Parahydrogen-Induced Hyperpolarization of Unsaturated Phosphoric Acid Derivatives

Parahydrogen-induced nuclear polarization offers a significant increase in the sensitivity of NMR spectroscopy to create new probes for medical diagnostics by magnetic resonance imaging. As precursors of the biocompatible hyperpolarized probes, unsaturated derivatives of phosphoric acid, propargyl a...

Descripción completa

Detalles Bibliográficos
Autores principales: Zlobina, Veronika V., Kiryutin, Alexey S., Nikovskiy, Igor A., Artyushin, Oleg I., Kozinenko, Vitaly P., Peregudov, Alexander S., Yurkovskaya, Alexandra V., Novikov, Valentin V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820518/
https://www.ncbi.nlm.nih.gov/pubmed/36613997
http://dx.doi.org/10.3390/ijms24010557
Descripción
Sumario:Parahydrogen-induced nuclear polarization offers a significant increase in the sensitivity of NMR spectroscopy to create new probes for medical diagnostics by magnetic resonance imaging. As precursors of the biocompatible hyperpolarized probes, unsaturated derivatives of phosphoric acid, propargyl and allyl phosphates, are proposed. The polarization transfer to (1)H and (31)P nuclei of the products of their hydrogenation by parahydrogen under the ALTADENA and PASADENA conditions, and by the PH-ECHO-INEPT+ pulse sequence of NMR spectroscopy, resulted in a very high signal amplification, which is among the largest for parahydrogen-induced nuclear polarization transfer to the (31)P nucleus.

Ejemplares similares