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The Diagnostic Performance of Ultrasonography in the Evaluation of Extrathyroidal Extension in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis

Extrathyroidal extension (ETE) in patients with papillary thyroid carcinoma (PTC) is an indication of disease progression and can influence treatment aggressiveness. This meta-analysis assesses the diagnostic accuracy of ultrasonography (US) in detecting ETE. A systematic review and meta-analysis we...

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Autores principales: Issa, Peter P., Albuck, Aaron L., Hossam, Eslam, Hussein, Mohammad, Aboueisha, Mohamed, Attia, Abdallah S., Omar, Mahmoud, Abdelrahman, Seif, Naser, Gehad, Clark, Robert D. E., Toraih, Eman, Kandil, Emad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820513/
https://www.ncbi.nlm.nih.gov/pubmed/36613811
http://dx.doi.org/10.3390/ijms24010371
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author Issa, Peter P.
Albuck, Aaron L.
Hossam, Eslam
Hussein, Mohammad
Aboueisha, Mohamed
Attia, Abdallah S.
Omar, Mahmoud
Abdelrahman, Seif
Naser, Gehad
Clark, Robert D. E.
Toraih, Eman
Kandil, Emad
author_facet Issa, Peter P.
Albuck, Aaron L.
Hossam, Eslam
Hussein, Mohammad
Aboueisha, Mohamed
Attia, Abdallah S.
Omar, Mahmoud
Abdelrahman, Seif
Naser, Gehad
Clark, Robert D. E.
Toraih, Eman
Kandil, Emad
author_sort Issa, Peter P.
collection PubMed
description Extrathyroidal extension (ETE) in patients with papillary thyroid carcinoma (PTC) is an indication of disease progression and can influence treatment aggressiveness. This meta-analysis assesses the diagnostic accuracy of ultrasonography (US) in detecting ETE. A systematic review and meta-analysis were performed by searching PubMed, Embase, and Cochrane for studies published up to April 2022. The pooled sensitivity, specificity, and diagnostic odds ratio (DOR) were calculated. The areas under the curve (AUC) for summary receiver operating curves were compared. A total of 11 studies analyzed ETE in 3795 patients with PTC. The sensitivity of ETE detection was 76% (95%CI = 74–78%). The specificity of ETE detection was 51% (95%CI = 49–54%). The DOR of detecting ETE by US was 5.32 (95%CI = 2.54–11.14). The AUC of ETE detection was determined to be 0.6874 ± 0.0841. We report an up-to-date analysis elucidating the diagnostic accuracy of ETE detection by US. Our work suggests the diagnostic accuracy of US in detecting ETE is adequate. Considering the importance of ETE detection on preoperative assessment, ancillary studies such as adjunct imaging studies and genetic testing should be considered.
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spelling pubmed-98205132023-01-07 The Diagnostic Performance of Ultrasonography in the Evaluation of Extrathyroidal Extension in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis Issa, Peter P. Albuck, Aaron L. Hossam, Eslam Hussein, Mohammad Aboueisha, Mohamed Attia, Abdallah S. Omar, Mahmoud Abdelrahman, Seif Naser, Gehad Clark, Robert D. E. Toraih, Eman Kandil, Emad Int J Mol Sci Review Extrathyroidal extension (ETE) in patients with papillary thyroid carcinoma (PTC) is an indication of disease progression and can influence treatment aggressiveness. This meta-analysis assesses the diagnostic accuracy of ultrasonography (US) in detecting ETE. A systematic review and meta-analysis were performed by searching PubMed, Embase, and Cochrane for studies published up to April 2022. The pooled sensitivity, specificity, and diagnostic odds ratio (DOR) were calculated. The areas under the curve (AUC) for summary receiver operating curves were compared. A total of 11 studies analyzed ETE in 3795 patients with PTC. The sensitivity of ETE detection was 76% (95%CI = 74–78%). The specificity of ETE detection was 51% (95%CI = 49–54%). The DOR of detecting ETE by US was 5.32 (95%CI = 2.54–11.14). The AUC of ETE detection was determined to be 0.6874 ± 0.0841. We report an up-to-date analysis elucidating the diagnostic accuracy of ETE detection by US. Our work suggests the diagnostic accuracy of US in detecting ETE is adequate. Considering the importance of ETE detection on preoperative assessment, ancillary studies such as adjunct imaging studies and genetic testing should be considered. MDPI 2022-12-26 /pmc/articles/PMC9820513/ /pubmed/36613811 http://dx.doi.org/10.3390/ijms24010371 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Issa, Peter P.
Albuck, Aaron L.
Hossam, Eslam
Hussein, Mohammad
Aboueisha, Mohamed
Attia, Abdallah S.
Omar, Mahmoud
Abdelrahman, Seif
Naser, Gehad
Clark, Robert D. E.
Toraih, Eman
Kandil, Emad
The Diagnostic Performance of Ultrasonography in the Evaluation of Extrathyroidal Extension in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis
title The Diagnostic Performance of Ultrasonography in the Evaluation of Extrathyroidal Extension in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis
title_full The Diagnostic Performance of Ultrasonography in the Evaluation of Extrathyroidal Extension in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis
title_fullStr The Diagnostic Performance of Ultrasonography in the Evaluation of Extrathyroidal Extension in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis
title_full_unstemmed The Diagnostic Performance of Ultrasonography in the Evaluation of Extrathyroidal Extension in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis
title_short The Diagnostic Performance of Ultrasonography in the Evaluation of Extrathyroidal Extension in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis
title_sort diagnostic performance of ultrasonography in the evaluation of extrathyroidal extension in papillary thyroid carcinoma: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820513/
https://www.ncbi.nlm.nih.gov/pubmed/36613811
http://dx.doi.org/10.3390/ijms24010371
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