Alpha-Lipoic Acid and Its Enantiomers Prevent Methemoglobin Formation and DNA Damage Induced by Dapsone Hydroxylamine: Molecular Mechanism and Antioxidant Action

Dapsone (DDS) therapy can frequently lead to hematological side effects, such as methemoglobinemia and DNA damage. In this study, we aim to evaluate the protective effect of racemic alpha lipoic acid (ALA) and its enantiomers on methemoglobin induction. The pre- and post-treatment of erythrocytes wi...

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Detalles Bibliográficos
Autores principales: Espíndola, Kaio Murilo Monteiro, Varela, Everton Luiz Pompeu, de Albuquerque, Rosyana de Fátima Vieira, Figueiredo, Rosiane Araújo, dos Santos, Sávio Monteiro, Malcher, Nívea Silva, da S. Seabra, Pamela Suelen, Fonseca, Andréia do Nascimento, de Azevedo Sousa, Karla Marcely, de Oliveira, Susan Beatriz Batista, Carneiro, Agnaldo da Silva, Coleman, Michael D., Monteiro, Marta Chagas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820452/
https://www.ncbi.nlm.nih.gov/pubmed/36613503
http://dx.doi.org/10.3390/ijms24010057

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