Cargando…

Metabolic Activation of Benzo[a]pyrene by Human Tissue Organoid Cultures

Organoids are 3D cultures that to some extent reproduce the structure, composition and function of the mammalian tissues from which they derive, thereby creating in vitro systems with more in vivo-like characteristics than 2D monocultures. Here, the ability of human organoids derived from normal gas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Caipa Garcia, Angela L., Kucab, Jill E., Al-Serori, Halh, Beck, Rebekah S. S., Fischer, Franziska, Hufnagel, Matthias, Hartwig, Andrea, Floeder, Andrew, Balbo, Silvia, Francies, Hayley, Garnett, Mathew, Huch, Meritxell, Drost, Jarno, Zilbauer, Matthias, Arlt, Volker M., Phillips, David H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820386/ https://www.ncbi.nlm.nih.gov/pubmed/36614051 http://dx.doi.org/10.3390/ijms24010606

Ejemplares similares

Influence of cell cycle on responses of MCF-7 cells to benzo[a]pyrene
por: Hamouchene, Hamza, et al.
Publicado: (2011)

Disease modelling in human organoids
por: Lancaster, Madeline A., et al.
Publicado: (2019)

UVA Photoirradiation of Methylated Benzo[a]pyrene and Benzo[e]pyrene leading to Induction of Lipid Peroxidation
por: Sáenz, Diógenes Herreño, et al.
Publicado: (2007)

Biobanking of human gut organoids for translational research
por: Perrone, Francesca, et al.
Publicado: (2021)

Organoids for toxicology and genetic toxicology: applications with drugs and prospects for environmental carcinogenesis
por: Caipa Garcia, Angela L, et al.
Publicado: (2021)

Bacillus subtilis is a Potential Degrader of Pyrene and Benzo[a]pyrene
por: Hunter, Rochelle D., et al.
Publicado: (2005)

Intestinal Epithelial Organoids as Tools to Study Epigenetics in Gut Health and Disease
por: Kraiczy, Judith, et al.
Publicado: (2019)

Changes of biomarkers with oral exposure to benzo(a)pyrene, phenanthrene and pyrene in rats
por: Kang, Hwan Goo, et al.
Publicado: (2007)

Free radicals of benzo(a)pyrene and derivatives.
por: Sullivan, P D
Publicado: (1985)

Liver organoids: from basic research to therapeutic applications
por: Prior, Nicole, et al.
Publicado: (2019)

Normal and tumor-derived organoids as a drug screening platform for tumor-specific drug vulnerabilities
por: Calandrini, Camilla, et al.
Publicado: (2022)

Subchronic Oral Exposure to Benzo(a)pyrene Leads to Distinct Transcriptomic Changes in the Lungs That Are Related to Carcinogenesis
por: Labib, Sarah, et al.
Publicado: (2012)

The impact of individual cytochrome P450 enzymes on oxidative metabolism of benzo[a]pyrene in human livers
por: Šulc, Miroslav, et al.
Publicado: (2016)

Quantitation of exposure to benzo[a]pyrene with monoclonal antibodies.
por: Santella, R M, et al.
Publicado: (1985)

Influence of Benzo(a)pyrene on Different Epigenetic Processes
por: Bukowska, Bożena, et al.
Publicado: (2021)

Benzo[a]pyrene and Benzo[k]fluoranthene in Some Processed Fish and Fish Products
por: Olatunji, Olatunde S., et al.
Publicado: (2015)

Xenograft and organoid model systems in cancer research
por: Bleijs, Margit, et al.
Publicado: (2019)

Enhanced DNA adduct formation by benzo[a]pyrene in human liver cells lacking cytochrome P450 oxidoreductase
por: Reed, Lindsay, et al.
Publicado: (2020)

Benzo[a]pyrene-Induced Genotoxicity in Rats Is Affected by Co-Exposure to Sudan I by Altering the Expression of Biotransformation Enzymes
por: Dračínská, Helena, et al.
Publicado: (2021)

Benzo[a]pyrene and Caenorhabditis elegans: defining the genotoxic potential in an organism lacking the classical CYP1A1 pathway
por: Abbass, Mustafa, et al.
Publicado: (2021)

Transcriptional profiling of the mouse hippocampus supports an NMDAR‐mediated neurotoxic mode of action for benzo[a]pyrene
por: Chepelev, Nikolai L., et al.
Publicado: (2016)

Inflammation-associated extracellular β-glucuronidase alters cellular responses to the chemical carcinogen benzo[a]pyrene
por: Shi, Q., et al.
Publicado: (2015)

Formation and persistence of benzo(a)pyrene metabolite-DNA adducts.
por: Stowers, S J, et al.
Publicado: (1985)

Chemoresistance to Cancer Treatment: Benzo-α-Pyrene as Friend or Foe?
por: Dzobo, Kevin, et al.
Publicado: (2018)

Modulatory Effects of Silymarin on Benzo[a]pyrene-Induced Hepatotoxicity
por: Jee, Seung-Cheol, et al.
Publicado: (2020)

Antagonistic Interactions between Benzo[a]pyrene and Fullerene (C(60)) in Toxicological Response of Marine Mussels
por: Barranger, Audrey, et al.
Publicado: (2019)

Insight into the High-Efficiency Benzo(a)pyrene Degradation Ability of Pseudomonas benzopyrenica BaP3 and Its Application in the Complete Bioremediation of Benzo(a)pyrene
por: Dong, Xingchen, et al.
Publicado: (2023)

Altered gene expression profiles in the lungs of benzo[a]pyrene-exposed mice in the presence of lipopolysaccharide-induced pulmonary inflammation()
por: Shi, Q., et al.
Publicado: (2017)

Benzo [Image: see text] pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice
por: Zuo, Jie, et al.
Publicado: (2014)

Biotransformation of benzo[a]pyrene by Pannonibacter sp. JPA3 and the degradation mechanism through the initially oxidized benzo[a]pyrene-4,5-dihydrodiol to downstream metabolites
por: Jin, Jingnan, et al.
Publicado: (2023)

The carcinogenicity of some 6-substituted benzo(a)pyrene derivatives in mice.
por: Dewhurst, F., et al.
Publicado: (1972)

The development of abdominal aortic aneurysms in mice is enhanced by benzo(a)pyrene
por: Zhang, Yong, et al.
Publicado: (2008)

Proceedings: Metabolites of benzo (A) pyrene (BP) which bind to DNA.
por: King, H. W., et al.
Publicado: (1975)

Effect of chrysotile asbestos and silica on the microsomal metabolism of benzo(a)pyrene.
por: Kandaswami, C, et al.
Publicado: (1983)

Transcriptional signatures of regulatory and toxic responses to benzo-[a]-pyrene exposure
por: Michaelson, Jacob J, et al.
Publicado: (2011)

Chlorophyll catalyse the photo-transformation of carcinogenic benzo[a]pyrene in water
por: Luo, Lijuan, et al.
Publicado: (2015)

Overexpression of Catalase Enhances Benzo(a)pyrene Detoxification in Endothelial Microsomes
por: Yang, Fang, et al.
Publicado: (2016)

Benzo(a)pyrene triggers desensitization of β2-adrenergic pathway
por: Mayati, Abdullah, et al.
Publicado: (2017)

Current Status of and Future Perspectives in Bacterial Degradation of Benzo[a]pyrene
por: Nzila, Alexis, et al.
Publicado: (2020)

Benzo[a]pyrene—Environmental Occurrence, Human Exposure, and Mechanisms of Toxicity
por: Bukowska, Bożena, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5dk921slo61isii9f6h55a1la9