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CT and MRI Imaging of Theranostic Bimodal Fe(3)O(4)@Au NanoParticles in Tumor Bearing Mice
Gold-containing nanoparticles are proven to be an effective radiosensitizer in the radiotherapy of tumors. Reliable imaging of nanoparticles in a tumor and surrounding normal tissues is crucial both for diagnostics and for nanoparticle application as radiosensitizers. The Fe(3)O(4) core was introduc...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820463/ https://www.ncbi.nlm.nih.gov/pubmed/36613511 http://dx.doi.org/10.3390/ijms24010070 |
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author | Lipengolts, Alexey A. Finogenova, Yulia A. Skribitsky, Vsevolod A. Shpakova, Kristina E. Anaki, Adi Motiei, Menachem Semkina, Alevtina S. Abakumov, Maxim A. Smirnova, Anna V. Grigorieva, Elena Y. Popovtzer, Rachela |
author_facet | Lipengolts, Alexey A. Finogenova, Yulia A. Skribitsky, Vsevolod A. Shpakova, Kristina E. Anaki, Adi Motiei, Menachem Semkina, Alevtina S. Abakumov, Maxim A. Smirnova, Anna V. Grigorieva, Elena Y. Popovtzer, Rachela |
author_sort | Lipengolts, Alexey A. |
collection | PubMed |
description | Gold-containing nanoparticles are proven to be an effective radiosensitizer in the radiotherapy of tumors. Reliable imaging of nanoparticles in a tumor and surrounding normal tissues is crucial both for diagnostics and for nanoparticle application as radiosensitizers. The Fe(3)O(4) core was introduced into gold nanoparticles to form a core/shell structure suitable for MRI imaging. The aim of this study was to assess the in vivo bimodal CT and MRI enhancement ability of novel core/shell Fe(3)O(4)@Au theranostic nanoparticles. Core/shell Fe(3)O(4)@Au nanoparticles were synthesized and coated with PEG and glucose. C57Bl/6 mice bearing Ca755 mammary adenocarcinoma tumors received intravenous injections of the nanoparticles. CT and MRI were performed at several timepoints between 5 and 102 min, and on day 17 post-injection. Core/shell Fe(3)O(4)@Au nanoparticles provided significant enhancement of the tumor and tumor blood vessels. Nanoparticles also accumulated in the liver and spleen and were retained in these organs for 17 days. Mice did not show any signs of toxicity over the study duration. These results indicate that theranostic bimodal Fe(3)O(4)@Au nanoparticles are non-toxic and serve as effective contrast agents both for CT and MRI diagnostics. These nanoparticles have potential for future biomedical applications in cancer diagnostics and beyond. |
format | Online Article Text |
id | pubmed-9820463 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98204632023-01-07 CT and MRI Imaging of Theranostic Bimodal Fe(3)O(4)@Au NanoParticles in Tumor Bearing Mice Lipengolts, Alexey A. Finogenova, Yulia A. Skribitsky, Vsevolod A. Shpakova, Kristina E. Anaki, Adi Motiei, Menachem Semkina, Alevtina S. Abakumov, Maxim A. Smirnova, Anna V. Grigorieva, Elena Y. Popovtzer, Rachela Int J Mol Sci Article Gold-containing nanoparticles are proven to be an effective radiosensitizer in the radiotherapy of tumors. Reliable imaging of nanoparticles in a tumor and surrounding normal tissues is crucial both for diagnostics and for nanoparticle application as radiosensitizers. The Fe(3)O(4) core was introduced into gold nanoparticles to form a core/shell structure suitable for MRI imaging. The aim of this study was to assess the in vivo bimodal CT and MRI enhancement ability of novel core/shell Fe(3)O(4)@Au theranostic nanoparticles. Core/shell Fe(3)O(4)@Au nanoparticles were synthesized and coated with PEG and glucose. C57Bl/6 mice bearing Ca755 mammary adenocarcinoma tumors received intravenous injections of the nanoparticles. CT and MRI were performed at several timepoints between 5 and 102 min, and on day 17 post-injection. Core/shell Fe(3)O(4)@Au nanoparticles provided significant enhancement of the tumor and tumor blood vessels. Nanoparticles also accumulated in the liver and spleen and were retained in these organs for 17 days. Mice did not show any signs of toxicity over the study duration. These results indicate that theranostic bimodal Fe(3)O(4)@Au nanoparticles are non-toxic and serve as effective contrast agents both for CT and MRI diagnostics. These nanoparticles have potential for future biomedical applications in cancer diagnostics and beyond. MDPI 2022-12-21 /pmc/articles/PMC9820463/ /pubmed/36613511 http://dx.doi.org/10.3390/ijms24010070 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lipengolts, Alexey A. Finogenova, Yulia A. Skribitsky, Vsevolod A. Shpakova, Kristina E. Anaki, Adi Motiei, Menachem Semkina, Alevtina S. Abakumov, Maxim A. Smirnova, Anna V. Grigorieva, Elena Y. Popovtzer, Rachela CT and MRI Imaging of Theranostic Bimodal Fe(3)O(4)@Au NanoParticles in Tumor Bearing Mice |
title | CT and MRI Imaging of Theranostic Bimodal Fe(3)O(4)@Au NanoParticles in Tumor Bearing Mice |
title_full | CT and MRI Imaging of Theranostic Bimodal Fe(3)O(4)@Au NanoParticles in Tumor Bearing Mice |
title_fullStr | CT and MRI Imaging of Theranostic Bimodal Fe(3)O(4)@Au NanoParticles in Tumor Bearing Mice |
title_full_unstemmed | CT and MRI Imaging of Theranostic Bimodal Fe(3)O(4)@Au NanoParticles in Tumor Bearing Mice |
title_short | CT and MRI Imaging of Theranostic Bimodal Fe(3)O(4)@Au NanoParticles in Tumor Bearing Mice |
title_sort | ct and mri imaging of theranostic bimodal fe(3)o(4)@au nanoparticles in tumor bearing mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820463/ https://www.ncbi.nlm.nih.gov/pubmed/36613511 http://dx.doi.org/10.3390/ijms24010070 |
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