Cargando…
Current Knowledge on the Pathophysiology of Lean/Normal-Weight Type 2 Diabetes
Since early times, being overweight and obesity have been associated with impaired glucose metabolism and type 2 diabetes (T2D). Similarly, a less frequent adult-onset diabetes in low body mass index (BMI) people has been known for many decades. This form is mainly found in developing countries, whe...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820420/ https://www.ncbi.nlm.nih.gov/pubmed/36614099 http://dx.doi.org/10.3390/ijms24010658 |
_version_ | 1784865461248196608 |
---|---|
author | Salvatore, Teresa Galiero, Raffaele Caturano, Alfredo Rinaldi, Luca Criscuolo, Livio Di Martino, Anna Albanese, Gaetana Vetrano, Erica Catalini, Christian Sardu, Celestino Docimo, Giovanni Marfella, Raffaele Sasso, Ferdinando Carlo |
author_facet | Salvatore, Teresa Galiero, Raffaele Caturano, Alfredo Rinaldi, Luca Criscuolo, Livio Di Martino, Anna Albanese, Gaetana Vetrano, Erica Catalini, Christian Sardu, Celestino Docimo, Giovanni Marfella, Raffaele Sasso, Ferdinando Carlo |
author_sort | Salvatore, Teresa |
collection | PubMed |
description | Since early times, being overweight and obesity have been associated with impaired glucose metabolism and type 2 diabetes (T2D). Similarly, a less frequent adult-onset diabetes in low body mass index (BMI) people has been known for many decades. This form is mainly found in developing countries, whereby the largest increase in diabetes incidence is expected in coming years. The number of non-obese patients with T2D is also on the rise among non-white ethnic minorities living in high-income Western countries due to growing migratory flows. A great deal of energy has been spent on understanding the mechanisms that bind obesity to T2D. Conversely, the pathophysiologic features and factors driving the risk of T2D development in non-obese people are still much debated. To reduce the global burden of diabetes, we need to understand why not all obese people develop T2D and not all those with T2D are obese. Moreover, through both an effective prevention and the implementation of an individualized clinical management in all people with diabetes, it is hoped that this will help to reduce this global burden. The purpose of this review is to take stock of current knowledge about the pathophysiology of diabetes not associated to obesity and to highlight which aspects are worthy of future studies. |
format | Online Article Text |
id | pubmed-9820420 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98204202023-01-07 Current Knowledge on the Pathophysiology of Lean/Normal-Weight Type 2 Diabetes Salvatore, Teresa Galiero, Raffaele Caturano, Alfredo Rinaldi, Luca Criscuolo, Livio Di Martino, Anna Albanese, Gaetana Vetrano, Erica Catalini, Christian Sardu, Celestino Docimo, Giovanni Marfella, Raffaele Sasso, Ferdinando Carlo Int J Mol Sci Review Since early times, being overweight and obesity have been associated with impaired glucose metabolism and type 2 diabetes (T2D). Similarly, a less frequent adult-onset diabetes in low body mass index (BMI) people has been known for many decades. This form is mainly found in developing countries, whereby the largest increase in diabetes incidence is expected in coming years. The number of non-obese patients with T2D is also on the rise among non-white ethnic minorities living in high-income Western countries due to growing migratory flows. A great deal of energy has been spent on understanding the mechanisms that bind obesity to T2D. Conversely, the pathophysiologic features and factors driving the risk of T2D development in non-obese people are still much debated. To reduce the global burden of diabetes, we need to understand why not all obese people develop T2D and not all those with T2D are obese. Moreover, through both an effective prevention and the implementation of an individualized clinical management in all people with diabetes, it is hoped that this will help to reduce this global burden. The purpose of this review is to take stock of current knowledge about the pathophysiology of diabetes not associated to obesity and to highlight which aspects are worthy of future studies. MDPI 2022-12-30 /pmc/articles/PMC9820420/ /pubmed/36614099 http://dx.doi.org/10.3390/ijms24010658 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Salvatore, Teresa Galiero, Raffaele Caturano, Alfredo Rinaldi, Luca Criscuolo, Livio Di Martino, Anna Albanese, Gaetana Vetrano, Erica Catalini, Christian Sardu, Celestino Docimo, Giovanni Marfella, Raffaele Sasso, Ferdinando Carlo Current Knowledge on the Pathophysiology of Lean/Normal-Weight Type 2 Diabetes |
title | Current Knowledge on the Pathophysiology of Lean/Normal-Weight Type 2 Diabetes |
title_full | Current Knowledge on the Pathophysiology of Lean/Normal-Weight Type 2 Diabetes |
title_fullStr | Current Knowledge on the Pathophysiology of Lean/Normal-Weight Type 2 Diabetes |
title_full_unstemmed | Current Knowledge on the Pathophysiology of Lean/Normal-Weight Type 2 Diabetes |
title_short | Current Knowledge on the Pathophysiology of Lean/Normal-Weight Type 2 Diabetes |
title_sort | current knowledge on the pathophysiology of lean/normal-weight type 2 diabetes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820420/ https://www.ncbi.nlm.nih.gov/pubmed/36614099 http://dx.doi.org/10.3390/ijms24010658 |
work_keys_str_mv | AT salvatoreteresa currentknowledgeonthepathophysiologyofleannormalweighttype2diabetes AT galieroraffaele currentknowledgeonthepathophysiologyofleannormalweighttype2diabetes AT caturanoalfredo currentknowledgeonthepathophysiologyofleannormalweighttype2diabetes AT rinaldiluca currentknowledgeonthepathophysiologyofleannormalweighttype2diabetes AT criscuololivio currentknowledgeonthepathophysiologyofleannormalweighttype2diabetes AT dimartinoanna currentknowledgeonthepathophysiologyofleannormalweighttype2diabetes AT albanesegaetana currentknowledgeonthepathophysiologyofleannormalweighttype2diabetes AT vetranoerica currentknowledgeonthepathophysiologyofleannormalweighttype2diabetes AT catalinichristian currentknowledgeonthepathophysiologyofleannormalweighttype2diabetes AT sarducelestino currentknowledgeonthepathophysiologyofleannormalweighttype2diabetes AT docimogiovanni currentknowledgeonthepathophysiologyofleannormalweighttype2diabetes AT marfellaraffaele currentknowledgeonthepathophysiologyofleannormalweighttype2diabetes AT sassoferdinandocarlo currentknowledgeonthepathophysiologyofleannormalweighttype2diabetes |