Metformin Attenuates Hyperglycaemia-Stimulated Pro-Fibrotic Gene Expression in Adventitial Fibroblasts via Inhibition of Discoidin Domain Receptor 2

Molecular mechanisms underlying the diverse therapeutic effects of anti-diabetic metformin, beyond its anti-hyperglycaemic effects, remain largely unclear. Metformin is reported to reduce the long-term complications of diabetes, including cardiovascular fibrosis and remodelling. Our recent investiga...

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Detalles Bibliográficos
Autores principales: Titus, Allen Sam, Ushakumary, Mereena George, Venugopal, Harikrishnan, Wang, Mingyi, Lakatta, Edward G., Kailasam, Shivakumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820506/
https://www.ncbi.nlm.nih.gov/pubmed/36614028
http://dx.doi.org/10.3390/ijms24010585

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