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Recent Advances in Cardiovascular Diseases Research Using Animal Models and PET Radioisotope Tracers

Cardiovascular diseases (CVD) is a collective term describing a range of conditions that affect the heart and blood vessels. Due to the varied nature of the disorders, distinguishing between their causes and monitoring their progress is crucial for finding an effective treatment. Molecular imaging e...

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Autores principales: Wargocka-Matuszewska, Weronika, Uhrynowski, Witold, Rozwadowska, Natalia, Rogulski, Zbigniew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820417/
https://www.ncbi.nlm.nih.gov/pubmed/36613797
http://dx.doi.org/10.3390/ijms24010353
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author Wargocka-Matuszewska, Weronika
Uhrynowski, Witold
Rozwadowska, Natalia
Rogulski, Zbigniew
author_facet Wargocka-Matuszewska, Weronika
Uhrynowski, Witold
Rozwadowska, Natalia
Rogulski, Zbigniew
author_sort Wargocka-Matuszewska, Weronika
collection PubMed
description Cardiovascular diseases (CVD) is a collective term describing a range of conditions that affect the heart and blood vessels. Due to the varied nature of the disorders, distinguishing between their causes and monitoring their progress is crucial for finding an effective treatment. Molecular imaging enables non-invasive visualisation and quantification of biological pathways, even at the molecular and subcellular levels, what is essential for understanding the causes and development of CVD. Positron emission tomography imaging is so far recognized as the best method for in vivo studies of the CVD related phenomena. The imaging is based on the use of radioisotope-labelled markers, which have been successfully used in both pre-clinical research and clinical studies. Current research on CVD with the use of such radioconjugates constantly increases our knowledge and understanding of the causes, and brings us closer to effective monitoring and treatment. This review outlines recent advances in the use of the so-far available radioisotope markers in the research on cardiovascular diseases in rodent models, points out the problems and provides a perspective for future applications of PET imaging in CVD studies.
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spelling pubmed-98204172023-01-07 Recent Advances in Cardiovascular Diseases Research Using Animal Models and PET Radioisotope Tracers Wargocka-Matuszewska, Weronika Uhrynowski, Witold Rozwadowska, Natalia Rogulski, Zbigniew Int J Mol Sci Review Cardiovascular diseases (CVD) is a collective term describing a range of conditions that affect the heart and blood vessels. Due to the varied nature of the disorders, distinguishing between their causes and monitoring their progress is crucial for finding an effective treatment. Molecular imaging enables non-invasive visualisation and quantification of biological pathways, even at the molecular and subcellular levels, what is essential for understanding the causes and development of CVD. Positron emission tomography imaging is so far recognized as the best method for in vivo studies of the CVD related phenomena. The imaging is based on the use of radioisotope-labelled markers, which have been successfully used in both pre-clinical research and clinical studies. Current research on CVD with the use of such radioconjugates constantly increases our knowledge and understanding of the causes, and brings us closer to effective monitoring and treatment. This review outlines recent advances in the use of the so-far available radioisotope markers in the research on cardiovascular diseases in rodent models, points out the problems and provides a perspective for future applications of PET imaging in CVD studies. MDPI 2022-12-26 /pmc/articles/PMC9820417/ /pubmed/36613797 http://dx.doi.org/10.3390/ijms24010353 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wargocka-Matuszewska, Weronika
Uhrynowski, Witold
Rozwadowska, Natalia
Rogulski, Zbigniew
Recent Advances in Cardiovascular Diseases Research Using Animal Models and PET Radioisotope Tracers
title Recent Advances in Cardiovascular Diseases Research Using Animal Models and PET Radioisotope Tracers
title_full Recent Advances in Cardiovascular Diseases Research Using Animal Models and PET Radioisotope Tracers
title_fullStr Recent Advances in Cardiovascular Diseases Research Using Animal Models and PET Radioisotope Tracers
title_full_unstemmed Recent Advances in Cardiovascular Diseases Research Using Animal Models and PET Radioisotope Tracers
title_short Recent Advances in Cardiovascular Diseases Research Using Animal Models and PET Radioisotope Tracers
title_sort recent advances in cardiovascular diseases research using animal models and pet radioisotope tracers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820417/
https://www.ncbi.nlm.nih.gov/pubmed/36613797
http://dx.doi.org/10.3390/ijms24010353
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