolo, et al.
Publicado: (2015)

New interleukin-15 superagonist (IL-15SA) significantly enhances graft-versus-tumor activity
por: Bailey, Cavan P., et al.
Publicado: (2017)

Solamargine induces autophagy‐mediated apoptosis and enhances bortezomib activity in multiple myeloma
por: Han, Qiaoyan, et al.
Publicado: (2022)

Emodin Ameliorates the Efficacy of Carfilzomib in Multiple Myeloma Cells via Apoptosis and Autophagy
por: Hsu, Chin-Mu, et al.
Publicado: (2022)

Cobblestone-Area Forming Cells Derived from Patients with Mantle Cell Lymphoma Are Enriched for CD133(+) Tumor-Initiating Cells
por: Medina, Daniel J., et al.
Publicado: (2014)

Role of Wnt/β-catenin pathway in inducing autophagy and apoptosis in multiple myeloma cells
por: Su, Nan, et al.
Publicado: (2016)

Trifluoperazine induces cellular apoptosis by inhibiting autophagy and targeting NUPR1 in multiple myeloma
por: Li, Anmao, et al.
Publicado: (2020)

Oxidative Stress and Cancer: Advances and Challenges
por: Prasad, Sahdeo, et al.
Publicado: (2016)

Synthesis, in vitro, and in vivo evaluation of novel N-phenylindazolyl diarylureas as potential anti-cancer agents
por: Solano, Lucas N., et al.
Publicado: (2020)

Central Neurotoxicity of Immunomodulatory Drugs in Multiple Myeloma
por: Patel, Urmeel H., et al.
Publicado: (2015)

Cellular Immunotherapies for Multiple Myeloma: Current Status, Challenges, and Future Directions
por: Yan, Zhi-Ling, et al.
Publicado: (2022)

CAR T-Cell Therapy for Patients with Multiple Myeloma: Current Evidence and Challenges
por: Rendo, Matthew J, et al.
Publicado: (2022)

Stem cell mobilization in multiple myeloma: challenges, strategies, and current developments
por: Wei, Xiaolei, et al.
Publicado: (2023)

Hydrogel-Encapsulated Heterogenous Mesoporous Resin Catalyst for In Situ Anti-Cancer Agent Production under Biological Conditions
por: Nabavinia, Mahboubeh, et al.
Publicado: (2022)

Targeting autophagy increases the efficacy of proteasome inhibitor treatment in multiple myeloma by induction of apoptosis and activation of JNK
por: Salimi, Azam, et al.
Publicado: (2022)

Bortezomib Treatment Modulates Autophagy in Multiple Myeloma
por: Di Lernia, Giuseppe, et al.
Publicado: (2020)

Dual Targeting to Overcome Current Challenges in Multiple Myeloma CAR T-Cell Treatment
por: van der Schans, Jort J., et al.
Publicado: (2020)

T-Cell-Based Cellular Immunotherapy of Multiple Myeloma: Current Developments
por: Simmons, Gary L., et al.
Publicado: (2022)

Induction of Apoptosis, Autophagy and Ferroptosis by Thymus vulgaris and Arctium lappa Extract in Leukemia and Multiple Myeloma Cell Lines
por: N. Adham, Aveen, et al.
Publicado: (2020)

Multiple Myeloma Therapy: Emerging Trends and Challenges
por: Dima, Danai, et al.
Publicado: (2022)

Apoptosis and Autophagy: Current Understanding in Tick–Pathogen Interactions
por: Wang, Xin-Ru, et al.
Publicado: (2022)

Alpha Particles Induce Autophagy in Multiple Myeloma Cells
por: Gorin, Jean-Baptiste, et al.
Publicado: (2015)

Dihydroartemisinin Modulates Apoptosis and Autophagy in Multiple Myeloma through the P38/MAPK and Wnt/β-Catenin Signaling Pathways
por: Wu, Xiuhua, et al.
Publicado: (2020)

microRNA‐637 promotes apoptosis and suppresses proliferation and autophagy in multiple myeloma cell lines via NUPR1
por: Chen, Xuanxin, et al.
Publicado: (2020)

P53 regulates the migration of mesenchymal stromal cells in response to the tumor microenvironment through both CXCL12-dependent and -independent mechanisms
por: LIN, SIANG-YO, et al.
Publicado: (2013)

Multiple myeloma current treatment algorithms
por: Rajkumar, S. Vincent, et al.
Publicado: (2020)

Current and Novel Alkylators in Multiple Myeloma
por: Schjesvold, Fredrik, et al.
Publicado: (2021)

Current Main Topics in Multiple Myeloma
por: Morè, Sonia, et al.
Publicado: (2023)

Current and Emerging Treatments for Multiple Myeloma
por: Schwartz, Rowena N., et al.
Publicado: (2008)

Immunotherapy of Multiple Myeloma: Promise and Challenges
por: Abramson, Hanley N
Publicado: (2021)

Late-Onset Posttransplant Lymphoproliferative Disorders after Solid Organ Transplantation in Adults: A Case Series and Review of the Literature
por: Gandhi, S., et al.
Publicado: (2020)

Inhibition of autophagy enhances the antitumour activity of tigecycline in multiple myeloma
por: Ma, Ruye, et al.
Publicado: (2018)

The Role of Chaperone-Mediated Autophagy in Bortezomib Resistant Multiple Myeloma
por: Nikesitch, Nicholas, et al.
Publicado: (2021)

Current Role of Allogeneic Stem Cell Transplantation in Multiple Myeloma
por: Claveau, Jean-Sébastien, et al.
Publicado: (2022)

Polydatin regulates proliferation, apoptosis and autophagy in multiple myeloma cells through mTOR/p70s6k pathway
por: Yang, Baojun, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_iebpc7mph7883oj9sgl9v63dh0