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Microbiome and Metabolomics in Liver Cancer: Scientific Technology

Primary liver cancer is a heterogeneous disease. Liver cancer metabolism includes both the reprogramming of intracellular metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor microenvironment and fluctuations in regular tissue metabolism. Currently, metabolomics an...

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Detalles Bibliográficos
Autores principales: Ganesan, Raja, Yoon, Sang Jun, Suk, Ki Tae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820585/
https://www.ncbi.nlm.nih.gov/pubmed/36613980
http://dx.doi.org/10.3390/ijms24010537
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author Ganesan, Raja
Yoon, Sang Jun
Suk, Ki Tae
author_facet Ganesan, Raja
Yoon, Sang Jun
Suk, Ki Tae
author_sort Ganesan, Raja
collection PubMed
description Primary liver cancer is a heterogeneous disease. Liver cancer metabolism includes both the reprogramming of intracellular metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor microenvironment and fluctuations in regular tissue metabolism. Currently, metabolomics and metabolite profiling in liver cirrhosis, liver cancer, and hepatocellular carcinoma (HCC) have been in the spotlight in terms of cancer diagnosis, monitoring, and therapy. Metabolomics is the global analysis of small molecules, chemicals, and metabolites. Metabolomics technologies can provide critical information about the liver cancer state. Here, we review how liver cirrhosis, liver cancer, and HCC therapies interact with metabolism at the cellular and systemic levels. An overview of liver metabolomics is provided, with a focus on currently available technologies and how they have been used in clinical and translational research. We also list scalable methods, including chemometrics, followed by pathway processing in liver cancer. We conclude that important drivers of metabolomics science and scientific technologies are novel therapeutic tools and liver cancer biomarker analysis.
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spelling pubmed-98205852023-01-07 Microbiome and Metabolomics in Liver Cancer: Scientific Technology Ganesan, Raja Yoon, Sang Jun Suk, Ki Tae Int J Mol Sci Review Primary liver cancer is a heterogeneous disease. Liver cancer metabolism includes both the reprogramming of intracellular metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor microenvironment and fluctuations in regular tissue metabolism. Currently, metabolomics and metabolite profiling in liver cirrhosis, liver cancer, and hepatocellular carcinoma (HCC) have been in the spotlight in terms of cancer diagnosis, monitoring, and therapy. Metabolomics is the global analysis of small molecules, chemicals, and metabolites. Metabolomics technologies can provide critical information about the liver cancer state. Here, we review how liver cirrhosis, liver cancer, and HCC therapies interact with metabolism at the cellular and systemic levels. An overview of liver metabolomics is provided, with a focus on currently available technologies and how they have been used in clinical and translational research. We also list scalable methods, including chemometrics, followed by pathway processing in liver cancer. We conclude that important drivers of metabolomics science and scientific technologies are novel therapeutic tools and liver cancer biomarker analysis. MDPI 2022-12-28 /pmc/articles/PMC9820585/ /pubmed/36613980 http://dx.doi.org/10.3390/ijms24010537 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ganesan, Raja
Yoon, Sang Jun
Suk, Ki Tae
Microbiome and Metabolomics in Liver Cancer: Scientific Technology
title Microbiome and Metabolomics in Liver Cancer: Scientific Technology
title_full Microbiome and Metabolomics in Liver Cancer: Scientific Technology
title_fullStr Microbiome and Metabolomics in Liver Cancer: Scientific Technology
title_full_unstemmed Microbiome and Metabolomics in Liver Cancer: Scientific Technology
title_short Microbiome and Metabolomics in Liver Cancer: Scientific Technology
title_sort microbiome and metabolomics in liver cancer: scientific technology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820585/
https://www.ncbi.nlm.nih.gov/pubmed/36613980
http://dx.doi.org/10.3390/ijms24010537
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