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Circadian Rhythm Disorders Aggravate Periodontitis by Modulating BMAL1

Circadian rhythms regulate the body’s homeostasis through the temporal control of tissue-specific circadian rhythm control genes. Circadian rhythm disorders (CRD) affect the expression levels of circadian rhythms-associated genes in brain and muscle aryl hydrocarbon receptor nuclear translocator-lik...

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Autores principales: Liu, Xiaomeng, Cao, Niuben, Liu, Xinchan, Deng, Yu, Xin, Yu, Fu, Ruobing, Xin, Xirui, Hou, Yubo, Yu, Weixian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820395/
https://www.ncbi.nlm.nih.gov/pubmed/36613816
http://dx.doi.org/10.3390/ijms24010374
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author Liu, Xiaomeng
Cao, Niuben
Liu, Xinchan
Deng, Yu
Xin, Yu
Fu, Ruobing
Xin, Xirui
Hou, Yubo
Yu, Weixian
author_facet Liu, Xiaomeng
Cao, Niuben
Liu, Xinchan
Deng, Yu
Xin, Yu
Fu, Ruobing
Xin, Xirui
Hou, Yubo
Yu, Weixian
author_sort Liu, Xiaomeng
collection PubMed
description Circadian rhythms regulate the body’s homeostasis through the temporal control of tissue-specific circadian rhythm control genes. Circadian rhythm disorders (CRD) affect the expression levels of circadian rhythms-associated genes in brain and muscle aryl hydrocarbon receptor nuclear translocator-like-1(BMAL1), which is thought to contribute to metabolic disorders and an altered immune system. However, the relationship between CRD and the development of periodontitis was poorly reported. Therefore, this study aimed to investigate the role played by BMAL1 in periodontitis. We used a modified multi-platform approach (MMPM) to induce circadian rhythm disturbances in rats to investigate the role of BMAL1 in periodontitis. Our results showed significant downregulation of BMAL1 in the CRD with periodontitis group, significant resorption of alveolar bone, increased osteoclast differentiation, and upregulation of the inflammatory signaling molecule NF-κB. In addition, apoptosis and oxidative stress levels were increased in periodontal tissues. Collectively, our study suggests that BMAL1 is a key regulator in periodontitis exacerbated by CRD and that CRD may lead to the downregulation of BMAL1, thereby exacerbating oxidative stress and apoptosis in periodontal tissues. Our study found that BMAL1 may be associated with the progression of periodontitis and provides a new perspective on the treatment of periodontitis.
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spelling pubmed-98203952023-01-07 Circadian Rhythm Disorders Aggravate Periodontitis by Modulating BMAL1 Liu, Xiaomeng Cao, Niuben Liu, Xinchan Deng, Yu Xin, Yu Fu, Ruobing Xin, Xirui Hou, Yubo Yu, Weixian Int J Mol Sci Article Circadian rhythms regulate the body’s homeostasis through the temporal control of tissue-specific circadian rhythm control genes. Circadian rhythm disorders (CRD) affect the expression levels of circadian rhythms-associated genes in brain and muscle aryl hydrocarbon receptor nuclear translocator-like-1(BMAL1), which is thought to contribute to metabolic disorders and an altered immune system. However, the relationship between CRD and the development of periodontitis was poorly reported. Therefore, this study aimed to investigate the role played by BMAL1 in periodontitis. We used a modified multi-platform approach (MMPM) to induce circadian rhythm disturbances in rats to investigate the role of BMAL1 in periodontitis. Our results showed significant downregulation of BMAL1 in the CRD with periodontitis group, significant resorption of alveolar bone, increased osteoclast differentiation, and upregulation of the inflammatory signaling molecule NF-κB. In addition, apoptosis and oxidative stress levels were increased in periodontal tissues. Collectively, our study suggests that BMAL1 is a key regulator in periodontitis exacerbated by CRD and that CRD may lead to the downregulation of BMAL1, thereby exacerbating oxidative stress and apoptosis in periodontal tissues. Our study found that BMAL1 may be associated with the progression of periodontitis and provides a new perspective on the treatment of periodontitis. MDPI 2022-12-26 /pmc/articles/PMC9820395/ /pubmed/36613816 http://dx.doi.org/10.3390/ijms24010374 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Xiaomeng
Cao, Niuben
Liu, Xinchan
Deng, Yu
Xin, Yu
Fu, Ruobing
Xin, Xirui
Hou, Yubo
Yu, Weixian
Circadian Rhythm Disorders Aggravate Periodontitis by Modulating BMAL1
title Circadian Rhythm Disorders Aggravate Periodontitis by Modulating BMAL1
title_full Circadian Rhythm Disorders Aggravate Periodontitis by Modulating BMAL1
title_fullStr Circadian Rhythm Disorders Aggravate Periodontitis by Modulating BMAL1
title_full_unstemmed Circadian Rhythm Disorders Aggravate Periodontitis by Modulating BMAL1
title_short Circadian Rhythm Disorders Aggravate Periodontitis by Modulating BMAL1
title_sort circadian rhythm disorders aggravate periodontitis by modulating bmal1
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820395/
https://www.ncbi.nlm.nih.gov/pubmed/36613816
http://dx.doi.org/10.3390/ijms24010374
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