Cargando…

Mediterranean Diet and Parkinson’s Disease

Parkinson’s disease (PD) is an age-related neurodegenerative disorder, diagnosed on the basis of typical motor disturbances, but also characterized by the presence of non-motor symptoms, such as rapid eye movement (REM)-sleep behavior disorders, olfactory impairment, and constipation, which are ofte...

Descripción completa

Detalles Bibliográficos
Autor principal: Bisaglia, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820428/
https://www.ncbi.nlm.nih.gov/pubmed/36613486
http://dx.doi.org/10.3390/ijms24010042
_version_ 1784865463261462528
author Bisaglia, Marco
author_facet Bisaglia, Marco
author_sort Bisaglia, Marco
collection PubMed
description Parkinson’s disease (PD) is an age-related neurodegenerative disorder, diagnosed on the basis of typical motor disturbances, but also characterized by the presence of non-motor symptoms, such as rapid eye movement (REM)-sleep behavior disorders, olfactory impairment, and constipation, which are often prodromal to the onset of the disease. PD is often associated with the presence of oxidative brain injury and chronic neuroinflammation, with infiltration and accumulation of peripheral immune cells that have been found in affected brain regions of PD patients. Recently, the role of the gut-brain axis in the pathogenesis of PD is getting more and more attention, and several pieces of evidence indicate alterations in the gut microbiota of PD-affected patients. Diet exerts a central role in defining the microbiota composition and different dietetic patterns can result in a higher or lower abundance of specific bacteria that, in turn, can affect gut permeability and express anti- or pro-inflammatory metabolites. In the present review, the effects of the Mediterranean diet in modulating both PD onset and its progression will be considered with a special focus on the antioxidant and anti-inflammatory properties of this dietetic regimen as well as on its effects on the microbiota composition.
format Online
Article
Text
id pubmed-9820428
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98204282023-01-07 Mediterranean Diet and Parkinson’s Disease Bisaglia, Marco Int J Mol Sci Review Parkinson’s disease (PD) is an age-related neurodegenerative disorder, diagnosed on the basis of typical motor disturbances, but also characterized by the presence of non-motor symptoms, such as rapid eye movement (REM)-sleep behavior disorders, olfactory impairment, and constipation, which are often prodromal to the onset of the disease. PD is often associated with the presence of oxidative brain injury and chronic neuroinflammation, with infiltration and accumulation of peripheral immune cells that have been found in affected brain regions of PD patients. Recently, the role of the gut-brain axis in the pathogenesis of PD is getting more and more attention, and several pieces of evidence indicate alterations in the gut microbiota of PD-affected patients. Diet exerts a central role in defining the microbiota composition and different dietetic patterns can result in a higher or lower abundance of specific bacteria that, in turn, can affect gut permeability and express anti- or pro-inflammatory metabolites. In the present review, the effects of the Mediterranean diet in modulating both PD onset and its progression will be considered with a special focus on the antioxidant and anti-inflammatory properties of this dietetic regimen as well as on its effects on the microbiota composition. MDPI 2022-12-20 /pmc/articles/PMC9820428/ /pubmed/36613486 http://dx.doi.org/10.3390/ijms24010042 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bisaglia, Marco
Mediterranean Diet and Parkinson’s Disease
title Mediterranean Diet and Parkinson’s Disease
title_full Mediterranean Diet and Parkinson’s Disease
title_fullStr Mediterranean Diet and Parkinson’s Disease
title_full_unstemmed Mediterranean Diet and Parkinson’s Disease
title_short Mediterranean Diet and Parkinson’s Disease
title_sort mediterranean diet and parkinson’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820428/
https://www.ncbi.nlm.nih.gov/pubmed/36613486
http://dx.doi.org/10.3390/ijms24010042
work_keys_str_mv AT bisagliamarco mediterraneandietandparkinsonsdisease