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Recent Advances in Cardiovascular Diseases Research Using Animal Models and PET Radioisotope Tracers
Cardiovascular diseases (CVD) is a collective term describing a range of conditions that affect the heart and blood vessels. Due to the varied nature of the disorders, distinguishing between their causes and monitoring their progress is crucial for finding an effective treatment. Molecular imaging e...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820417/ https://www.ncbi.nlm.nih.gov/pubmed/36613797 http://dx.doi.org/10.3390/ijms24010353 |
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author | Wargocka-Matuszewska, Weronika Uhrynowski, Witold Rozwadowska, Natalia Rogulski, Zbigniew |
author_facet | Wargocka-Matuszewska, Weronika Uhrynowski, Witold Rozwadowska, Natalia Rogulski, Zbigniew |
author_sort | Wargocka-Matuszewska, Weronika |
collection | PubMed |
description | Cardiovascular diseases (CVD) is a collective term describing a range of conditions that affect the heart and blood vessels. Due to the varied nature of the disorders, distinguishing between their causes and monitoring their progress is crucial for finding an effective treatment. Molecular imaging enables non-invasive visualisation and quantification of biological pathways, even at the molecular and subcellular levels, what is essential for understanding the causes and development of CVD. Positron emission tomography imaging is so far recognized as the best method for in vivo studies of the CVD related phenomena. The imaging is based on the use of radioisotope-labelled markers, which have been successfully used in both pre-clinical research and clinical studies. Current research on CVD with the use of such radioconjugates constantly increases our knowledge and understanding of the causes, and brings us closer to effective monitoring and treatment. This review outlines recent advances in the use of the so-far available radioisotope markers in the research on cardiovascular diseases in rodent models, points out the problems and provides a perspective for future applications of PET imaging in CVD studies. |
format | Online Article Text |
id | pubmed-9820417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98204172023-01-07 Recent Advances in Cardiovascular Diseases Research Using Animal Models and PET Radioisotope Tracers Wargocka-Matuszewska, Weronika Uhrynowski, Witold Rozwadowska, Natalia Rogulski, Zbigniew Int J Mol Sci Review Cardiovascular diseases (CVD) is a collective term describing a range of conditions that affect the heart and blood vessels. Due to the varied nature of the disorders, distinguishing between their causes and monitoring their progress is crucial for finding an effective treatment. Molecular imaging enables non-invasive visualisation and quantification of biological pathways, even at the molecular and subcellular levels, what is essential for understanding the causes and development of CVD. Positron emission tomography imaging is so far recognized as the best method for in vivo studies of the CVD related phenomena. The imaging is based on the use of radioisotope-labelled markers, which have been successfully used in both pre-clinical research and clinical studies. Current research on CVD with the use of such radioconjugates constantly increases our knowledge and understanding of the causes, and brings us closer to effective monitoring and treatment. This review outlines recent advances in the use of the so-far available radioisotope markers in the research on cardiovascular diseases in rodent models, points out the problems and provides a perspective for future applications of PET imaging in CVD studies. MDPI 2022-12-26 /pmc/articles/PMC9820417/ /pubmed/36613797 http://dx.doi.org/10.3390/ijms24010353 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wargocka-Matuszewska, Weronika Uhrynowski, Witold Rozwadowska, Natalia Rogulski, Zbigniew Recent Advances in Cardiovascular Diseases Research Using Animal Models and PET Radioisotope Tracers |
title | Recent Advances in Cardiovascular Diseases Research Using Animal Models and PET Radioisotope Tracers |
title_full | Recent Advances in Cardiovascular Diseases Research Using Animal Models and PET Radioisotope Tracers |
title_fullStr | Recent Advances in Cardiovascular Diseases Research Using Animal Models and PET Radioisotope Tracers |
title_full_unstemmed | Recent Advances in Cardiovascular Diseases Research Using Animal Models and PET Radioisotope Tracers |
title_short | Recent Advances in Cardiovascular Diseases Research Using Animal Models and PET Radioisotope Tracers |
title_sort | recent advances in cardiovascular diseases research using animal models and pet radioisotope tracers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820417/ https://www.ncbi.nlm.nih.gov/pubmed/36613797 http://dx.doi.org/10.3390/ijms24010353 |
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