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Microbiome and Metabolomics in Liver Cancer: Scientific Technology
Primary liver cancer is a heterogeneous disease. Liver cancer metabolism includes both the reprogramming of intracellular metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor microenvironment and fluctuations in regular tissue metabolism. Currently, metabolomics an...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820585/ https://www.ncbi.nlm.nih.gov/pubmed/36613980 http://dx.doi.org/10.3390/ijms24010537 |
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author | Ganesan, Raja Yoon, Sang Jun Suk, Ki Tae |
author_facet | Ganesan, Raja Yoon, Sang Jun Suk, Ki Tae |
author_sort | Ganesan, Raja |
collection | PubMed |
description | Primary liver cancer is a heterogeneous disease. Liver cancer metabolism includes both the reprogramming of intracellular metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor microenvironment and fluctuations in regular tissue metabolism. Currently, metabolomics and metabolite profiling in liver cirrhosis, liver cancer, and hepatocellular carcinoma (HCC) have been in the spotlight in terms of cancer diagnosis, monitoring, and therapy. Metabolomics is the global analysis of small molecules, chemicals, and metabolites. Metabolomics technologies can provide critical information about the liver cancer state. Here, we review how liver cirrhosis, liver cancer, and HCC therapies interact with metabolism at the cellular and systemic levels. An overview of liver metabolomics is provided, with a focus on currently available technologies and how they have been used in clinical and translational research. We also list scalable methods, including chemometrics, followed by pathway processing in liver cancer. We conclude that important drivers of metabolomics science and scientific technologies are novel therapeutic tools and liver cancer biomarker analysis. |
format | Online Article Text |
id | pubmed-9820585 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98205852023-01-07 Microbiome and Metabolomics in Liver Cancer: Scientific Technology Ganesan, Raja Yoon, Sang Jun Suk, Ki Tae Int J Mol Sci Review Primary liver cancer is a heterogeneous disease. Liver cancer metabolism includes both the reprogramming of intracellular metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor microenvironment and fluctuations in regular tissue metabolism. Currently, metabolomics and metabolite profiling in liver cirrhosis, liver cancer, and hepatocellular carcinoma (HCC) have been in the spotlight in terms of cancer diagnosis, monitoring, and therapy. Metabolomics is the global analysis of small molecules, chemicals, and metabolites. Metabolomics technologies can provide critical information about the liver cancer state. Here, we review how liver cirrhosis, liver cancer, and HCC therapies interact with metabolism at the cellular and systemic levels. An overview of liver metabolomics is provided, with a focus on currently available technologies and how they have been used in clinical and translational research. We also list scalable methods, including chemometrics, followed by pathway processing in liver cancer. We conclude that important drivers of metabolomics science and scientific technologies are novel therapeutic tools and liver cancer biomarker analysis. MDPI 2022-12-28 /pmc/articles/PMC9820585/ /pubmed/36613980 http://dx.doi.org/10.3390/ijms24010537 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ganesan, Raja Yoon, Sang Jun Suk, Ki Tae Microbiome and Metabolomics in Liver Cancer: Scientific Technology |
title | Microbiome and Metabolomics in Liver Cancer: Scientific Technology |
title_full | Microbiome and Metabolomics in Liver Cancer: Scientific Technology |
title_fullStr | Microbiome and Metabolomics in Liver Cancer: Scientific Technology |
title_full_unstemmed | Microbiome and Metabolomics in Liver Cancer: Scientific Technology |
title_short | Microbiome and Metabolomics in Liver Cancer: Scientific Technology |
title_sort | microbiome and metabolomics in liver cancer: scientific technology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820585/ https://www.ncbi.nlm.nih.gov/pubmed/36613980 http://dx.doi.org/10.3390/ijms24010537 |
work_keys_str_mv | AT ganesanraja microbiomeandmetabolomicsinlivercancerscientifictechnology AT yoonsangjun microbiomeandmetabolomicsinlivercancerscientifictechnology AT sukkitae microbiomeandmetabolomicsinlivercancerscientifictechnology |